WSTester updated to work plus hopefully all the other changes that need to go into...
[jabaws.git] / binaries / src / ViennaRNA / Progs / RNAplex_cmdl.c
diff --git a/binaries/src/ViennaRNA/Progs/RNAplex_cmdl.c b/binaries/src/ViennaRNA/Progs/RNAplex_cmdl.c
new file mode 100644 (file)
index 0000000..c7ddf34
--- /dev/null
@@ -0,0 +1,1689 @@
+/*
+  File autogenerated by gengetopt version 2.22.5
+  generated with the following command:
+  gengetopt -i RNAplex.ggo --file-name=RNAplex_cmdl --include-getopt --default-optional --func-name=RNAplex_cmdline_parser --arg-struct-name=RNAplex_args_info
+
+  The developers of gengetopt consider the fixed text that goes in all
+  gengetopt output files to be in the public domain:
+  we make no copyright claims on it.
+*/
+
+/* If we use autoconf.  */
+#ifdef HAVE_CONFIG_H
+#include "config.h"
+#endif
+
+#include <stdio.h>
+#include <stdlib.h>
+#include <string.h>
+
+#ifndef FIX_UNUSED
+#define FIX_UNUSED(X) (void) (X) /* avoid warnings for unused params */
+#endif
+
+
+#include "RNAplex_cmdl.h"
+
+const char *RNAplex_args_info_purpose = "Find targets of a query RNA";
+
+const char *RNAplex_args_info_usage = "Usage: RNAplex [options]\n";
+
+const char *RNAplex_args_info_description = "reads two RNA sequences from stdin or <filename> and computes optimal and \nsuboptimal secondary structures for their hybridization. The calculation is \nsimplified by allowing only inter-molecular base pairs. Accessibility effects \ncan be estimated by RNAplex if a RNAplfold accessibility profile is provided. \nThe computed optimal and suboptimal structure are written to stdout, one \nstructure per line. Each line consist of: The structure in dot bracket format \nwith a \"&\" separating the two strands. The range of the structure in the two \nsequences in the format  \"from,to : from,to\"; the energy of duplex structure \nin kcal/mol.\nThe format is especially useful for computing the hybrid structure between a \nsmall probe sequence and a long target sequence.\n";
+
+const char *RNAplex_args_info_detailed_help[] = {
+  "  -h, --help                    Print help and exit",
+  "      --detailed-help           Print help, including all details and hidden \n                                  options, and exit",
+  "      --version                 Print version and exit",
+  "\nInput Options:",
+  "  Below are command line options which alter the general input behavior of this \n  program\n",
+  "  -q, --query=STRING            File containing the query sequence.\n",
+  "  Input sequences can be given piped to RNAplex or given in a query file with \n  the -q option. Note that the -q option implies that the -t option is also \n  used\n\n",
+  "  -t, --target=STRING           File containing the target sequence.\n",
+  "  Input sequences can be given piped to RNAplex or given in a target file with \n  the -t option. Note that the -t option implies that the -q option is also \n  used\n\n",
+  "  -a, --accessibility-dir=STRING\n                                Location of the accessibility profiles.\n",
+  "  This option switches the accessibility modes on and indicates in which \n  directory accessibility profiles as generated by RNAplfold can be found\n\n",
+  "  -b, --binary                  Allow the reading and parsing of memory dumped \n                                  opening energy file\n                                    (default=off)",
+  "  The -b option allows to read and process opening energy files which are saved \n  in binary format\n   This can reduce by a factor of 500x-1000x the time needed to process those \n  files. RNAplex recognizes the corresponding opening energy files by looking \n  for files named after the sequence and containing the suffix _openen_bin. \n  Please look at the man page of RNAplfold if you need more information on how \n  to produce binary opening energy files.\n\n",
+  "  -P, --paramFile=paramfile     Read energy parameters from paramfile, instead \n                                  of using the default parameter set.\n",
+  "  A sample parameter file should accompany your distribution.\n  See the RNAlib documentation for details on the file format.\n\n",
+  "\nAlgorithms:",
+  "  Options which alter the computing behaviour of RNAplex.\n",
+  "  -T, --temp=DOUBLE             Rescale energy parameters to a temperature T. \n                                  Default is 37C.\n\n",
+  "  -l, --interaction-length=INT  Maximal length of an interaction\n                                    (default=`40')",
+  "  Maximal allowed length of an interaction\n\n",
+  "  -c, --extension-cost=INT      Cost to add to each nucleotide in a duplex\n                                    (default=`0')",
+  "  Cost of extending a duplex by one nucleotide. Allows to find compact \n  duplexes, having few/small bulges or interior loops Only useful when no \n  accessibility profiles are available. This option is disabled if \n  accessibility profiles are used (-a option)\n\n",
+  "  -p, --probe-mode              Compute Tm for probes  (default=off)",
+  "  Use this option if you want to compute the melting temperature of your probes\n\n",
+  "  -Q, --probe-concentration=DOUBLE\n                                Set the probe concentration for the Tm \n                                  computation\n\n                                    (default=`0.1')",
+  "  -N, --na-concentration=DOUBLE Set the Na+ concentration for the Tm \n                                  computation\n\n                                    (default=`1.0')",
+  "  -M, --mg-concentration=DOUBLE Set the Mg2+ concentration for the Tm \n                                  computation\n\n                                    (default=`1.0')",
+  "  -K, --k-concentration=DOUBLE  Set the K+ concentration for the Tm computation\n\n                                    (default=`1.0')",
+  "  -U, --tris-concentration=DOUBLE\n                                Set the tris+ concentration for the Tm \n                                  computation\n\n                                    (default=`1.0')",
+  "  -f, --fast-folding=INT        Speedup of the target search\n                                    (default=`0')",
+  "  This option allows to decide if the backtracking has to be done (-f 0, -f 2) \n  or not (-f 1). For -f 0 the structure is computed based on the standard \n  energy model. This is the slowest and most precise mode of RNAplex. With -f \n  2, the structure is computed based on the approximated plex model. If a lot \n  of targets are returned this is can greatly improve the runtime of RNAplex. \n  -f 1 is the fastest mode, as no structure are recomputed \n\n",
+  "  -V, --scale-accessibility=DOUBLE\n                                Rescale all opening energy by a factor V\n                                    (default=`1.0')",
