JAL-1645 Version-Rel Version 2.9 Year-Rel 2015 Licensing glob
[jalview.git] / src / jalview / gui / SequenceFetcher.java
index 2e2456b..9f92c42 100755 (executable)
-/*\r
- * Jalview - A Sequence Alignment Editor and Viewer\r
- * Copyright (C) 2005 AM Waterhouse, J Procter, G Barton, M Clamp, S Searle\r
- *\r
- * This program is free software; you can redistribute it and/or\r
- * modify it under the terms of the GNU General Public License\r
- * as published by the Free Software Foundation; either version 2\r
- * of the License, or (at your option) any later version.\r
- *\r
- * This program is distributed in the hope that it will be useful,\r
- * but WITHOUT ANY WARRANTY; without even the implied warranty of\r
- * MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the\r
- * GNU General Public License for more details.\r
- *\r
- * You should have received a copy of the GNU General Public License\r
- * along with this program; if not, write to the Free Software\r
- * Foundation, Inc., 51 Franklin Street, Fifth Floor, Boston, MA  02110-1301, USA\r
- */\r
-package jalview.gui;\r
-\r
-import javax.swing.*;\r
-import java.awt.*;\r
-import java.awt.event.*;\r
-import jalview.io.EBIFetchClient;\r
-import MCview.*;\r
-import jalview.datamodel.*;\r
-import jalview.analysis.AlignSeq;\r
-import java.io.File;\r
-import jalview.io.*;\r
-import java.util.*;\r
-\r
-public class SequenceFetcher\r
-    extends JPanel implements Runnable\r
-{\r
-  JInternalFrame frame;\r
-  AlignFrame alignFrame;\r
-  StringBuffer result;\r
-  final String noDbSelected = "-- Select Database --";\r
-  public SequenceFetcher(AlignFrame af)\r
-  {\r
-    alignFrame = af;\r
-    database.addItem(noDbSelected);\r
-    database.addItem("Uniprot");\r
-    database.addItem("EMBL");\r
-    database.addItem("EMBLCDS");\r
-    database.addItem("PDB");\r
-    database.addItem("PFAM");\r
-\r
-    try\r
-    {\r
-      jbInit();\r
-    }\r
-    catch (Exception ex)\r
-    {\r
-      ex.printStackTrace();\r
-    }\r
-\r
-    frame = new JInternalFrame();\r
-    frame.setContentPane(this);\r
-    if (System.getProperty("os.name").startsWith("Mac"))\r
-      Desktop.addInternalFrame(frame, getFrameTitle(), 400, 140);\r
-    else\r
-      Desktop.addInternalFrame(frame, getFrameTitle(), 400, 125);\r
-  }\r
-\r
-  private String getFrameTitle()\r
-  {\r
-    return ( (alignFrame == null) ? "New " : "Additional ") + "Sequence Fetcher";\r
-  }\r
-\r
-  private void jbInit()\r
-      throws Exception\r
-  {\r
-    this.setLayout(gridBagLayout1);\r
-\r
-    database.setFont(new java.awt.Font("Verdana", Font.PLAIN, 11));\r
-    database.setMinimumSize(new Dimension(160, 21));\r
-    database.setPreferredSize(new Dimension(160, 21));\r
-    jLabel1.setFont(new java.awt.Font("Verdana", Font.ITALIC, 11));\r
-    jLabel1.setText(\r
-        "Separate multiple accession ids with semi colon \";\"");\r
-    ok.setText("OK");\r
-    ok.addActionListener(new ActionListener()\r
-    {\r
-      public void actionPerformed(ActionEvent e)\r
-      {\r
-        ok_actionPerformed(e);\r
-      }\r
-    });\r
-    close.setText("Close");\r
-    close.addActionListener(new ActionListener()\r
-    {\r
-      public void actionPerformed(ActionEvent e)\r
-      {\r
-        close_actionPerformed(e);\r
-      }\r
-    });\r
-    textfield.setFont(new java.awt.Font("Verdana", Font.PLAIN, 11));\r
-    textfield.addActionListener(new ActionListener()\r
-    {\r
-      public void actionPerformed(ActionEvent e)\r
-      {\r
-        ok_actionPerformed(e);\r
-      }\r
-    });\r
-    jPanel1.add(ok);\r
-    jPanel1.add(close);\r
-    this.add(jLabel1, new GridBagConstraints(0, 0, 2, 1, 0.0, 0.0\r
-                                             , GridBagConstraints.WEST,\r
-                                             GridBagConstraints.NONE,\r
-                                             new Insets(7, 4, 0, 6), 77, 6));\r
-    this.add(jPanel1, new GridBagConstraints(0, 2, 2, 1, 1.0, 1.0\r
-                                             , GridBagConstraints.WEST,\r
-                                             GridBagConstraints.BOTH,\r
-                                             new Insets(7, -2, 7, 12), 241, -2));\r
-    this.add(database, new GridBagConstraints(0, 1, 1, 1, 1.0, 0.0\r
-                                              , GridBagConstraints.WEST,\r
-                                              GridBagConstraints.NONE,\r
-                                              new Insets(0, 4, 0, 0), 1, 0));\r
-    this.add(textfield, new GridBagConstraints(1, 1, 1, 1, 1.0, 0.0\r
-                                               , GridBagConstraints.CENTER,\r
-                                               GridBagConstraints.HORIZONTAL,\r
-                                               new Insets(0, 0, 0, 6), 200, 1));\r
-  }\r
-\r
-  JComboBox database = new JComboBox();\r
-  JLabel jLabel1 = new JLabel();\r
-  JButton ok = new JButton();\r
-  JButton close = new JButton();\r
-  JPanel jPanel1 = new JPanel();\r
-  JTextField textfield = new JTextField();\r
-  GridBagLayout gridBagLayout1 = new GridBagLayout();\r
-  public void close_actionPerformed(ActionEvent e)\r
-  {\r
-    try\r
-    {\r
-      frame.setClosed(true);\r
-    }\r
-    catch (Exception ex)\r
-    {}\r
-  }\r
-\r
-  public void ok_actionPerformed(ActionEvent e)\r
-  {\r
-    database.setEnabled(false);\r
-    textfield.setEnabled(false);\r
-    ok.setEnabled(false);\r
-    close.setEnabled(false);\r
-\r
-    Thread worker = new Thread(this);\r
-    worker.start();\r
-  }\r
-\r
-  private void resetDialog()\r
-  {\r
-    database.setEnabled(true);\r
-    textfield.setEnabled(true);\r
-    ok.setEnabled(true);\r
