+++ /dev/null
-#include "mltaln.h"
-#include "dp.h"
-
-#define MEMSAVE 1
-
-#define DEBUG 1
-#define USE_PENALTY_EX 1
-#define STOREWM 1
-
-
-
-static float singleribosumscore( int n1, int n2, char **s1, char **s2, double *eff1, double *eff2, int p1, int p2 )
-{
- float val;
- int i, j;
- int code1, code2;
-
- val = 0.0;
- for( i=0; i<n1; i++ ) for( j=0; j<n2; j++ )
- {
- code1 = amino_n[(int)s1[i][p1]];
- if( code1 > 3 ) code1 = 36;
- code2 = amino_n[(int)s2[j][p2]];
- if( code2 > 3 ) code2 = 36;
-
-// fprintf( stderr, "'l'%c-%c: %f\n", s1[i][p1], s2[j][p2], (float)ribosumdis[code1][code2] );
-
- val += (float)ribosumdis[code1][code2] * eff1[i] * eff2[j];
- }
- return( val );
-}
-static float pairedribosumscore53( int n1, int n2, char **s1, char **s2, double *eff1, double *eff2, int p1, int p2, int c1, int c2 )
-{
- float val;
- int i, j;
- int code1o, code1u, code2o, code2u, code1, code2;
-
- val = 0.0;
- for( i=0; i<n1; i++ ) for( j=0; j<n2; j++ )
- {
- code1o = amino_n[(int)s1[i][p1]];
- code1u = amino_n[(int)s1[i][c1]];
- if( code1o > 3 ) code1 = code1o = 36;
- else if( code1u > 3 ) code1 = 36;
- else code1 = 4 + code1o * 4 + code1u;
-
- code2o = amino_n[(int)s2[j][p2]];
- code2u = amino_n[(int)s2[j][c2]];
- if( code2o > 3 ) code2 = code1o = 36;
- else if( code2u > 3 ) code2 = 36;
- else code2 = 4 + code2o * 4 + code2u;
-
-
-// fprintf( stderr, "%c%c-%c%c: %f\n", s1[i][p1], s1[i][c1], s2[j][p2], s2[j][c2], (float)ribosumdis[code1][code2] );
-
- if( code1 == 36 || code2 == 36 )
- val += (float)n_dis[code1o][code2o] * eff1[i] * eff2[j];
- else
- val += (float)ribosumdis[code1][code2] * eff1[i] * eff2[j];
- }
- return( val );
-}
-
-static float pairedribosumscore35( int n1, int n2, char **s1, char **s2, double *eff1, double *eff2, int p1, int p2, int c1, int c2 )
-{
- float val;
- int i, j;
- int code1o, code1u, code2o, code2u, code1, code2;
-
- val = 0.0;
- for( i=0; i<n1; i++ ) for( j=0; j<n2; j++ )
- {
- code1o = amino_n[(int)s1[i][p1]];
- code1u = amino_n[(int)s1[i][c1]];
- if( code1o > 3 ) code1 = code1o = 36;
- else if( code1u > 3 ) code1 = 36;
- else code1 = 4 + code1u * 4 + code1o;
-
- code2o = amino_n[(int)s2[j][p2]];
- code2u = amino_n[(int)s2[j][c2]];
- if( code2o > 3 ) code2 = code1o = 36;
- else if( code2u > 3 ) code2 = 36;
- else code2 = 4 + code2u * 4 + code2o;
-
-
-// fprintf( stderr, "%c%c-%c%c: %f\n", s1[i][p1], s1[i][c1], s2[j][p2], s2[j][c2], (float)ribosumdis[code1][code2] );
-
- if( code1 == 36 || code2 == 36 )
- val += (float)n_dis[code1o][code2o] * eff1[i] * eff2[j];
- else
- val += (float)ribosumdis[code1][code2] * eff1[i] * eff2[j];