+  "  Scale-factor for the accessibility. If V is set to 1 then the scaling has no \n  effect on the accessibility.\n\n",
+  "  -C, --constraint              Calculate structures subject to constraints.\n                                    (default=off)",
+  "  The program reads first the sequence, then a string containing constraints on \n  the structure for the query sequence encoded with the symbols:\n  . (no constraint for this base)\n  | (the corresponding base has to be paired)\n\n",
+  "  -A, --alignment-mode          Tells RNAplex to compute interactions based on \n                                  alignments\n                                    (default=off)",
+  "  If the A option is set RNAplex expects clustalw files as input for the -q and \n  -t option.\n\n",
+  "  -k, --convert-to-bin          If set, RNAplex will convert all opening energy \n                                  file in a directory set by the -a option into \n                                  binary opening energy files\n                                    (default=off)",
+  "  RNAplex can be used to convert existing text formatted opening energy files \n  into binary formatted files. In this mode RNAplex does not compute \n  interactions.\n\n",
+  "\nOutput:",
+  "  Options that modify the output\n",
+  "  -z, --duplex-distance=INT     Distance between target 3' ends of two \n                                  consecutive duplexes\n                                    (default=`0')",
+  "  Distance between the target 3'ends of two consecutive duplexes. Should be set \n  to the maximal length of interaction to get good results\n   Smaller z leads to larger overlaps between consecutive duplexes.\n\n",
+  "  -e, --energy-threshold=DOUBLE Minimal energy for a duplex to be returned\n                                    (default=`-100000')",
+  "  Energy threshold for a duplex to be returned. The threshold is set on the \n  total energy of interaction, i.e. the hybridization energy corrected for \n  opening energy if -a is set or the energy corrected by -c. If unset, only the \n  mfe will be returned\n\n",
+  "  -I, --produce-ps=STRING       Draw an alignment annotated interaction from \n                                  RNAplex\n",
+  "  This option allows to produce interaction figures in PS-format a la \n  RNAalifold, where base-pair conservation is represented in color-coded \n  format. In this mode no interaction are computed, but the -I option indicates \n  the location of the file containing interactions between two RNA \n  (alignments/sequence) from a previous run. If the -A option is not set a \n  structure figure a la RNAfold with color-coded annotation of the \n  accessibilities is returned\n\n",
+  "  -L, --WindowLength=INT        Tells how large the region around the target \n                                  site should be for redrawing the alignment \n                                  interaction\n                                    (default=`1')",
+  "  This option allow to specify how large the region surrounding the target site \n  should be set when generating the alignment figure of the interaction\n\n",
+  "\nIf in doubt our program is right, nature is at fault.\nComments should be sent to rna@tbi.univie.ac.at.\n",
+    0
+};
+
+static void
+init_help_array(void)
+{
+  RNAplex_args_info_help[0] = RNAplex_args_info_detailed_help[0];
+  RNAplex_args_info_help[1] = RNAplex_args_info_detailed_help[1];
+  RNAplex_args_info_help[2] = RNAplex_args_info_detailed_help[2];
+  RNAplex_args_info_help[3] = RNAplex_args_info_detailed_help[3];
+  RNAplex_args_info_help[4] = RNAplex_args_info_detailed_help[4];
+  RNAplex_args_info_help[5] = RNAplex_args_info_detailed_help[5];
+  RNAplex_args_info_help[6] = RNAplex_args_info_detailed_help[7];
+  RNAplex_args_info_help[7] = RNAplex_args_info_detailed_help[9];
+  RNAplex_args_info_help[8] = RNAplex_args_info_detailed_help[11];
+  RNAplex_args_info_help[9] = RNAplex_args_info_detailed_help[13];
+  RNAplex_args_info_help[10] = RNAplex_args_info_detailed_help[15];
+  RNAplex_args_info_help[11] = RNAplex_args_info_detailed_help[16];
+  RNAplex_args_info_help[12] = RNAplex_args_info_detailed_help[17];
+  RNAplex_args_info_help[13] = RNAplex_args_info_detailed_help[18];
+  RNAplex_args_info_help[14] = RNAplex_args_info_detailed_help[20];
+  RNAplex_args_info_help[15] = RNAplex_args_info_detailed_help[22];
+  RNAplex_args_info_help[16] = RNAplex_args_info_detailed_help[24];
+  RNAplex_args_info_help[17] = RNAplex_args_info_detailed_help[25];
+  RNAplex_args_info_help[18] = RNAplex_args_info_detailed_help[26];
+  RNAplex_args_info_help[19] = RNAplex_args_info_detailed_help[27];
+  RNAplex_args_info_help[20] = RNAplex_args_info_detailed_help[28];
+  RNAplex_args_info_help[21] = RNAplex_args_info_detailed_help[29];
+  RNAplex_args_info_help[22] = RNAplex_args_info_detailed_help[31];
+  RNAplex_args_info_help[23] = RNAplex_args_info_detailed_help[33];
+  RNAplex_args_info_help[24] = RNAplex_args_info_detailed_help[35];
+  RNAplex_args_info_help[25] = RNAplex_args_info_detailed_help[37];
+  RNAplex_args_info_help[26] = RNAplex_args_info_detailed_help[39];
+  RNAplex_args_info_help[27] = RNAplex_args_info_detailed_help[40];
+  RNAplex_args_info_help[28] = RNAplex_args_info_detailed_help[41];
+  RNAplex_args_info_help[29] = RNAplex_args_info_detailed_help[43];
+  RNAplex_args_info_help[30] = RNAplex_args_info_detailed_help[45];
+  RNAplex_args_info_help[31] = RNAplex_args_info_detailed_help[47];
+  RNAplex_args_info_help[32] = RNAplex_args_info_detailed_help[49];
+  RNAplex_args_info_help[33] = 0; 
+  
+}
+
+const char *RNAplex_args_info_help[34];
+
+typedef enum {ARG_NO
+  , ARG_FLAG
+  , ARG_STRING
+  , ARG_INT
+  , ARG_DOUBLE
+} RNAplex_cmdline_parser_arg_type;
+
+static
+void clear_given (struct RNAplex_args_info *args_info);
+static
+void clear_args (struct RNAplex_args_info *args_info);
+
+static int
+RNAplex_cmdline_parser_internal (int argc, char **argv, struct RNAplex_args_info *args_info,
+                        struct RNAplex_cmdline_parser_params *params, const char *additional_error);
+
+
+static char *
+gengetopt_strdup (const char *s);
+
+static
+void clear_given (struct RNAplex_args_info *args_info)
+{
+  args_info->help_given = 0 ;
+  args_info->detailed_help_given = 0 ;
+  args_info->version_given = 0 ;
+  args_info->query_given = 0 ;
+  args_info->target_given = 0 ;
+  args_info->accessibility_dir_given = 0 ;
+  args_info->binary_given = 0 ;
+  args_info->paramFile_given = 0 ;
+  args_info->temp_given = 0 ;
+  args_info->interaction_length_given = 0 ;
+  args_info->extension_cost_given = 0 ;
+  args_info->probe_mode_given = 0 ;