-    close.setEnabled(true);\r
-  }\r
-\r
-  public void run()\r
-  {\r
-    String error = "";\r
-    if (database.getSelectedItem().equals(noDbSelected))\r
-      error += "Please select the source database\n";\r
-    com.stevesoft.pat.Regex empty = new com.stevesoft.pat.Regex("\\s+", "");\r
-    textfield.setText(empty.replaceAll(textfield.getText()));\r
-    if (textfield.getText().length() == 0)\r
-      error += "Please enter a (semi-colon separated list of) database id(s)";\r
-    if (error.length() > 0)\r
-    {\r
-      showErrorMessage(error);\r
-      resetDialog();\r
-      return;\r
-    }\r
-\r
-    result = new StringBuffer();\r
-    if (database.getSelectedItem().equals("Uniprot"))\r
-    {\r
-      getUniprotFile(textfield.getText());\r
-    }\r
-    else if (database.getSelectedItem().equals("EMBL")\r
-             || database.getSelectedItem().equals("EMBLCDS"))\r
-    {\r
-      EBIFetchClient dbFetch = new EBIFetchClient();\r
-      String[] reply = dbFetch.fetchData(\r
-          database.getSelectedItem().toString().toLowerCase(\r
-          ) + ":" + textfield.getText(),\r
-          "fasta", "raw");\r
-\r
-      if(reply!=null)\r
-      {\r
-        for (int i = 0; i < reply.length; i++)\r
-          result.append(reply[i] + "\n");\r
-\r
-        parseResult(result.toString(), null);\r
-      }\r
-    }\r
-    else if (database.getSelectedItem().equals("PDB"))\r
-    {\r
-      StringTokenizer qset = new StringTokenizer(textfield.getText(), ";");\r
-      String query;\r
-      while (qset.hasMoreTokens() && ((query = qset.nextToken())!=null))\r
-      {\r
-        StringBuffer respart = getPDBFile(query.toUpperCase());\r
-        if(respart!=null)\r
-          result.append(respart);\r
-      }\r
-\r
-\r
-      if (result.length()>0)\r
-        parseResult(result.toString(), null);\r
-    }\r
-    else if( database.getSelectedItem().equals("PFAM"))\r
-    {\r
-      try{\r
-        result.append(new FastaFile(\r
-           "http://www.sanger.ac.uk/cgi-bin/Pfam/getalignment.pl?format=fal&acc="\r
-           +  textfield.getText().toUpperCase(), "URL").print()\r
-           );\r
-\r
-         if(result.length()>0)\r
-           parseResult( result.toString(), textfield.getText().toUpperCase() );\r
-\r
-      }catch(java.io.IOException ex)\r
-      {   result = null;    }\r
-    }\r
-\r
-    if (result == null || result.length() == 0)\r
-      showErrorMessage("Error retrieving " + textfield.getText()\r
-                       + " from " + database.getSelectedItem());\r
-\r
-    resetDialog();\r
-    return;\r
-  }\r
-\r
-  void getUniprotFile(String id)\r
-  {\r
-    EBIFetchClient ebi = new EBIFetchClient();\r
-    File file = ebi.fetchDataAsFile("uniprot:" + id, "xml", null);\r
-    SequenceFeatureFetcher sff = new SequenceFeatureFetcher();\r
-    Vector entries = sff.getUniprotEntries(file);\r
-\r
-    if (entries != null)\r
-    {\r
-      //First, make the new sequences\r
-      Enumeration en = entries.elements();\r
-      while (en.hasMoreElements())\r
-      {\r
-        UniprotEntry entry = (UniprotEntry) en.nextElement();\r
-        StringBuffer name = new StringBuffer(">Uniprot/Swiss-Prot");\r
-        Enumeration en2 = entry.getAccession().elements();\r
-        while (en2.hasMoreElements())\r
-        {\r
-          name.append("|");\r
-          name.append(en2.nextElement());\r
-        }\r
-        en2 = entry.getName().elements();\r
-        while (en2.hasMoreElements())\r
-        {\r
-          name.append("|");\r
-          name.append(en2.nextElement());\r
-        }\r
-\r
-        if (entry.getProteinName() != null)\r
-          name.append(" " + entry.getProteinName().elementAt(0));\r
-\r
-        result.append(name + "\n" + entry.getUniprotSequence().getContent() +\r
-                      "\n");\r
-\r
-      }\r
-\r
-      //Then read in the features and apply them to the dataset\r
-      SequenceI[] sequence = parseResult(result.toString(), null);\r
-      for (int i = 0; i < entries.size(); i++)\r
-      {\r
-        UniprotEntry entry = (UniprotEntry) entries.elementAt(i);\r
-        Enumeration e = entry.getDbReference().elements();\r
-        Vector onlyPdbEntries = new Vector();\r
-        while (e.hasMoreElements())\r
-        {\r
-          PDBEntry pdb = (PDBEntry) e.nextElement();\r
-          if (!pdb.getType().equals("PDB"))\r
-            continue;\r
-\r
-          onlyPdbEntries.addElement(pdb);\r
-        }\r
-\r
-        sequence[i].getDatasetSequence().setPDBId(onlyPdbEntries);\r
-        e = entry.getFeature().elements();\r
-        while(e.hasMoreElements())\r
-        {\r
-          sequence[i].getDatasetSequence().addSequenceFeature((SequenceFeature)e.nextElement());\r
-        }\r
-      }\r
-    }\r
-  }\r
-\r
-  StringBuffer getPDBFile(String id)\r
-  {\r
-    StringBuffer result = new StringBuffer();\r
-    String chain = null;\r
-    if (id.indexOf(":") > -1)\r
-    {\r
-      chain = id.substring(id.indexOf(":") + 1);\r
-      id = id.substring(0, id.indexOf(":"));\r
-    }\r
-\r
-    EBIFetchClient ebi = new EBIFetchClient();\r
-    String[] reply = ebi.fetchData("pdb:" + id, "pdb", "raw");\r
-    if (reply == null)\r
-      return null;\r
-    try\r
-    {\r
-      PDBfile pdbfile = new PDBfile(reply);\r
-      for (int i = 0; i < pdbfile.chains.size(); i++)\r
-      {\r
-        if (chain == null ||\r
-            ( (PDBChain) pdbfile.chains.elementAt(i)).id.\r
-            toUpperCase().equals(chain))\r
-          result.append("\n>PDB|" + id + "|" +\r
-                        ( (PDBChain) pdbfile.chains.elementAt(i)).sequence.\r
-                        getName() +\r
-                        "\n"\r
-                        +\r