- }
- return( val );
-}
-
-
-static void mccaskillextract( char **seq, char **nogap, int nseq, RNApair **pairprob, RNApair ***single, int **sgapmap, double *eff )
-{
- int lgth;
- int nogaplgth;
- int i, j;
- int left, right, adpos;
- float prob;
- static TLS int *pairnum;
- RNApair *pt, *pt2;
-
- lgth = strlen( seq[0] );
- pairnum = calloc( lgth, sizeof( int ) );
- for( i=0; i<lgth; i++ ) pairnum[i] = 0;
-
- for( i=0; i<nseq; i++ )
- {
- nogaplgth = strlen( nogap[i] );
- for( j=0; j<nogaplgth; j++ ) for( pt=single[i][j]; pt->bestpos!=-1; pt++ )
- {
- left = sgapmap[i][j];
- right = sgapmap[i][pt->bestpos];
- prob = pt->bestscore;
-
-
- for( pt2=pairprob[left]; pt2->bestpos!=-1; pt2++ )
- if( pt2->bestpos == right ) break;
-
-// fprintf( stderr, "i,j=%d,%d, left=%d, right=%d, pt=%d, pt2->bestpos = %d\n", i, j, left, right, pt-single[i][j], pt2->bestpos );
- if( pt2->bestpos == -1 )
- {
- pairprob[left] = (RNApair *)realloc( pairprob[left], (pairnum[left]+2) * sizeof( RNApair ) );
- adpos = pairnum[left];
- pairnum[left]++;
- pairprob[left][adpos].bestscore = 0.0;
- pairprob[left][adpos].bestpos = right;
- pairprob[left][adpos+1].bestscore = -1.0;
- pairprob[left][adpos+1].bestpos = -1;
- pt2 = pairprob[left]+adpos;
- }
- else
- adpos = pt2-pairprob[left];
-
- pt2->bestscore += prob * eff[i];
-
- if( pt2->bestpos != right )
- {
- fprintf( stderr, "okashii!\n" );
- exit( 1 );
- }
-// fprintf( stderr, "adding %d-%d, %f\n", left, right, prob );
-// fprintf( stderr, "pairprob[0][0].bestpos=%d\n", pairprob[0][0].bestpos );
-// fprintf( stderr, "pairprob[0][0].bestscore=%f\n", pairprob[0][0].bestscore );
- }
- }
-
-// fprintf( stderr, "before taikakuka\n" );
- for( i=0; i<lgth; i++ ) for( j=0; j<pairnum[i]; j++ )
- {
- if( pairprob[i][j].bestpos > -1 )
- {
-// pairprob[i][j].bestscore /= (float)nseq;
-// fprintf( stderr, "pair of %d = %d (%f) %c:%c\n", i, pairprob[i][j].bestpos, pairprob[i][j].bestscore, seq[0][i], seq[0][pairprob[i][j].bestpos] );
- }
- }
-
-#if 0
- for( i=0; i<lgth; i++ ) for( j=0; j<pairnum[i]; j++ )
- {
- right=pairprob[i][j].bestpos;
- if( right < i ) continue;
- fprintf( stderr, "no%d-%d, adding %d -> %d\n", i, j, right, i );
- pairprob[right] = (RNApair *)realloc( pairprob[right], (pairnum[right]+2) * sizeof( RNApair ) );
- pairprob[right][pairnum[right]].bestscore = pairprob[i][j].bestscore;
- pairprob[right][pairnum[right]].bestpos = i;
- pairnum[right]++;
- pairprob[right][pairnum[right]].bestscore = -1.0;
- pairprob[right][pairnum[right]].bestpos = -1;
- }
-#endif
-
- free( pairnum );
-
-}
-
-