+  args_info->probe_concentration_given = 0 ;
+  args_info->na_concentration_given = 0 ;
+  args_info->mg_concentration_given = 0 ;
+  args_info->k_concentration_given = 0 ;
+  args_info->tris_concentration_given = 0 ;
+  args_info->fast_folding_given = 0 ;
+  args_info->scale_accessibility_given = 0 ;
+  args_info->constraint_given = 0 ;
+  args_info->alignment_mode_given = 0 ;
+  args_info->convert_to_bin_given = 0 ;
+  args_info->duplex_distance_given = 0 ;
+  args_info->energy_threshold_given = 0 ;
+  args_info->produce_ps_given = 0 ;
+  args_info->WindowLength_given = 0 ;
+}
+
+static
+void clear_args (struct RNAplex_args_info *args_info)
+{
+  FIX_UNUSED (args_info);
+  args_info->query_arg = NULL;
+  args_info->query_orig = NULL;
+  args_info->target_arg = NULL;
+  args_info->target_orig = NULL;
+  args_info->accessibility_dir_arg = NULL;
+  args_info->accessibility_dir_orig = NULL;
+  args_info->binary_flag = 0;
+  args_info->paramFile_arg = NULL;
+  args_info->paramFile_orig = NULL;
+  args_info->temp_orig = NULL;
+  args_info->interaction_length_arg = 40;
+  args_info->interaction_length_orig = NULL;
+  args_info->extension_cost_arg = 0;
+  args_info->extension_cost_orig = NULL;
+  args_info->probe_mode_flag = 0;
+  args_info->probe_concentration_arg = 0.1;
+  args_info->probe_concentration_orig = NULL;
+  args_info->na_concentration_arg = 1.0;
+  args_info->na_concentration_orig = NULL;
+  args_info->mg_concentration_arg = 1.0;
+  args_info->mg_concentration_orig = NULL;
+  args_info->k_concentration_arg = 1.0;
+  args_info->k_concentration_orig = NULL;
+  args_info->tris_concentration_arg = 1.0;
+  args_info->tris_concentration_orig = NULL;
+  args_info->fast_folding_arg = 0;
+  args_info->fast_folding_orig = NULL;
+  args_info->scale_accessibility_arg = 1.0;
+  args_info->scale_accessibility_orig = NULL;
+  args_info->constraint_flag = 0;
+  args_info->alignment_mode_flag = 0;
+  args_info->convert_to_bin_flag = 0;
+  args_info->duplex_distance_arg = 0;
+  args_info->duplex_distance_orig = NULL;
+  args_info->energy_threshold_arg = -100000;
+  args_info->energy_threshold_orig = NULL;
+  args_info->produce_ps_arg = NULL;
+  args_info->produce_ps_orig = NULL;
+  args_info->WindowLength_arg = 1;
+  args_info->WindowLength_orig = NULL;
+  
+}
+
+static
+void init_args_info(struct RNAplex_args_info *args_info)
+{
+
+  init_help_array(); 
+  args_info->help_help = RNAplex_args_info_detailed_help[0] ;
+  args_info->detailed_help_help = RNAplex_args_info_detailed_help[1] ;
+  args_info->version_help = RNAplex_args_info_detailed_help[2] ;
+  args_info->query_help = RNAplex_args_info_detailed_help[5] ;
+  args_info->target_help = RNAplex_args_info_detailed_help[7] ;
+  args_info->accessibility_dir_help = RNAplex_args_info_detailed_help[9] ;
+  args_info->binary_help = RNAplex_args_info_detailed_help[11] ;
+  args_info->paramFile_help = RNAplex_args_info_detailed_help[13] ;
+  args_info->temp_help = RNAplex_args_info_detailed_help[17] ;
+  args_info->interaction_length_help = RNAplex_args_info_detailed_help[18] ;
+  args_info->extension_cost_help = RNAplex_args_info_detailed_help[20] ;
+  args_info->probe_mode_help = RNAplex_args_info_detailed_help[22] ;
+  args_info->probe_concentration_help = RNAplex_args_info_detailed_help[24] ;
+  args_info->na_concentration_help = RNAplex_args_info_detailed_help[25] ;
+  args_info->mg_concentration_help = RNAplex_args_info_detailed_help[26] ;
+  args_info->k_concentration_help = RNAplex_args_info_detailed_help[27] ;
+  args_info->tris_concentration_help = RNAplex_args_info_detailed_help[28] ;
+  args_info->fast_folding_help = RNAplex_args_info_detailed_help[29] ;
+  args_info->scale_accessibility_help = RNAplex_args_info_detailed_help[31] ;
+  args_info->constraint_help = RNAplex_args_info_detailed_help[33] ;
+  args_info->alignment_mode_help = RNAplex_args_info_detailed_help[35] ;
+  args_info->convert_to_bin_help = RNAplex_args_info_detailed_help[37] ;
+  args_info->duplex_distance_help = RNAplex_args_info_detailed_help[41] ;
+  args_info->energy_threshold_help = RNAplex_args_info_detailed_help[43] ;
+  args_info->produce_ps_help = RNAplex_args_info_detailed_help[45] ;
+  args_info->WindowLength_help = RNAplex_args_info_detailed_help[47] ;
+  
+}
+
+void
+RNAplex_cmdline_parser_print_version (void)
+{
+  printf ("%s %s\n",
+     (strlen(RNAPLEX_CMDLINE_PARSER_PACKAGE_NAME) ? RNAPLEX_CMDLINE_PARSER_PACKAGE_NAME : RNAPLEX_CMDLINE_PARSER_PACKAGE),
+     RNAPLEX_CMDLINE_PARSER_VERSION);
+}
+
+static void print_help_common(void) {
+  RNAplex_cmdline_parser_print_version ();
+
+  if (strlen(RNAplex_args_info_purpose) > 0)
+    printf("\n%s\n", RNAplex_args_info_purpose);
+
+  if (strlen(RNAplex_args_info_usage) > 0)
+    printf("\n%s\n", RNAplex_args_info_usage);
+
+  printf("\n");
+
+  if (strlen(RNAplex_args_info_description) > 0)
+    printf("%s\n\n", RNAplex_args_info_description);
+}
+
+void
+RNAplex_cmdline_parser_print_help (void)
+{
+  int i = 0;
+  print_help_common();
+  while (RNAplex_args_info_help[i])
+    printf("%s\n", RNAplex_args_info_help[i++]);
+}
+
+void
+RNAplex_cmdline_parser_print_detailed_help (void)
+{
+  int i = 0;
+  print_help_common();
+  while (RNAplex_args_info_detailed_help[i])
+    printf("%s\n", RNAplex_args_info_detailed_help[i++]);
+}
+
+void
+RNAplex_cmdline_parser_init (struct RNAplex_args_info *args_info)
+{
+  clear_given (args_info);
+  clear_args (args_info);
+  init_args_info (args_info);
+}
+
+void
+RNAplex_cmdline_parser_params_init(struct RNAplex_cmdline_parser_params *params)
+{
+  if (params)
+    { 
+      params->override = 0;
+      params->initialize = 1;
+      params->check_required = 1;
+      params->check_ambiguity = 0;
+      params->print_errors = 1;
+    }
+}
+
+struct RNAplex_cmdline_parser_params *
+RNAplex_cmdline_parser_params_create(void)
+{
+  struct RNAplex_cmdline_parser_params *params = 
+    (struct RNAplex_cmdline_parser_params *)malloc(sizeof(struct RNAplex_cmdline_parser_params));
+  RNAplex_cmdline_parser_params_init(params);  
+  return params;
+}
+
+static void
+free_string_field (char **s)
+{
+  if (*s)
+    {
+      free (*s);
+      *s = 0;
+    }
+}
+
+
+static void
+RNAplex_cmdline_parser_release (struct RNAplex_args_info *args_info)
+{
+
+  free_string_field (&(args_info->query_arg));
+  free_string_field (&(args_info->query_orig));
+  free_string_field (&(args_info->target_arg));
+  free_string_field (&(args_info->target_orig));
+  free_string_field (&(args_info->accessibility_dir_arg));
+  free_string_field (&(args_info->accessibility_dir_orig));
+  free_string_field (&(args_info->paramFile_arg));
+  free_string_field (&(args_info->paramFile_orig));
+  free_string_field (&(args_info->temp_orig));
+  free_string_field (&(args_info->interaction_length_orig));