-                        ( (PDBChain) pdbfile.chains.elementAt(i)).sequence.\r
-                        getSequence());\r
-      }\r
-    }\r
-    catch (Exception ex) // Problem parsing PDB file\r
-    {\r
-      jalview.bin.Cache.log.warn("Exception when retrieving " +\r
-                                 textfield.getText() + " from " +\r
-                                 database.getSelectedItem(), ex);\r
-      return null;\r
-    }\r
-\r
-    return result;\r
-  }\r
-\r
-  SequenceI[] parseResult(String result, String title)\r
-  {\r
-    String format = new IdentifyFile().Identify(result, "Paste");\r
-    SequenceI[] sequences = null;\r
-\r
-    if (FormatAdapter.formats.contains(format))\r
-    {\r
-      sequences = null;\r
-      try{ sequences = new FormatAdapter().readFile(result.toString(), "Paste",\r
-                                               format);}\r
-      catch(Exception ex){}\r
-\r
-      if (sequences != null && sequences.length > 0)\r
-      {\r
-        if (alignFrame == null)\r
-        {\r
-          AlignFrame af = new AlignFrame(new Alignment(sequences));\r
-          af.currentFileFormat = format;\r
-          if(title==null)\r
-            title = "Retrieved from " + database.getSelectedItem();\r
-          Desktop.addInternalFrame(af,\r
-                                   title,\r
-                                   AlignFrame.NEW_WINDOW_WIDTH,\r
-                                   AlignFrame.NEW_WINDOW_HEIGHT);\r
-          af.statusBar.setText("Successfully pasted alignment file");\r
-          try\r
-          {\r
-            af.setMaximum(jalview.bin.Cache.getDefault("SHOW_FULLSCREEN", false));\r
-          }\r
-          catch (Exception ex)\r
-          {}\r
-        }\r
-        else\r
-        {\r
-          for (int i = 0; i < sequences.length; i++)\r
-          {\r
-            alignFrame.viewport.alignment.addSequence(sequences[i]);\r
-\r
-            ////////////////////////////\r
-            //Dataset needs extension;\r
-            /////////////////////////////\r
-            Sequence ds = new Sequence(sequences[i].getName(),\r
-                                       AlignSeq.extractGaps("-. ",\r
-                sequences[i].getSequence()),\r
-                                       sequences[i].getStart(),\r
-                                       sequences[i].getEnd());\r
-            sequences[i].setDatasetSequence(ds);\r
-            alignFrame.viewport.alignment.getDataset().addSequence(ds);\r
-          }\r
-          alignFrame.viewport.setEndSeq(alignFrame.viewport.alignment.\r
-                                        getHeight());\r
-          alignFrame.viewport.alignment.getWidth();\r
-          alignFrame.viewport.firePropertyChange("alignment", null,\r
-                                                 alignFrame.viewport.\r
-                                                 getAlignment().getSequences());\r
-\r
-        }\r
-\r
-        if (database.getSelectedItem().equals("PDB"))\r
-        {\r
-          // Parse out the ids from the structured names\r
-          boolean errors = false;\r
-          for (int i = 0; i < sequences.length; i++)\r
-          {\r
-            PDBEntry entry = new PDBEntry();\r
-            com.stevesoft.pat.Regex idbits = new com.stevesoft.pat.Regex(\r
-                "PDB\\|([0-9A-z]{4})\\|(.)");\r
-            if (idbits.search(sequences[i].getName()))\r
-            {\r
-              String pdbid = idbits.substring(1);\r
-              String pdbccode = idbits.substring(2);\r
-              // Construct the PDBEntry\r
-              entry.setId(pdbid);\r
-              if (entry.getProperty() == null)\r
-                entry.setProperty(new Hashtable());\r
-              entry.getProperty().put("chains",\r
-                                      pdbccode\r
-                                      + "=" + sequences[i].getStart()\r
-                                      + "-" + sequences[i].getEnd());\r
-              sequences[i].getDatasetSequence().addPDBId(entry);\r
-\r
-              // We make a DBRefEtntry because we have obtained the PDB file from a verifiable source\r
-              // JBPNote - PDB DBRefEntry should also carry the chain and mapping information\r
-              DBRefEntry dbentry = new DBRefEntry("PDB","0",pdbid);\r
-              sequences[i].getDatasetSequence().addDBRef(dbentry);\r
-            }\r
-            else\r
-            {\r
-              // don't add an entry for this chain, but this is probably a bug\r
-              // that the user should know about.\r
-              jalview.bin.Cache.log.warn(\r
-                  "No PDBEntry constructed for sequence " + i + " : " +\r
-                  sequences[i].getName());\r
-              errors = true;\r
-            }\r
-          }\r
-          if (errors)\r
-            jalview.bin.Cache.log.warn(\r
-                "Query string that resulted in PDBEntry construction failure was :\n" +\r
-                textfield.getText());\r
-        }\r
-\r
-      }\r
-      else\r
-        showErrorMessage("Error retrieving " + textfield.getText()\r
-                         + " from " + database.getSelectedItem());\r
-    }\r
-\r
-    return sequences;\r
-\r
-  }\r
-\r
-  void showErrorMessage(String error)\r
-  {\r
-    resetDialog();\r
-    JOptionPane.showInternalMessageDialog(Desktop.desktop,\r
-                                          error, "Error Retrieving Data",\r
-                                          JOptionPane.WARNING_MESSAGE);\r
-    return;\r
-  }\r
-}\r
-\r
+/*
+ * Jalview - A Sequence Alignment Editor and Viewer (Version 2.9)
+ * Copyright (C) 2015 The Jalview Authors
+ * 
+ * This file is part of Jalview.