-void rnaalifoldcall( char **seq, int nseq, RNApair **pairprob )
-{
- int lgth;
- int i;
- static TLS int *order = NULL;
- static TLS char **name = NULL;
- char gett[1000];
- FILE *fp;
- int left, right, dumm;
- float prob;
- static TLS int pid;
- static TLS char fnamein[100];
- static TLS char cmd[1000];
- static TLS int *pairnum;
-
- lgth = strlen( seq[0] );
- if( order == NULL )
- {
- pid = (int)getpid();
- sprintf( fnamein, "/tmp/_rnaalifoldin.%d", pid );
- order = AllocateIntVec( njob );
- name = AllocateCharMtx( njob, 10 );
- for( i=0; i<njob; i++ )
- {
- order[i] = i;
- sprintf( name[i], "seq%d", i );
- }
- }
- pairnum = calloc( lgth, sizeof( int ) );
- for( i=0; i<lgth; i++ ) pairnum[i] = 0;
-
- fp = fopen( fnamein, "w" );
- if( !fp )
- {
- fprintf( stderr, "Cannot open /tmp/_rnaalifoldin\n" );
- exit( 1 );
- }
- clustalout_pointer( fp, nseq, lgth, seq, name, NULL, NULL, order, 15 );
- fclose( fp );
-
- sprintf( cmd, "RNAalifold -p %s", fnamein );
- system( cmd );
-
- fp = fopen( "alifold.out", "r" );
- if( !fp )
- {
- fprintf( stderr, "Cannot open /tmp/_rnaalifoldin\n" );
- exit( 1 );
- }
-
-#if 0
- for( i=0; i<lgth; i++ ) // atode kesu
- {
- pairprob[i] = (RNApair *)realloc( pairprob[i], (2) * sizeof( RNApair ) ); // atode kesu
- pairprob[i][1].bestscore = -1.0;
- pairprob[i][1].bestpos = -1;
- }
-#endif
-
- while( 1 )
- {
- fgets( gett, 999, fp );
- if( gett[0] == '(' ) break;
- if( gett[0] == '{' ) break;
- if( gett[0] == '.' ) break;
- if( gett[0] == ',' ) break;
- if( gett[0] != ' ' ) continue;
-
- sscanf( gett, "%d %d %d %f", &left, &right, &dumm, &prob );
- left--;
- right--;
-
-
-#if 0
- if( prob > 50.0 && prob > pairprob[left][0].bestscore )
- {
- pairprob[left][0].bestscore = prob;
- pairprob[left][0].bestpos = right;
-#else
- if( prob > 0.0 )
- {
- pairprob[left] = (RNApair *)realloc( pairprob[left], (pairnum[left]+2) * sizeof( RNApair ) );
- pairprob[left][pairnum[left]].bestscore = prob / 100.0;
- pairprob[left][pairnum[left]].bestpos = right;
- pairnum[left]++;
- pairprob[left][pairnum[left]].bestscore = -1.0;
- pairprob[left][pairnum[left]].bestpos = -1;
- fprintf( stderr, "%d-%d, %f\n", left, right, prob );
-
- pairprob[right] = (RNApair *)realloc( pairprob[right], (pairnum[right]+2) * sizeof( RNApair ) );
- pairprob[right][pairnum[right]].bestscore = prob / 100.0;
- pairprob[right][pairnum[right]].bestpos = left;
- pairnum[right]++;
- pairprob[right][pairnum[right]].bestscore = -1.0;
- pairprob[right][pairnum[right]].bestpos = -1;
- fprintf( stderr, "%d-%d, %f\n", left, right, prob );
-#endif
- }
- }
- fclose( fp );