+  free_string_field (&(args_info->extension_cost_orig));
+  free_string_field (&(args_info->probe_concentration_orig));
+  free_string_field (&(args_info->na_concentration_orig));
+  free_string_field (&(args_info->mg_concentration_orig));
+  free_string_field (&(args_info->k_concentration_orig));
+  free_string_field (&(args_info->tris_concentration_orig));
+  free_string_field (&(args_info->fast_folding_orig));
+  free_string_field (&(args_info->scale_accessibility_orig));
+  free_string_field (&(args_info->duplex_distance_orig));
+  free_string_field (&(args_info->energy_threshold_orig));
+  free_string_field (&(args_info->produce_ps_arg));
+  free_string_field (&(args_info->produce_ps_orig));
+  free_string_field (&(args_info->WindowLength_orig));
+  
+  
+
+  clear_given (args_info);
+}
+
+
+static void
+write_into_file(FILE *outfile, const char *opt, const char *arg, const char *values[])
+{
+  FIX_UNUSED (values);
+  if (arg) {
+    fprintf(outfile, "%s=\"%s\"\n", opt, arg);
+  } else {
+    fprintf(outfile, "%s\n", opt);
+  }
+}
+
+
+int
+RNAplex_cmdline_parser_dump(FILE *outfile, struct RNAplex_args_info *args_info)
+{
+  int i = 0;
+
+  if (!outfile)
+    {
+      fprintf (stderr, "%s: cannot dump options to stream\n", RNAPLEX_CMDLINE_PARSER_PACKAGE);
+      return EXIT_FAILURE;
+    }
+
+  if (args_info->help_given)
+    write_into_file(outfile, "help", 0, 0 );
+  if (args_info->detailed_help_given)
+    write_into_file(outfile, "detailed-help", 0, 0 );
+  if (args_info->version_given)
+    write_into_file(outfile, "version", 0, 0 );
+  if (args_info->query_given)
+    write_into_file(outfile, "query", args_info->query_orig, 0);
+  if (args_info->target_given)
+    write_into_file(outfile, "target", args_info->target_orig, 0);
+  if (args_info->accessibility_dir_given)
+    write_into_file(outfile, "accessibility-dir", args_info->accessibility_dir_orig, 0);
+  if (args_info->binary_given)
+    write_into_file(outfile, "binary", 0, 0 );
+  if (args_info->paramFile_given)
+    write_into_file(outfile, "paramFile", args_info->paramFile_orig, 0);
+  if (args_info->temp_given)
+    write_into_file(outfile, "temp", args_info->temp_orig, 0);
+  if (args_info->interaction_length_given)
+    write_into_file(outfile, "interaction-length", args_info->interaction_length_orig, 0);
+  if (args_info->extension_cost_given)
+    write_into_file(outfile, "extension-cost", args_info->extension_cost_orig, 0);
+  if (args_info->probe_mode_given)
+    write_into_file(outfile, "probe-mode", 0, 0 );
+  if (args_info->probe_concentration_given)
+    write_into_file(outfile, "probe-concentration", args_info->probe_concentration_orig, 0);
+  if (args_info->na_concentration_given)
+    write_into_file(outfile, "na-concentration", args_info->na_concentration_orig, 0);
+  if (args_info->mg_concentration_given)
+    write_into_file(outfile, "mg-concentration", args_info->mg_concentration_orig, 0);
+  if (args_info->k_concentration_given)
+    write_into_file(outfile, "k-concentration", args_info->k_concentration_orig, 0);
+  if (args_info->tris_concentration_given)
+    write_into_file(outfile, "tris-concentration", args_info->tris_concentration_orig, 0);
+  if (args_info->fast_folding_given)
+    write_into_file(outfile, "fast-folding", args_info->fast_folding_orig, 0);
+  if (args_info->scale_accessibility_given)
+    write_into_file(outfile, "scale-accessibility", args_info->scale_accessibility_orig, 0);
+  if (args_info->constraint_given)
+    write_into_file(outfile, "constraint", 0, 0 );
+  if (args_info->alignment_mode_given)
+    write_into_file(outfile, "alignment-mode", 0, 0 );
+  if (args_info->convert_to_bin_given)
+    write_into_file(outfile, "convert-to-bin", 0, 0 );
+  if (args_info->duplex_distance_given)
+    write_into_file(outfile, "duplex-distance", args_info->duplex_distance_orig, 0);
+  if (args_info->energy_threshold_given)
+    write_into_file(outfile, "energy-threshold", args_info->energy_threshold_orig, 0);
+  if (args_info->produce_ps_given)
+    write_into_file(outfile, "produce-ps", args_info->produce_ps_orig, 0);
+  if (args_info->WindowLength_given)
+    write_into_file(outfile, "WindowLength", args_info->WindowLength_orig, 0);
+  
+
+  i = EXIT_SUCCESS;
+  return i;
+}
+
+int
+RNAplex_cmdline_parser_file_save(const char *filename, struct RNAplex_args_info *args_info)
+{
+  FILE *outfile;
+  int i = 0;
+
+  outfile = fopen(filename, "w");
+
+  if (!outfile)
+    {
+      fprintf (stderr, "%s: cannot open file for writing: %s\n", RNAPLEX_CMDLINE_PARSER_PACKAGE, filename);
+      return EXIT_FAILURE;
+    }
+
+  i = RNAplex_cmdline_parser_dump(outfile, args_info);
+  fclose (outfile);
+
+  return i;
+}
+
+void
+RNAplex_cmdline_parser_free (struct RNAplex_args_info *args_info)
+{
+  RNAplex_cmdline_parser_release (args_info);
+}
+
+/** @brief replacement of strdup, which is not standard */
+char *
+gengetopt_strdup (const char *s)
+{
+  char *result = 0;
+  if (!s)
+    return result;
+
+  result = (char*)malloc(strlen(s) + 1);
+  if (result == (char*)0)
+    return (char*)0;
+  strcpy(result, s);
+  return result;
+}
+
+int
+RNAplex_cmdline_parser (int argc, char **argv, struct RNAplex_args_info *args_info)
+{
+  return RNAplex_cmdline_parser2 (argc, argv, args_info, 0, 1, 1);
+}
+
+int
+RNAplex_cmdline_parser_ext (int argc, char **argv, struct RNAplex_args_info *args_info,
+                   struct RNAplex_cmdline_parser_params *params)
+{
+  int result;
+  result = RNAplex_cmdline_parser_internal (argc, argv, args_info, params, 0);
+
+  if (result == EXIT_FAILURE)
+    {
+      RNAplex_cmdline_parser_free (args_info);
+      exit (EXIT_FAILURE);
+    }
+  
+  return result;
+}
+
+int
+RNAplex_cmdline_parser2 (int argc, char **argv, struct RNAplex_args_info *args_info, int override, int initialize, int check_required)
+{
+  int result;
+  struct RNAplex_cmdline_parser_params params;
+  
+  params.override = override;
+  params.initialize = initialize;
+  params.check_required = check_required;
+  params.check_ambiguity = 0;
+  params.print_errors = 1;
+
+  result = RNAplex_cmdline_parser_internal (argc, argv, args_info, &params, 0);
+
+  if (result == EXIT_FAILURE)
+    {
+      RNAplex_cmdline_parser_free (args_info);
+      exit (EXIT_FAILURE);
+    }
+  
+  return result;
+}
+
+int
+RNAplex_cmdline_parser_required (struct RNAplex_args_info *args_info, const char *prog_name)
+{
+  FIX_UNUSED (args_info);
+  FIX_UNUSED (prog_name);
+  return EXIT_SUCCESS;
+}
+
+/*
+ * Extracted from the glibc source tree, version 2.3.6
+ *
+ * Licensed under the GPL as per the whole glibc source tree.
+ *
+ * This file was modified so that getopt_long can be called
+ * many times without risking previous memory to be spoiled.