+ * 
+ * Jalview is free software: you can redistribute it and/or
+ * modify it under the terms of the GNU General Public License 
+ * as published by the Free Software Foundation, either version 3
+ * of the License, or (at your option) any later version.
+ *  
+ * Jalview is distributed in the hope that it will be useful, but 
+ * WITHOUT ANY WARRANTY; without even the implied warranty 
+ * of MERCHANTABILITY or FITNESS FOR A PARTICULAR 
+ * PURPOSE.  See the GNU General Public License for more details.
+ * 
+ * You should have received a copy of the GNU General Public License
+ * along with Jalview.  If not, see <http://www.gnu.org/licenses/>.
+ * The Jalview Authors are detailed in the 'AUTHORS' file.
+ */
+package jalview.gui;
+
+import jalview.datamodel.AlignmentI;
+import jalview.datamodel.DBRefEntry;
+import jalview.datamodel.DBRefSource;
+import jalview.datamodel.SequenceFeature;
+import jalview.datamodel.SequenceI;
+import jalview.io.FormatAdapter;
+import jalview.io.IdentifyFile;
+import jalview.util.DBRefUtils;
+import jalview.util.MessageManager;
+import jalview.ws.dbsources.das.api.DasSourceRegistryI;
+import jalview.ws.seqfetcher.DbSourceProxy;
+
+import java.awt.BorderLayout;
+import java.awt.Font;
+import java.awt.event.ActionEvent;
+import java.awt.event.ActionListener;
+import java.awt.event.KeyAdapter;
+import java.awt.event.KeyEvent;
+import java.util.ArrayList;
+import java.util.Arrays;
+import java.util.Iterator;
+import java.util.List;
+
+import javax.swing.JButton;
+import javax.swing.JCheckBox;
+import javax.swing.JInternalFrame;
+import javax.swing.JLabel;
+import javax.swing.JOptionPane;
+import javax.swing.JPanel;
+import javax.swing.JScrollPane;
+import javax.swing.JTextArea;
+import javax.swing.SwingConstants;
+import javax.swing.tree.DefaultMutableTreeNode;
+
+import com.stevesoft.pat.Regex;
+
+public class SequenceFetcher extends JPanel implements Runnable
+{
+  JLabel dbeg = new JLabel();
+
+  JDatabaseTree database;
+
+  JButton databaseButt;
+
+  JLabel jLabel1 = new JLabel();
+
+  JCheckBox replacePunctuation = new JCheckBox();
+
+  JButton ok = new JButton();
+
+  JButton clear = new JButton();
+
+  JButton example = new JButton();
+
+  JButton close = new JButton();
+
+  JPanel jPanel1 = new JPanel();
+
+  JTextArea textArea = new JTextArea();
+
+  JScrollPane jScrollPane1 = new JScrollPane();
+
+  JPanel jPanel2 = new JPanel();
+
+  JPanel jPanel3 = new JPanel();
+
+  JPanel jPanel4 = new JPanel();
+
+  BorderLayout borderLayout1 = new BorderLayout();
+
+  BorderLayout borderLayout2 = new BorderLayout();
+
+  BorderLayout borderLayout3 = new BorderLayout();
+
+  JInternalFrame frame;
+
+  IProgressIndicator guiWindow;
+
+  AlignFrame alignFrame;
+
+  StringBuffer result;
+
+  final String noDbSelected = "-- Select Database --";
+
+  private static jalview.ws.SequenceFetcher sfetch = null;
+
+  private static long lastDasSourceRegistry = -3;
+
+  private static DasSourceRegistryI dasRegistry = null;
+
+  private static boolean _initingFetcher = false;
+
+  private static Thread initingThread = null;
+
+  int debounceTrap = 0;
+
+  /**
+   * Blocking method that initialises and returns the shared instance of the
+   * SequenceFetcher client
+   * 
+   * @param guiWindow
+   *          - where the initialisation delay message should be shown
+   * @return the singleton instance of the sequence fetcher client
+   */
+  public static jalview.ws.SequenceFetcher getSequenceFetcherSingleton(
+          final IProgressIndicator guiWindow)
+  {
+    if (_initingFetcher && initingThread != null && initingThread.isAlive())
+    {
+      if (guiWindow != null)
+      {
+        guiWindow
+                .setProgressBar(
+                        MessageManager
+                                .getString("status.waiting_sequence_database_fetchers_init"),
+                        Thread.currentThread().hashCode());
+      }
+      // initting happening on another thread - so wait around to see if it
+      // finishes.