- sprintf( cmd, "rm -f %s", fnamein );
- system( cmd );
-
- for( i=0; i<lgth; i++ )
- {
- if( (right=pairprob[i][0].bestpos) > -1 )
- {
- pairprob[right][0].bestpos = i;
- pairprob[right][0].bestscore = pairprob[i][0].bestscore;
- }
- }
-
-#if 0
- for( i=0; i<lgth; i++ ) // atode kesu
- if( pairprob[i][0].bestscore > -1 ) pairprob[i][0].bestscore = 1.0; // atode kesu
-#endif
-
-// fprintf( stderr, "after taikakuka in rnaalifoldcall\n" );
-// for( i=0; i<lgth; i++ )
-// {
-// fprintf( stderr, "pair of %d = %d (%f) %c:%c\n", i, pairprob[i][0].bestpos, pairprob[i][0].bestscore, seq[0][i], seq[0][pairprob[i][0].bestpos] );
-// }
-
- free( pairnum );
-}
-
-
-static void utot( int n, int l, char **s )
-{
- int i, j;
- for( i=0; i<l; i++ )
- {
- for( j=0; j<n; j++ )
- {
- if ( s[j][i] == 'a' ) s[j][i] = 'a';
- else if( s[j][i] == 't' ) s[j][i] = 't';
- else if( s[j][i] == 'u' ) s[j][i] = 't';
- else if( s[j][i] == 'g' ) s[j][i] = 'g';
- else if( s[j][i] == 'c' ) s[j][i] = 'c';
- else if( s[j][i] == '-' ) s[j][i] = '-';
- else s[j][i] = 'n';
- }
- }
-}
-
-
-void foldrna( int nseq1, int nseq2, char **seq1, char **seq2, double *eff1, double *eff2, RNApair ***grouprna1, RNApair ***grouprna2, float **impmtx, int *gapmap1, int *gapmap2, RNApair *additionalpair )
-{
- int i, j;
-// int ui, uj;
-// int uiup, ujup;
- int uido, ujdo;
- static TLS char **useq1, **useq2;
- static TLS char **oseq1, **oseq2, **oseq1r, **oseq2r, *odir1, *odir2;
- static TLS RNApair **pairprob1, **pairprob2;
- static TLS RNApair *pairpt1, *pairpt2;
- int lgth1 = strlen( seq1[0] );
- int lgth2 = strlen( seq2[0] );
- static TLS float **impmtx2;
- static TLS float **map;
-// double lenfac;
- float prob;
- int **sgapmap1, **sgapmap2;
- char *nogapdum;
- float **tbppmtx;
-
-
-// fprintf( stderr, "nseq1=%d, lgth1=%d\n", nseq1, lgth1 );
- useq1 = AllocateCharMtx( nseq1, lgth1+10 );
- useq2 = AllocateCharMtx( nseq2, lgth2+10 );
- oseq1 = AllocateCharMtx( nseq1, lgth1+10 );
- oseq2 = AllocateCharMtx( nseq2, lgth2+10 );
- oseq1r = AllocateCharMtx( nseq1, lgth1+10 );
- oseq2r = AllocateCharMtx( nseq2, lgth2+10 );
- odir1 = AllocateCharVec( lgth1+10 );
- odir2 = AllocateCharVec( lgth2+10 );
- sgapmap1 = AllocateIntMtx( nseq1, lgth1+1 );
- sgapmap2 = AllocateIntMtx( nseq2, lgth2+1 );
- nogapdum = AllocateCharVec( MAX( lgth1, lgth2 ) );
- pairprob1 = (RNApair **)calloc( lgth1, sizeof( RNApair *) );
- pairprob2 = (RNApair **)calloc( lgth2, sizeof( RNApair *) );
- map = AllocateFloatMtx( lgth1, lgth2 );
- impmtx2 = AllocateFloatMtx( lgth1, lgth2 );
- tbppmtx = AllocateFloatMtx( lgth1, lgth2 );
-