+ *
+ * Modified by Andre Noll and Lorenzo Bettini for use in
+ * GNU gengetopt generated files.
+ *
+ */
+
+/* 
+ * we must include anything we need since this file is not thought to be
+ * inserted in a file already using getopt.h
+ *
+ * Lorenzo
+ */
+
+struct option
+{
+  const char *name;
+  /* has_arg can't be an enum because some compilers complain about
+     type mismatches in all the code that assumes it is an int.  */
+  int has_arg;
+  int *flag;
+  int val;
+};
+
+/* This version of `getopt' appears to the caller like standard Unix `getopt'
+   but it behaves differently for the user, since it allows the user
+   to intersperse the options with the other arguments.
+
+   As `getopt' works, it permutes the elements of ARGV so that,
+   when it is done, all the options precede everything else.  Thus
+   all application programs are extended to handle flexible argument order.
+*/
+/*
+   If the field `flag' is not NULL, it points to a variable that is set
+   to the value given in the field `val' when the option is found, but
+   left unchanged if the option is not found.
+
+   To have a long-named option do something other than set an `int' to
+   a compiled-in constant, such as set a value from `custom_optarg', set the
+   option's `flag' field to zero and its `val' field to a nonzero
+   value (the equivalent single-letter option character, if there is
+   one).  For long options that have a zero `flag' field, `getopt'
+   returns the contents of the `val' field.  */
+
+/* Names for the values of the `has_arg' field of `struct option'.  */
+#ifndef no_argument
+#define no_argument            0
+#endif
+
+#ifndef required_argument
+#define required_argument      1
+#endif
+
+#ifndef optional_argument
+#define optional_argument      2
+#endif
+
+struct custom_getopt_data {
+       /*
+        * These have exactly the same meaning as the corresponding global variables,
+        * except that they are used for the reentrant versions of getopt.
+        */
+       int custom_optind;
+       int custom_opterr;
+       int custom_optopt;
+       char *custom_optarg;
+
+       /* True if the internal members have been initialized.  */
+       int initialized;
+
+       /*
+        * The next char to be scanned in the option-element in which the last option
+        * character we returned was found.  This allows us to pick up the scan where
+        * we left off.  If this is zero, or a null string, it means resume the scan by
+        * advancing to the next ARGV-element.
+        */
+       char *nextchar;
+
+       /*
+        * Describe the part of ARGV that contains non-options that have been skipped.
+        * `first_nonopt' is the index in ARGV of the first of them; `last_nonopt' is
+        * the index after the last of them.
+        */
+       int first_nonopt;
+       int last_nonopt;
+};
+
+/*
+ * the variables optarg, optind, opterr and optopt are renamed with
+ * the custom_ prefix so that they don't interfere with getopt ones.
+ *
+ * Moreover they're static so they are visible only from within the
+ * file where this very file will be included.
+ */
+
+/*
+ * For communication from `custom_getopt' to the caller.  When `custom_getopt' finds an
+ * option that takes an argument, the argument value is returned here.
+ */
+static char *custom_optarg;
+
+/*
+ * Index in ARGV of the next element to be scanned.  This is used for
+ * communication to and from the caller and for communication between
+ * successive calls to `custom_getopt'.
+ *
+ * On entry to `custom_getopt', 1 means this is the first call; initialize.
+ *
+ * When `custom_getopt' returns -1, this is the index of the first of the non-option
+ * elements that the caller should itself scan.
+ *
+ * Otherwise, `custom_optind' communicates from one call to the next how much of ARGV
+ * has been scanned so far.
+ *
+ * 1003.2 says this must be 1 before any call.
+ */
+static int custom_optind = 1;
+
+/*
+ * Callers store zero here to inhibit the error message for unrecognized
+ * options.
+ */
+static int custom_opterr = 1;
+
+/*
+ * Set to an option character which was unrecognized.  This must be initialized
+ * on some systems to avoid linking in the system's own getopt implementation.
+ */
+static int custom_optopt = '?';
+
+/*
+ * Exchange two adjacent subsequences of ARGV.  One subsequence is elements
+ * [first_nonopt,last_nonopt) which contains all the non-options that have been
+ * skipped so far.  The other is elements [last_nonopt,custom_optind), which contains
+ * all the options processed since those non-options were skipped.
+ * `first_nonopt' and `last_nonopt' are relocated so that they describe the new
+ * indices of the non-options in ARGV after they are moved.
+ */
+static void exchange(char **argv, struct custom_getopt_data *d)
+{
+       int bottom = d->first_nonopt;
+       int middle = d->last_nonopt;
+       int top = d->custom_optind;
+       char *tem;
+
+       /*
+        * Exchange the shorter segment with the far end of the longer segment.
+        * That puts the shorter segment into the right place.  It leaves the
+        * longer segment in the right place overall, but it consists of two
+        * parts that need to be swapped next.
+        */
+       while (top > middle && middle > bottom) {
+               if (top - middle > middle - bottom) {
+                       /* Bottom segment is the short one.  */
+                       int len = middle - bottom;
+                       int i;
+
+                       /* Swap it with the top part of the top segment.  */
+                       for (i = 0; i < len; i++) {
+                               tem = argv[bottom + i];
+                               argv[bottom + i] =
+                                       argv[top - (middle - bottom) + i];
+                               argv[top - (middle - bottom) + i] = tem;
+                       }
+                       /* Exclude the moved bottom segment from further swapping.  */
+                       top -= len;
+               } else {
+                       /* Top segment is the short one.  */
+                       int len = top - middle;
+                       int i;
+
+                       /* Swap it with the bottom part of the bottom segment.  */
+                       for (i = 0; i < len; i++) {
+                               tem = argv[bottom + i];
+                               argv[bottom + i] = argv[middle + i];
+                               argv[middle + i] = tem;
+                       }
+                       /* Exclude the moved top segment from further swapping.  */
+                       bottom += len;
+               }
+       }
+       /* Update records for the slots the non-options now occupy.  */
+       d->first_nonopt += (d->custom_optind - d->last_nonopt);
+       d->last_nonopt = d->custom_optind;
+}
+
+/* Initialize the internal data when the first call is made.  */
+static void custom_getopt_initialize(struct custom_getopt_data *d)
+{
+       /*
+        * Start processing options with ARGV-element 1 (since ARGV-element 0
+        * is the program name); the sequence of previously skipped non-option
+        * ARGV-elements is empty.
+        */
+       d->first_nonopt = d->last_nonopt = d->custom_optind;
+       d->nextchar = NULL;
+       d->initialized = 1;
+}
+
+#define NONOPTION_P (argv[d->custom_optind][0] != '-' || argv[d->custom_optind][1] == '\0')
+
+/* return: zero: continue, nonzero: return given value to user */
+static int shuffle_argv(int argc, char *const *argv,const struct option *longopts,
+       struct custom_getopt_data *d)
+{
+       /*
+        * Give FIRST_NONOPT & LAST_NONOPT rational values if CUSTOM_OPTIND has been
+        * moved back by the user (who may also have changed the arguments).
+        */
+       if (d->last_nonopt > d->custom_optind)
+               d->last_nonopt = d->custom_optind;
+       if (d->first_nonopt > d->custom_optind)
+               d->first_nonopt = d->custom_optind;
+       /*
+        * If we have just processed some options following some
+        * non-options, exchange them so that the options come first.