+      while (_initingFetcher && initingThread != null
+              && initingThread.isAlive())
+      {
+        try
+        {
+          Thread.sleep(10);
+        } catch (Exception e)
+        {
+        }
+        ;
+      }
+      if (guiWindow != null)
+      {
+        guiWindow
+                .setProgressBar(
+                        MessageManager
+                                .getString("status.waiting_sequence_database_fetchers_init"),
+                        Thread.currentThread().hashCode());
+      }
+    }
+    if (sfetch == null
+            || dasRegistry != jalview.bin.Cache.getDasSourceRegistry()
+            || lastDasSourceRegistry != (jalview.bin.Cache
+                    .getDasSourceRegistry().getDasRegistryURL() + jalview.bin.Cache
+                    .getDasSourceRegistry().getLocalSourceString())
+                    .hashCode())
+    {
+      _initingFetcher = true;
+      initingThread = Thread.currentThread();
+      /**
+       * give a visual indication that sequence fetcher construction is occuring
+       */
+      if (guiWindow != null)
+      {
+        guiWindow.setProgressBar(MessageManager
+                .getString("status.init_sequence_database_fetchers"),
+                Thread.currentThread().hashCode());
+      }
+      dasRegistry = jalview.bin.Cache.getDasSourceRegistry();
+      dasRegistry.refreshSources();
+
+      jalview.ws.SequenceFetcher sf = new jalview.ws.SequenceFetcher();
+      if (guiWindow != null)
+      {
+        guiWindow.setProgressBar(null, Thread.currentThread().hashCode());
+      }
+      lastDasSourceRegistry = (dasRegistry.getDasRegistryURL() + dasRegistry
+              .getLocalSourceString()).hashCode();
+      sfetch = sf;
+      _initingFetcher = false;
+      initingThread = null;
+    }
+    return sfetch;
+  }
+
+  private IProgressIndicator progressIndicator;
+
+  public SequenceFetcher(IProgressIndicator guiIndic)
+  {
+    this.progressIndicator = guiIndic;
+    final SequenceFetcher us = this;
+    // launch initialiser thread
+    Thread sf = new Thread(new Runnable()
+    {
+
+      @Override
+      public void run()
+      {
+        if (getSequenceFetcherSingleton(progressIndicator) != null)
+        {
+          us.initGui(progressIndicator);
+        }
+        else
+        {
+          javax.swing.SwingUtilities.invokeLater(new Runnable()
+          {
+            @Override
+            public void run()
+            {
+              JOptionPane
+                      .showInternalMessageDialog(
+                              Desktop.desktop,
+                              MessageManager
+                                      .getString("warn.couldnt_create_sequence_fetcher_client"),
+                              MessageManager
+                                      .getString("label.couldnt_create_sequence_fetcher"),
+                              JOptionPane.ERROR_MESSAGE);
+            }
+          });
+
+          // raise warning dialog
+        }
+      }
+    });
+    sf.start();
+  }
+
+  private class DatabaseAuthority extends DefaultMutableTreeNode
+  {
+
+  };
+
+  private class DatabaseSource extends DefaultMutableTreeNode
+  {
+
+  };
+
+  /**
+   * called by thread spawned by constructor
+   * 
+   * @param guiWindow
+   */
+  private void initGui(IProgressIndicator guiWindow)
+  {
+    this.guiWindow = guiWindow;
+    if (guiWindow instanceof AlignFrame)
+    {
+      alignFrame = (AlignFrame) guiWindow;
+    }
+    database = new JDatabaseTree(sfetch);
+    try
+    {
+      jbInit();
+    } catch (Exception ex)
+    {
+      ex.printStackTrace();
+    }
+
+    frame = new JInternalFrame();
+    frame.setContentPane(this);
+    if (new jalview.util.Platform().isAMac())
+    {
+      Desktop.addInternalFrame(frame, getFrameTitle(), 400, 240);
+    }
+    else
+    {
+      Desktop.addInternalFrame(frame, getFrameTitle(), 400, 180);
+    }
+  }
+
+  private String getFrameTitle()
+  {
+    return ((alignFrame == null) ? MessageManager
+            .getString("label.new_sequence_fetcher") : MessageManager
+            .getString("label.additional_sequence_fetcher"));
+  }
+
+  private void jbInit() throws Exception
+  {
+    this.setLayout(borderLayout2);
+
+    database.setFont(JvSwingUtils.getLabelFont());
+    dbeg.setFont(new java.awt.Font("Verdana", Font.BOLD, 11));
+    jLabel1.setFont(new java.awt.Font("Verdana", Font.ITALIC, 11));
+    jLabel1.setHorizontalAlignment(SwingConstants.CENTER);
+    jLabel1.setText(MessageManager
+            .getString("label.separate_multiple_accession_ids"));
+
+    replacePunctuation.setHorizontalAlignment(SwingConstants.CENTER);
+    replacePunctuation
+            .setFont(new java.awt.Font("Verdana", Font.ITALIC, 11));
+    replacePunctuation.setText(MessageManager
+            .getString("label.replace_commas_semicolons"));
+    ok.setText(MessageManager.getString("action.ok"));
+    ok.addActionListener(new ActionListener()
+    {
+      @Override
+      public void actionPerformed(ActionEvent e)
+      {
+        ok_actionPerformed();
+      }
+    });
+    clear.setText(MessageManager.getString("action.clear"));
+    clear.addActionListener(new ActionListener()
+    {
+      @Override
+      public void actionPerformed(ActionEvent e)
+      {
+        clear_actionPerformed();
+      }
+    });
+
+    example.setText(MessageManager.getString("label.example"));
+    example.addActionListener(new ActionListener()
+    {
+      @Override