- for( i=0; i<nseq1; i++ ) strcpy( useq1[i], seq1[i] );
- for( i=0; i<nseq2; i++ ) strcpy( useq2[i], seq2[i] );
- for( i=0; i<nseq1; i++ ) strcpy( oseq1[i], seq1[i] );
- for( i=0; i<nseq2; i++ ) strcpy( oseq2[i], seq2[i] );
-
- for( i=0; i<nseq1; i++ ) commongappick_record( 1, useq1+i, sgapmap1[i] );
- for( i=0; i<nseq2; i++ ) commongappick_record( 1, useq2+i, sgapmap2[i] );
-
- for( i=0; i<lgth1; i++ )
- {
- pairprob1[i] = (RNApair *)calloc( 1, sizeof( RNApair ) );
- pairprob1[i][0].bestpos = -1;
- pairprob1[i][0].bestscore = -1;
- }
- for( i=0; i<lgth2; i++ )
- {
- pairprob2[i] = (RNApair *)calloc( 1, sizeof( RNApair ) );
- pairprob2[i][0].bestpos = -1;
- pairprob2[i][0].bestscore = -1;
- }
-
- utot( nseq1, lgth1, oseq1 );
- utot( nseq2, lgth2, oseq2 );
-
-// fprintf( stderr, "folding group1\n" );
-// rnalocal( oseq1, useq1, eff1, eff1, nseq1, nseq1, lgth1+10, pair1 );
-
-/* base-pairing probability of group 1 */
- if( rnaprediction == 'r' )
- rnaalifoldcall( oseq1, nseq1, pairprob1 );
- else
- mccaskillextract( oseq1, useq1, nseq1, pairprob1, grouprna1, sgapmap1, eff1 );
-
-
-// fprintf( stderr, "folding group2\n" );
-// rnalocal( oseq2, useq2, eff2, eff2, nseq2, nseq2, lgth2+10, pair2 );
-
-/* base-pairing probability of group 2 */
- if( rnaprediction == 'r' )
- rnaalifoldcall( oseq2, nseq2, pairprob2 );
- else
- mccaskillextract( oseq2, useq2, nseq2, pairprob2, grouprna2, sgapmap2, eff2 );
-
-
-
-#if 0
- makerseq( oseq1, oseq1r, odir1, pairprob1, nseq1, lgth1 );
- makerseq( oseq2, oseq2r, odir2, pairprob2, nseq2, lgth2 );
-
- fprintf( stderr, "%s\n", odir2 );
-
- for( i=0; i<nseq1; i++ )
- {
- fprintf( stdout, ">ori\n%s\n", oseq1[0] );
- fprintf( stdout, ">rev\n%s\n", oseq1r[0] );
- }
-#endif
-
-/* similarity score */
- Lalignmm_hmout( oseq1, oseq2, eff1, eff2, nseq1, nseq2, 10000, NULL, NULL, NULL, NULL, map );
-
- if( 1 )
- {
- if( RNAscoremtx == 'n' )
- {
- for( i=0; i<lgth1; i++ ) for( j=0; j<lgth2; j++ )
- {
-// impmtx2[i][j] = osoiaveragescore( nseq1, nseq2, oseq1, oseq2, eff1, eff2, i, j ) * consweight_multi;
- impmtx2[i][j] = 0.0;
- }
- }
- else if( RNAscoremtx == 'r' )
- {
- for( i=0; i<lgth1; i++ ) for( j=0; j<lgth2; j++ )
- {
- tbppmtx[i][j] = 1.0;
- impmtx2[i][j] = 0.0;
- }
- for( i=0; i<lgth1; i++ ) for( pairpt1=pairprob1[i]; pairpt1->bestpos!=-1; pairpt1++ )
- {
- for( j=0; j<lgth2; j++ ) for( pairpt2=pairprob2[j]; pairpt2->bestpos!=-1; pairpt2++ )
- {
- uido = pairpt1->bestpos;
- ujdo = pairpt2->bestpos;
- prob = pairpt1->bestscore * pairpt2->bestscore;
- if( uido > -1 && ujdo > -1 )
- {
- if( uido > i && j > ujdo )
- {