+        */
+       if (d->first_nonopt != d->last_nonopt &&
+                       d->last_nonopt != d->custom_optind)
+               exchange((char **) argv, d);
+       else if (d->last_nonopt != d->custom_optind)
+               d->first_nonopt = d->custom_optind;
+       /*
+        * Skip any additional non-options and extend the range of
+        * non-options previously skipped.
+        */
+       while (d->custom_optind < argc && NONOPTION_P)
+               d->custom_optind++;
+       d->last_nonopt = d->custom_optind;
+       /*
+        * The special ARGV-element `--' means premature end of options.  Skip
+        * it like a null option, then exchange with previous non-options as if
+        * it were an option, then skip everything else like a non-option.
+        */
+       if (d->custom_optind != argc && !strcmp(argv[d->custom_optind], "--")) {
+               d->custom_optind++;
+               if (d->first_nonopt != d->last_nonopt
+                               && d->last_nonopt != d->custom_optind)
+                       exchange((char **) argv, d);
+               else if (d->first_nonopt == d->last_nonopt)
+                       d->first_nonopt = d->custom_optind;
+               d->last_nonopt = argc;
+               d->custom_optind = argc;
+       }
+       /*
+        * If we have done all the ARGV-elements, stop the scan and back over
+        * any non-options that we skipped and permuted.
+        */
+       if (d->custom_optind == argc) {
+               /*
+                * Set the next-arg-index to point at the non-options that we
+                * previously skipped, so the caller will digest them.
+                */
+               if (d->first_nonopt != d->last_nonopt)
+                       d->custom_optind = d->first_nonopt;
+               return -1;
+       }
+       /*
+        * If we have come to a non-option and did not permute it, either stop
+        * the scan or describe it to the caller and pass it by.
+        */
+       if (NONOPTION_P) {
+               d->custom_optarg = argv[d->custom_optind++];
+               return 1;
+       }
+       /*
+        * We have found another option-ARGV-element. Skip the initial
+        * punctuation.
+        */
+       d->nextchar = (argv[d->custom_optind] + 1 + (longopts != NULL && argv[d->custom_optind][1] == '-'));
+       return 0;
+}
+
+/*
+ * Check whether the ARGV-element is a long option.
+ *
+ * If there's a long option "fubar" and the ARGV-element is "-fu", consider
+ * that an abbreviation of the long option, just like "--fu", and not "-f" with
+ * arg "u".
+ *
+ * This distinction seems to be the most useful approach.
+ *
+ */
+static int check_long_opt(int argc, char *const *argv, const char *optstring,
+               const struct option *longopts, int *longind,
+               int print_errors, struct custom_getopt_data *d)
+{
+       char *nameend;
+       const struct option *p;
+       const struct option *pfound = NULL;
+       int exact = 0;
+       int ambig = 0;
+       int indfound = -1;
+       int option_index;
+
+       for (nameend = d->nextchar; *nameend && *nameend != '='; nameend++)
+               /* Do nothing.  */ ;
+
+       /* Test all long options for either exact match or abbreviated matches */
+       for (p = longopts, option_index = 0; p->name; p++, option_index++)
+               if (!strncmp(p->name, d->nextchar, nameend - d->nextchar)) {
+                       if ((unsigned int) (nameend - d->nextchar)
+                                       == (unsigned int) strlen(p->name)) {
+                               /* Exact match found.  */
+                               pfound = p;
+                               indfound = option_index;
+                               exact = 1;
+                               break;
+                       } else if (pfound == NULL) {
+                               /* First nonexact match found.  */
+                               pfound = p;
+                               indfound = option_index;
+                       } else if (pfound->has_arg != p->has_arg
+                                       || pfound->flag != p->flag
+                                       || pfound->val != p->val)
+                               /* Second or later nonexact match found.  */
+                               ambig = 1;
+               }
+       if (ambig && !exact) {
+               if (print_errors) {
+                       fprintf(stderr,
+                               "%s: option `%s' is ambiguous\n",
+                               argv[0], argv[d->custom_optind]);
+               }
+               d->nextchar += strlen(d->nextchar);
+               d->custom_optind++;
+               d->custom_optopt = 0;
+               return '?';
+       }
+       if (pfound) {
+               option_index = indfound;
+               d->custom_optind++;
+               if (*nameend) {
+                       if (pfound->has_arg != no_argument)
+                               d->custom_optarg = nameend + 1;
+                       else {
+                               if (print_errors) {
+                                       if (argv[d->custom_optind - 1][1] == '-') {
+                                               /* --option */
+                                               fprintf(stderr, "%s: option `--%s' doesn't allow an argument\n",
+                                                       argv[0], pfound->name);
+                                       } else {
+                                               /* +option or -option */
+                                               fprintf(stderr, "%s: option `%c%s' doesn't allow an argument\n",
+                                                       argv[0], argv[d->custom_optind - 1][0], pfound->name);
+                                       }
+
+                               }
+                               d->nextchar += strlen(d->nextchar);
+                               d->custom_optopt = pfound->val;
+                               return '?';
+                       }
+               } else if (pfound->has_arg == required_argument) {
+                       if (d->custom_optind < argc)
+                               d->custom_optarg = argv[d->custom_optind++];
+                       else {
+                               if (print_errors) {
+                                       fprintf(stderr,
+                                               "%s: option `%s' requires an argument\n",
+                                               argv[0],
+                                               argv[d->custom_optind - 1]);
+                               }
+                               d->nextchar += strlen(d->nextchar);
+                               d->custom_optopt = pfound->val;
+                               return optstring[0] == ':' ? ':' : '?';
+                       }
+               }
+               d->nextchar += strlen(d->nextchar);
+               if (longind != NULL)
+                       *longind = option_index;
+               if (pfound->flag) {
+                       *(pfound->flag) = pfound->val;
+                       return 0;
+               }
+               return pfound->val;
+       }
+       /*
+        * Can't find it as a long option.  If this is not getopt_long_only, or
+        * the option starts with '--' or is not a valid short option, then
+        * it's an error.  Otherwise interpret it as a short option.
+        */
+       if (print_errors) {
+               if (argv[d->custom_optind][1] == '-') {
+                       /* --option */
+                       fprintf(stderr,
+                               "%s: unrecognized option `--%s'\n",
+                               argv[0], d->nextchar);
+               } else {
+                       /* +option or -option */
+                       fprintf(stderr,
+                               "%s: unrecognized option `%c%s'\n",
+                               argv[0], argv[d->custom_optind][0],
+                               d->nextchar);
+               }
+       }
+       d->nextchar = (char *) "";
+       d->custom_optind++;
+       d->custom_optopt = 0;
+       return '?';
+}
+
+static int check_short_opt(int argc, char *const *argv, const char *optstring,
+               int print_errors, struct custom_getopt_data *d)
+{
+       char c = *d->nextchar++;
+       const char *temp = strchr(optstring, c);
+
+       /* Increment `custom_optind' when we start to process its last character.  */
+       if (*d->nextchar == '\0')
+               ++d->custom_optind;
+       if (!temp || c == ':') {
+               if (print_errors)
+                       fprintf(stderr, "%s: invalid option -- %c\n", argv[0], c);
+
+               d->custom_optopt = c;
+               return '?';
+       }
+       if (temp[1] == ':') {
+               if (temp[2] == ':') {
+                       /* This is an option that accepts an argument optionally.  */
+                       if (*d->nextchar != '\0') {
+                               d->custom_optarg = d->nextchar;
+                               d->custom_optind++;
+                       } else
+                               d->custom_optarg = NULL;
+                       d->nextchar = NULL;
+               } else {
+                       /* This is an option that requires an argument.  */
+                       if (*d->nextchar != '\0') {
+                               d->custom_optarg = d->nextchar;
+                               /*
+                                * If we end this ARGV-element by taking the
+                                * rest as an arg, we must advance to the next
+                                * element now.