+      public void actionPerformed(ActionEvent e)
+      {
+        example_actionPerformed();
+      }
+    });
+    close.setText(MessageManager.getString("action.close"));
+    close.addActionListener(new ActionListener()
+    {
+      @Override
+      public void actionPerformed(ActionEvent e)
+      {
+        close_actionPerformed(e);
+      }
+    });
+    textArea.setFont(JvSwingUtils.getLabelFont());
+    textArea.setLineWrap(true);
+    textArea.addKeyListener(new KeyAdapter()
+    {
+      @Override
+      public void keyPressed(KeyEvent e)
+      {
+        if (e.getKeyCode() == KeyEvent.VK_ENTER)
+        {
+          ok_actionPerformed();
+        }
+      }
+    });
+    jPanel3.setLayout(borderLayout1);
+    borderLayout1.setVgap(5);
+    jPanel1.add(ok);
+    jPanel1.add(example);
+    jPanel1.add(clear);
+    jPanel1.add(close);
+    jPanel3.add(jPanel2, java.awt.BorderLayout.CENTER);
+    jPanel2.setLayout(borderLayout3);
+    databaseButt = database.getDatabaseSelectorButton();
+    databaseButt.setFont(JvSwingUtils.getLabelFont());
+    database.addActionListener(new ActionListener()
+    {
+      @Override
+      public void actionPerformed(ActionEvent e)
+      {
+        debounceTrap++;
+        String currentSelection = database.getSelectedItem();
+        if (!currentSelection.equalsIgnoreCase("pdb"))
+        {
+          otherSourceAction();
+        }
+        if (currentSelection.equalsIgnoreCase("pdb")
+                && (database.action == KeyEvent.VK_ENTER || ((debounceTrap % 2) == 0)))
+        {
+          pdbSourceAction();
+        }
+        database.action = -1;
+      }
+    });
+
+    dbeg.setText("");
+    jPanel2.add(databaseButt, java.awt.BorderLayout.NORTH);
+    jPanel2.add(dbeg, java.awt.BorderLayout.CENTER);
+    JPanel jPanel2a = new JPanel(new BorderLayout());
+    jPanel2a.add(jLabel1, java.awt.BorderLayout.NORTH);
+    jPanel2a.add(replacePunctuation, java.awt.BorderLayout.SOUTH);
+    jPanel2.add(jPanel2a, java.awt.BorderLayout.SOUTH);
+    // jPanel2.setPreferredSize(new Dimension())
+    jPanel3.add(jScrollPane1, java.awt.BorderLayout.CENTER);
+    this.add(jPanel1, java.awt.BorderLayout.SOUTH);
+    this.add(jPanel3, java.awt.BorderLayout.CENTER);
+    this.add(jPanel2, java.awt.BorderLayout.NORTH);
+    jScrollPane1.getViewport().add(textArea);
+
+  }
+
+  private void pdbSourceAction()
+  {
+    databaseButt.setText(database.getSelectedItem());
+    new PDBSearchPanel(this);
+    frame.dispose();
+  }
+
+  private void otherSourceAction()
+  {
+    try
+    {
+      databaseButt.setText(database.getSelectedItem()
+              + (database.getSelectedSources().size() > 1 ? " (and "
+                      + database.getSelectedSources().size() + " others)"
+                      : ""));
+      String eq = database.getExampleQueries();
+      dbeg.setText(MessageManager.formatMessage(
+              "label.example_query_param", new String[] { eq }));
+      boolean enablePunct = !(eq != null && eq.indexOf(",") > -1);
+      for (DbSourceProxy dbs : database.getSelectedSources())
+      {
+        if (dbs instanceof jalview.ws.dbsources.das.datamodel.DasSequenceSource)
+        {
+          enablePunct = false;
+          break;
+        }
+      }
+      replacePunctuation.setEnabled(enablePunct);
+
+    } catch (Exception ex)
+    {
+      dbeg.setText("");
+      replacePunctuation.setEnabled(true);
+    }
+    jPanel2.repaint();
+  }
+
+  protected void example_actionPerformed()
+  {
+    DbSourceProxy db = null;
+    try
+    {
+      textArea.setText(database.getExampleQueries());
+    } catch (Exception ex)
+    {
+    }
+    jPanel3.repaint();
+  }
+
+  protected void clear_actionPerformed()
+  {
+    textArea.setText("");
+    jPanel3.repaint();
+  }
+
+  public void close_actionPerformed(ActionEvent e)
+  {
+    try
+    {
+      frame.setClosed(true);
+    } catch (Exception ex)
+    {
+    }
+  }
+
+  public void ok_actionPerformed()
+  {
+    databaseButt.setEnabled(false);
+    example.setEnabled(false);
+    textArea.setEnabled(false);
+    ok.setEnabled(false);
+    close.setEnabled(false);
+
+    Thread worker = new Thread(this);
+    worker.start();
+  }
+
+  private void resetDialog()
+  {
+    databaseButt.setEnabled(true);
+    example.setEnabled(true);
+    textArea.setEnabled(true);
+    ok.setEnabled(true);
+    close.setEnabled(true);
+  }
+
+  @Override
+  public void run()
+  {
+    String error = "";
+    if (!database.hasSelection())
+    {
+      error += "Please select the source database\n";
+    }
+    // TODO: make this transformation more configurable
+    com.stevesoft.pat.Regex empty;
+    if (replacePunctuation.isEnabled() && replacePunctuation.isSelected())
+    {
+      empty = new com.stevesoft.pat.Regex(
+      // replace commas and spaces with a semicolon
+              "(\\s|[,; ])+", ";");
+    }
+    else
+    {
+      // just turn spaces and semicolons into single semicolons
+      empty = new com.stevesoft.pat.Regex("(\\s|[; ])+", ";");
+    }
+    textArea.setText(empty.replaceAll(textArea.getText()));
+    // see if there's anthing to search with
+    if (!new com.stevesoft.pat.Regex("[A-Za-z0-9_.]").search(textArea
+            .getText()))
+    {
+      error += "Please enter a (semi-colon separated list of) database id(s)";
+    }
+    if (error.length() > 0)
+    {
+      showErrorMessage(error);
+      resetDialog();
+      return;
+    }
+    // indicate if successive sources should be merged into one alignment.