- impmtx2[i][j] += prob * pairedribosumscore53( nseq1, nseq2, oseq1, oseq2, eff1, eff2, i, j, uido, ujdo ) * consweight_multi;
- tbppmtx[i][j] -= prob;
- }
- else if( i < uido && j < ujdo )
- {
- impmtx2[i][j] += prob * pairedribosumscore35( nseq1, nseq2, oseq1, oseq2, eff1, eff2, i, j, uido, ujdo ) * consweight_multi;
- tbppmtx[i][j] -= prob;
- }
- }
- }
- }
-
-
- for( i=0; i<lgth1; i++ )
- {
- for( j=0; j<lgth2; j++ )
- {
- impmtx2[i][j] += tbppmtx[i][j] * singleribosumscore( nseq1, nseq2, oseq1, oseq2, eff1, eff2, i, j ) * consweight_multi;
- }
- }
- }
-
-
-/* four-way consistency */
-
- for( i=0; i<lgth1; i++ ) for( pairpt1=pairprob1[i]; pairpt1->bestpos!=-1; pairpt1++ )
- {
-
-// if( pairprob1[i] == NULL ) continue;
-
- for( j=0; j<lgth2; j++ ) for( pairpt2=pairprob2[j]; pairpt2->bestpos!=-1; pairpt2++ )
- {
-// fprintf( stderr, "i=%d, j=%d, pn1=%d, pn2=%d\n", i, j, pairpt1-pairprob1[i], pairpt2-pairprob2[j] );
-// if( pairprob2[j] == NULL ) continue;
-
- uido = pairpt1->bestpos;
- ujdo = pairpt2->bestpos;
- prob = pairpt1->bestscore * pairpt2->bestscore;
-// prob = 1.0;
-// fprintf( stderr, "i=%d->uido=%d, j=%d->ujdo=%d\n", i, uido, j, ujdo );
-
-// fprintf( stderr, "impmtx2[%d][%d] = %f\n", i, j, impmtx2[i][j] );
-
-// if( i < uido && j > ujdo ) continue;
-// if( i > uido && j < ujdo ) continue;
-
-
-// posdistj = abs( ujdo-j );
-
-// if( uido > -1 && ujdo > -1 )
- if( uido > -1 && ujdo > -1 && ( ( i > uido && j > ujdo ) || ( i < uido && j < ujdo ) ) )
- {
- {
- impmtx2[i][j] += MAX( 0, map[uido][ujdo] ) * consweight_rna * 600 * prob; // osoi
- }
- }
-
- }
- }
- for( i=0; i<lgth1; i++ ) for( j=0; j<lgth2; j++ )
- {
- impmtx[i][j] += impmtx2[i][j];
-// fprintf( stderr, "fastathreshold=%f, consweight_multi=%f, consweight_rna=%f\n", fastathreshold, consweight_multi, consweight_rna );
-// impmtx[i][j] *= 0.5;
- }
-
-// impmtx[0][0] += 10000.0;
-// impmtx[lgth1-1][lgth2-1] += 10000.0;
-
-
-
-#if 0
- fprintf( stdout, "#impmtx2 = \n" );
- for( i=0; i<lgth1; i++ )
- {
- for( j=0; j<lgth2; j++ )
- {
- fprintf( stdout, "%d %d %f\n", i, j, impmtx2[i][j] );
- }
- fprintf( stdout, "\n" );
- }
- exit( 1 );
-#endif
- }
-
- FreeCharMtx( useq1 );
- FreeCharMtx( useq2 );
- FreeCharMtx( oseq1 );
- FreeCharMtx( oseq2 );
- FreeCharMtx( oseq1r );
- FreeCharMtx( oseq2r );
- free( odir1 );
- free( odir2 );
- FreeFloatMtx( impmtx2 );
- FreeFloatMtx( map );
- FreeIntMtx( sgapmap1 );
- FreeIntMtx( sgapmap2 );
- FreeFloatMtx( tbppmtx );
-
- for( i=0; i<lgth1; i++ ) free( pairprob1[i] );
- for( i=0; i<lgth2; i++ ) free( pairprob2[i] );
- free( pairprob1 );
- free( pairprob2 );
-}
-