+                                */
+                               d->custom_optind++;
+                       } else if (d->custom_optind == argc) {
+                               if (print_errors) {
+                                       fprintf(stderr,
+                                               "%s: option requires an argument -- %c\n",
+                                               argv[0], c);
+                               }
+                               d->custom_optopt = c;
+                               if (optstring[0] == ':')
+                                       c = ':';
+                               else
+                                       c = '?';
+                       } else
+                               /*
+                                * We already incremented `custom_optind' once;
+                                * increment it again when taking next ARGV-elt
+                                * as argument.
+                                */
+                               d->custom_optarg = argv[d->custom_optind++];
+                       d->nextchar = NULL;
+               }
+       }
+       return c;
+}
+
+/*
+ * Scan elements of ARGV for option characters given in OPTSTRING.
+ *
+ * If an element of ARGV starts with '-', and is not exactly "-" or "--",
+ * then it is an option element.  The characters of this element
+ * (aside from the initial '-') are option characters.  If `getopt'
+ * is called repeatedly, it returns successively each of the option characters
+ * from each of the option elements.
+ *
+ * If `getopt' finds another option character, it returns that character,
+ * updating `custom_optind' and `nextchar' so that the next call to `getopt' can
+ * resume the scan with the following option character or ARGV-element.
+ *
+ * If there are no more option characters, `getopt' returns -1.
+ * Then `custom_optind' is the index in ARGV of the first ARGV-element
+ * that is not an option.  (The ARGV-elements have been permuted
+ * so that those that are not options now come last.)
+ *
+ * OPTSTRING is a string containing the legitimate option characters.
+ * If an option character is seen that is not listed in OPTSTRING,
+ * return '?' after printing an error message.  If you set `custom_opterr' to
+ * zero, the error message is suppressed but we still return '?'.
+ *
+ * If a char in OPTSTRING is followed by a colon, that means it wants an arg,
+ * so the following text in the same ARGV-element, or the text of the following
+ * ARGV-element, is returned in `custom_optarg'.  Two colons mean an option that
+ * wants an optional arg; if there is text in the current ARGV-element,
+ * it is returned in `custom_optarg', otherwise `custom_optarg' is set to zero.
+ *
+ * If OPTSTRING starts with `-' or `+', it requests different methods of
+ * handling the non-option ARGV-elements.
+ * See the comments about RETURN_IN_ORDER and REQUIRE_ORDER, above.
+ *
+ * Long-named options begin with `--' instead of `-'.
+ * Their names may be abbreviated as long as the abbreviation is unique
+ * or is an exact match for some defined option.  If they have an
+ * argument, it follows the option name in the same ARGV-element, separated
+ * from the option name by a `=', or else the in next ARGV-element.
+ * When `getopt' finds a long-named option, it returns 0 if that option's
+ * `flag' field is nonzero, the value of the option's `val' field
+ * if the `flag' field is zero.
+ *
+ * The elements of ARGV aren't really const, because we permute them.
+ * But we pretend they're const in the prototype to be compatible
+ * with other systems.
+ *
+ * LONGOPTS is a vector of `struct option' terminated by an
+ * element containing a name which is zero.
+ *
+ * LONGIND returns the index in LONGOPT of the long-named option found.
+ * It is only valid when a long-named option has been found by the most
+ * recent call.
+ *
+ * Return the option character from OPTS just read.  Return -1 when there are
+ * no more options.  For unrecognized options, or options missing arguments,
+ * `custom_optopt' is set to the option letter, and '?' is returned.
+ *
+ * The OPTS string is a list of characters which are recognized option letters,
+ * optionally followed by colons, specifying that that letter takes an
+ * argument, to be placed in `custom_optarg'.
+ *
+ * If a letter in OPTS is followed by two colons, its argument is optional.
+ * This behavior is specific to the GNU `getopt'.
+ *
+ * The argument `--' causes premature termination of argument scanning,
+ * explicitly telling `getopt' that there are no more options.  If OPTS begins
+ * with `--', then non-option arguments are treated as arguments to the option
+ * '\0'.  This behavior is specific to the GNU `getopt'.
+ */
+
+static int getopt_internal_r(int argc, char *const *argv, const char *optstring,
+               const struct option *longopts, int *longind,
+               struct custom_getopt_data *d)
+{
+       int ret, print_errors = d->custom_opterr;
+
+       if (optstring[0] == ':')
+               print_errors = 0;
+       if (argc < 1)
+               return -1;
+       d->custom_optarg = NULL;
+
+       /* 
+        * This is a big difference with GNU getopt, since optind == 0
+        * means initialization while here 1 means first call.
+        */
+       if (d->custom_optind == 0 || !d->initialized) {
+               if (d->custom_optind == 0)
+                       d->custom_optind = 1;   /* Don't scan ARGV[0], the program name.  */
+               custom_getopt_initialize(d);
+       }
+       if (d->nextchar == NULL || *d->nextchar == '\0') {
+               ret = shuffle_argv(argc, argv, longopts, d);
+               if (ret)
+                       return ret;
+       }
+       if (longopts && (argv[d->custom_optind][1] == '-' ))
+               return check_long_opt(argc, argv, optstring, longopts,
+                       longind, print_errors, d);
+       return check_short_opt(argc, argv, optstring, print_errors, d);
+}
+
+static int custom_getopt_internal(int argc, char *const *argv, const char *optstring,
+       const struct option *longopts, int *longind)
+{
+       int result;
+       /* Keep a global copy of all internal members of d */
+       static struct custom_getopt_data d;
+
+       d.custom_optind = custom_optind;
+       d.custom_opterr = custom_opterr;
+       result = getopt_internal_r(argc, argv, optstring, longopts,
+               longind, &d);
+       custom_optind = d.custom_optind;
+       custom_optarg = d.custom_optarg;
+       custom_optopt = d.custom_optopt;
+       return result;
+}
+
+static int custom_getopt_long (int argc, char *const *argv, const char *options,
+       const struct option *long_options, int *opt_index)
+{
+       return custom_getopt_internal(argc, argv, options, long_options,
+               opt_index);
+}
+
+
+static char *package_name = 0;
+
+/**
+ * @brief updates an option
+ * @param field the generic pointer to the field to update
+ * @param orig_field the pointer to the orig field
+ * @param field_given the pointer to the number of occurrence of this option
+ * @param prev_given the pointer to the number of occurrence already seen
+ * @param value the argument for this option (if null no arg was specified)
+ * @param possible_values the possible values for this option (if specified)
+ * @param default_value the default value (in case the option only accepts fixed values)
+ * @param arg_type the type of this option
+ * @param check_ambiguity @see RNAplex_cmdline_parser_params.check_ambiguity