+    boolean addToLast = false;
+    ArrayList<String> aresultq = new ArrayList<String>(), presultTitle = new ArrayList<String>();
+    ArrayList<AlignmentI> presult = new ArrayList<AlignmentI>(), aresult = new ArrayList<AlignmentI>();
+    Iterator<DbSourceProxy> proxies = database.getSelectedSources()
+            .iterator();
+    String[] qries;
+    List<String> nextfetch = Arrays.asList(qries = textArea.getText()
+            .split(";"));
+    Iterator<String> en = Arrays.asList(new String[0]).iterator();
+    int nqueries = qries.length;
+    while (proxies.hasNext() && (en.hasNext() || nextfetch.size() > 0))
+    {
+      if (!en.hasNext() && nextfetch.size() > 0)
+      {
+        en = nextfetch.iterator();
+        nqueries = nextfetch.size();
+        // save the remaining queries in the original array
+        qries = nextfetch.toArray(new String[nqueries]);
+        nextfetch = new ArrayList<String>();
+      }
+
+      DbSourceProxy proxy = proxies.next();
+      boolean isAliSource = false;
+      try
+      {
+        // update status
+        guiWindow
+                .setProgressBar(MessageManager.formatMessage(
+                        "status.fetching_sequence_queries_from",
+                        new String[] {
+                            Integer.valueOf(nqueries).toString(),
+                            proxy.getDbName() }), Thread.currentThread()
+                        .hashCode());
+        isAliSource = proxy.isA(DBRefSource.ALIGNMENTDB);
+        if (proxy.getAccessionSeparator() == null)
+        {
+          while (en.hasNext())
+          {
+            String item = en.next();
+            try
+            {
+              if (aresult != null)
+              {
+                try
+                {
+                  // give the server a chance to breathe
+                  Thread.sleep(5);
+                } catch (Exception e)
+                {
+                  //
+                }
+
+              }
+
+              AlignmentI indres = null;
+              try
+              {
+                indres = proxy.getSequenceRecords(item);
+              } catch (OutOfMemoryError oome)
+              {
+                new OOMWarning("fetching " + item + " from "
+                        + proxy.getDbName(), oome, this);
+              }
+              if (indres != null)
+              {
+                aresultq.add(item);
+                aresult.add(indres);
+              }
+              else
+              {
+                nextfetch.add(item);
+              }
+            } catch (Exception e)
+            {
+              jalview.bin.Cache.log.info("Error retrieving " + item
+                      + " from " + proxy.getDbName(), e);
+              nextfetch.add(item);
+            }
+          }
+        }
+        else
+        {
+          StringBuffer multiacc = new StringBuffer();
+          ArrayList<String> tosend = new ArrayList<String>();
+          while (en.hasNext())
+          {
+            String nel = en.next();
+            tosend.add(nel);
+            multiacc.append(nel);
+            if (en.hasNext())
+            {
+              multiacc.append(proxy.getAccessionSeparator());
+            }
+          }
+          try
+          {
+            AlignmentI rslt;
+            SequenceI[] rs;
+            List<String> nores = new ArrayList<String>();
+            rslt = proxy.getSequenceRecords(multiacc.toString());
+            if (rslt == null || rslt.getHeight() == 0)
+            {
+              // no results - pass on all queries to next source
+              nextfetch.addAll(tosend);
+            }
+            else
+            {
+              aresultq.add(multiacc.toString());
+              aresult.add(rslt);
+
+              rs = rslt.getSequencesArray();
+              // search for each query in the dbrefs associated with each
+              // sequence
+              // returned.
+              // ones we do not find will be used to query next source (if any)
+              for (String q : tosend)
+              {
+                DBRefEntry dbr = new DBRefEntry(), found[] = null;
+                dbr.setSource(proxy.getDbSource());
+                dbr.setVersion(null);
+                if (proxy.getAccessionValidator() != null)
+                {
+                  Regex vgr = proxy.getAccessionValidator();
+                  vgr.search(q);
+                  if (vgr.numSubs() > 0)
+                  {
+                    dbr.setAccessionId(vgr.stringMatched(1));
+                  }
+                  else
+                  {
+                    dbr.setAccessionId(vgr.stringMatched());
+                  }
+                }
+                else
+                {
+                  dbr.setAccessionId(q);
+                }
+                boolean rfound = false;
+                for (int r = 0; r < rs.length; r++)
+                {
+                  if (rs[r] != null
+                          && (found = DBRefUtils.searchRefs(
+                                  rs[r].getDBRef(), dbr)) != null
+                          && found.length > 0)
+                  {
+                    rfound = true;
+                    rs[r] = null;
+                    continue;
+                  }
+                }
+                if (!rfound)
+                {
+                  nextfetch.add(q);
+                }
+              }
+            }
+          } catch (OutOfMemoryError oome)
+          {
+            new OOMWarning("fetching " + multiacc + " from "
+                    + database.getSelectedItem(), oome, this);
+          }
+        }
+
+      } catch (Exception e)
+      {
+        showErrorMessage("Error retrieving " + textArea.getText()
+                + " from " + database.getSelectedItem());
+        // error
+        // +="Couldn't retrieve sequences from "+database.getSelectedItem();
+        System.err.println("Retrieval failed for source ='"
+                + database.getSelectedItem() + "' and query\n'"
+                + textArea.getText() + "'\n");
+        e.printStackTrace();
+      } catch (OutOfMemoryError e)
+      {
+        // resets dialog box - so we don't use OOMwarning here.
+        showErrorMessage("Out of Memory when retrieving "
+                + textArea.getText()
+                + " from "
+                + database.getSelectedItem()
+                + "\nPlease see the Jalview FAQ for instructions for increasing the memory available to Jalview.\n");
+        e.printStackTrace();
+      } catch (Error e)
+      {
+        showErrorMessage("Serious Error retrieving " + textArea.getText()
+                + " from " + database.getSelectedItem());
+        e.printStackTrace();
+      }
+      // Stack results ready for opening in alignment windows
+      if (aresult != null && aresult.size() > 0)
+      {
+        AlignmentI ar = null;
+        if (isAliSource)
+        {
+          addToLast = false;
+          // new window for each result
+          while (aresult.size() > 0)
+          {
+            presult.add(aresult.remove(0));
+            presultTitle.add(aresultq.remove(0) + " "
+                    + getDefaultRetrievalTitle());
+          }
+        }
+        else
+        {
+          String titl = null;
+          if (addToLast && presult.size() > 0)
+          {
+            ar = presult.remove(presult.size() - 1);
+            titl = presultTitle.remove(presultTitle.size() - 1);
+          }
+          // concatenate all results in one window
+          while (aresult.size() > 0)
+          {
+            if (ar == null)
+            {
+              ar = aresult.remove(0);
+            }
+            else
+            {
+              ar.append(aresult.remove(0));
+            }
+            ;
+          }
+          addToLast = true;
+          presult.add(ar);
+          presultTitle.add(titl);
+        }
+      }
+      guiWindow.setProgressBar(MessageManager
+              .getString("status.finshed_querying"), Thread.currentThread()
+              .hashCode());
+    }
+    guiWindow.setProgressBar(
+            (presult.size() > 0) ? MessageManager
+                    .getString("status.parsing_results") : MessageManager
+                    .getString("status.processing"), Thread.currentThread()
+                    .hashCode());
+    // process results
+    while (presult.size() > 0)
+    {
+      parseResult(presult.remove(0), presultTitle.remove(0), null);
+    }
+    // only remove visual delay after we finished parsing.
+    guiWindow.setProgressBar(null, Thread.currentThread().hashCode());
+    if (nextfetch.size() > 0)
+    {
+      StringBuffer sb = new StringBuffer();
+      sb.append("Didn't retrieve the following "
+              + (nextfetch.size() == 1 ? "query" : nextfetch.size()
+                      + " queries") + ": \n");
+      int l = sb.length(), lr = 0;
+      for (String s : nextfetch)
+      {
+        if (l != sb.length())
+        {
+          sb.append("; ");
+        }
+        if (lr - sb.length() > 40)
+        {
+          sb.append("\n");
+        }
+        sb.append(s);
+      }
+      showErrorMessage(sb.toString());
+    }
+    resetDialog();
+  }
+
+  AlignmentI parseResult(String result, String title)
+  {
+    String format = new IdentifyFile().Identify(result, "Paste");
+    AlignmentI sequences = null;
+    if (FormatAdapter.isValidFormat(format))
+    {
+      sequences = null;
+      try
+      {
+        sequences = new FormatAdapter().readFile(result.toString(),
+                "Paste", format);
+      } catch (Exception ex)
+      {
+      }
+
+      if (sequences != null)
+      {
+        return parseResult(sequences, title, format);
+      }
+    }
+    else
+    {
+      showErrorMessage("Error retrieving " + textArea.getText() + " from "
+              + database.getSelectedItem());
+    }
+
+    return null;
+  }
+
+  /**
+   * 
+   * @return a standard title for any results retrieved using the currently
+   *         selected source and settings
+   */
+  public String getDefaultRetrievalTitle()
+  {
+    return "Retrieved from " + database.getSelectedItem();
+  }
+
+  AlignmentI parseResult(AlignmentI al, String title,
+          String currentFileFormat)
+  {
+
+    if (al != null && al.getHeight() > 0)
+    {
+      if (title == null)
+      {
+        title = getDefaultRetrievalTitle();
+      }
+      if (alignFrame == null)
+      {
+        AlignFrame af = new AlignFrame(al, AlignFrame.DEFAULT_WIDTH,
+                AlignFrame.DEFAULT_HEIGHT);
+        if (currentFileFormat != null)
+        {
+          af.currentFileFormat = currentFileFormat; // WHAT IS THE DEFAULT
+          // FORMAT FOR
+          // NON-FormatAdapter Sourced
+          // Alignments?
+        }
+
+        SequenceFeature[] sfs = null;
+        List<SequenceI> alsqs;
+        synchronized (alsqs = al.getSequences())
+        {
+          for (SequenceI sq : alsqs)
+          {
+            if ((sfs = sq.getSequenceFeatures()) != null)
+            {
+              if (sfs.length > 0)
+              {
+                af.setShowSeqFeatures(true);
+                break;
+              }
+            }
+
+          }
+        }
+        Desktop.addInternalFrame(af, title, AlignFrame.DEFAULT_WIDTH,
+                AlignFrame.DEFAULT_HEIGHT);
+
+        af.statusBar.setText(MessageManager
+                .getString("label.successfully_pasted_alignment_file"));
+
+        try
+        {
+          af.setMaximum(jalview.bin.Cache.getDefault("SHOW_FULLSCREEN",
+                  false));
+        } catch (Exception ex)
+        {
+        }
+      }
+      else
+      {
+        alignFrame.viewport.addAlignment(al, title);
+      }
+    }
+    return al;
+  }
+
+  void showErrorMessage(final String error)
+  {
+    resetDialog();
+    javax.swing.SwingUtilities.invokeLater(new Runnable()
+    {
+      @Override
+      public void run()
+      {
+        JOptionPane.showInternalMessageDialog(Desktop.desktop, error,
+                MessageManager.getString("label.error_retrieving_data"),
+                JOptionPane.WARNING_MESSAGE);
+      }
+    });
+  }
+
+  public IProgressIndicator getProgressIndicator()
+  {
+    return progressIndicator;
+  }
+
+  public void setProgressIndicator(IProgressIndicator progressIndicator)
+  {
+    this.progressIndicator = progressIndicator;
+  }
+}