+ * @param override @see RNAplex_cmdline_parser_params.override
+ * @param no_free whether to free a possible previous value
+ * @param multiple_option whether this is a multiple option
+ * @param long_opt the corresponding long option
+ * @param short_opt the corresponding short option (or '-' if none)
+ * @param additional_error possible further error specification
+ */
+static
+int update_arg(void *field, char **orig_field,
+               unsigned int *field_given, unsigned int *prev_given, 
+               char *value, const char *possible_values[],
+               const char *default_value,
+               RNAplex_cmdline_parser_arg_type arg_type,
+               int check_ambiguity, int override,
+               int no_free, int multiple_option,
+               const char *long_opt, char short_opt,
+               const char *additional_error)
+{
+  char *stop_char = 0;
+  const char *val = value;
+  int found;
+  char **string_field;
+  FIX_UNUSED (field);
+
+  stop_char = 0;
+  found = 0;
+
+  if (!multiple_option && prev_given && (*prev_given || (check_ambiguity && *field_given)))
+    {
+      if (short_opt != '-')
+        fprintf (stderr, "%s: `--%s' (`-%c') option given more than once%s\n", 
+               package_name, long_opt, short_opt,
+               (additional_error ? additional_error : ""));
+      else
+        fprintf (stderr, "%s: `--%s' option given more than once%s\n", 
+               package_name, long_opt,
+               (additional_error ? additional_error : ""));
+      return 1; /* failure */
+    }
+
+  FIX_UNUSED (default_value);
+    
+  if (field_given && *field_given && ! override)
+    return 0;
+  if (prev_given)
+    (*prev_given)++;
+  if (field_given)
+    (*field_given)++;
+  if (possible_values)
+    val = possible_values[found];
+
+  switch(arg_type) {
+  case ARG_FLAG:
+    *((int *)field) = !*((int *)field);
+    break;
+  case ARG_INT:
+    if (val) *((int *)field) = strtol (val, &stop_char, 0);
+    break;
+  case ARG_DOUBLE:
+    if (val) *((double *)field) = strtod (val, &stop_char);
+    break;
+  case ARG_STRING:
+    if (val) {
+      string_field = (char **)field;
+      if (!no_free && *string_field)
+        free (*string_field); /* free previous string */
+      *string_field = gengetopt_strdup (val);
+    }
+    break;
+  default:
+    break;
+  };
+
+  /* check numeric conversion */
+  switch(arg_type) {
+  case ARG_INT:
+  case ARG_DOUBLE:
+    if (val && !(stop_char && *stop_char == '\0')) {
+      fprintf(stderr, "%s: invalid numeric value: %s\n", package_name, val);
+      return 1; /* failure */
+    }
+    break;
+  default:
+    ;
+  };
+
+  /* store the original value */
+  switch(arg_type) {
+  case ARG_NO:
+  case ARG_FLAG:
+    break;
+  default:
+    if (value && orig_field) {
+      if (no_free) {
+        *orig_field = value;
+      } else {
+        if (*orig_field)
+          free (*orig_field); /* free previous string */
+        *orig_field = gengetopt_strdup (value);
+      }
+    }
+  };
+
+  return 0; /* OK */
+}
+
+
+int
+RNAplex_cmdline_parser_internal (
+  int argc, char **argv, struct RNAplex_args_info *args_info,
+                        struct RNAplex_cmdline_parser_params *params, const char *additional_error)
+{
+  int c;       /* Character of the parsed option.  */
+
+  int error = 0;
+  struct RNAplex_args_info local_args_info;
+  
+  int override;
+  int initialize;
+  int check_required;
+  int check_ambiguity;
+
+  char *optarg;
+  int optind;
+  int opterr;
+  int optopt;
+  
+  package_name = argv[0];
+  
+  override = params->override;
+  initialize = params->initialize;
+  check_required = params->check_required;
+  check_ambiguity = params->check_ambiguity;
+
+  if (initialize)
+    RNAplex_cmdline_parser_init (args_info);
+
+  RNAplex_cmdline_parser_init (&local_args_info);
+
+  optarg = 0;
+  optind = 0;
+  opterr = params->print_errors;
+  optopt = '?';
+
+  while (1)
+    {
+      int option_index = 0;
+
+      static struct option long_options[] = {
+        { "help",      0, NULL, 'h' },
+        { "detailed-help",     0, NULL, 0 },
+        { "version",   0, NULL, 0 },
+        { "query",     1, NULL, 'q' },
+        { "target",    1, NULL, 't' },
+        { "accessibility-dir", 1, NULL, 'a' },
+        { "binary",    0, NULL, 'b' },
+        { "paramFile", 1, NULL, 'P' },
+        { "temp",      1, NULL, 'T' },
+        { "interaction-length",        1, NULL, 'l' },
+        { "extension-cost",    1, NULL, 'c' },
+        { "probe-mode",        0, NULL, 'p' },
+        { "probe-concentration",       1, NULL, 'Q' },
+        { "na-concentration",  1, NULL, 'N' },
+        { "mg-concentration",  1, NULL, 'M' },
+        { "k-concentration",   1, NULL, 'K' },
+        { "tris-concentration",        1, NULL, 'U' },
+        { "fast-folding",      1, NULL, 'f' },
+        { "scale-accessibility",       1, NULL, 'V' },
+        { "constraint",        0, NULL, 'C' },
+        { "alignment-mode",    0, NULL, 'A' },
+        { "convert-to-bin",    0, NULL, 'k' },
+        { "duplex-distance",   1, NULL, 'z' },
+        { "energy-threshold",  1, NULL, 'e' },
+        { "produce-ps",        1, NULL, 'I' },
+        { "WindowLength",      1, NULL, 'L' },
+        { 0,  0, 0, 0 }
+      };
+
+      custom_optarg = optarg;
+      custom_optind = optind;
+      custom_opterr = opterr;
+      custom_optopt = optopt;
+
+      c = custom_getopt_long (argc, argv, "hq:t:a:bP:T:l:c:pQ:N:M:K:U:f:V:CAkz:e:I:L:", long_options, &option_index);
+
+      optarg = custom_optarg;
+      optind = custom_optind;
+      opterr = custom_opterr;
+      optopt = custom_optopt;
+
+      if (c == -1) break;      /* Exit from `while (1)' loop.  */
+
+      switch (c)
+        {
+        case 'h':      /* Print help and exit.  */
+          RNAplex_cmdline_parser_print_help ();
+          RNAplex_cmdline_parser_free (&local_args_info);
+          exit (EXIT_SUCCESS);
+
+        case 'q':      /* File containing the query sequence.
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->query_arg), 
+               &(args_info->query_orig), &(args_info->query_given),
+              &(local_args_info.query_given), optarg, 0, 0, ARG_STRING,
+              check_ambiguity, override, 0, 0,
+              "query", 'q',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 't':      /* File containing the target sequence.
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->target_arg), 
+               &(args_info->target_orig), &(args_info->target_given),
+              &(local_args_info.target_given), optarg, 0, 0, ARG_STRING,
+              check_ambiguity, override, 0, 0,
+              "target", 't',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'a':      /* Location of the accessibility profiles.
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->accessibility_dir_arg), 
+               &(args_info->accessibility_dir_orig), &(args_info->accessibility_dir_given),
+              &(local_args_info.accessibility_dir_given), optarg, 0, 0, ARG_STRING,
+              check_ambiguity, override, 0, 0,
+              "accessibility-dir", 'a',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'b':      /* Allow the reading and parsing of memory dumped opening energy file
+.  */
+        
+        
+          if (update_arg((void *)&(args_info->binary_flag), 0, &(args_info->binary_given),
+              &(local_args_info.binary_given), optarg, 0, 0, ARG_FLAG,
+              check_ambiguity, override, 1, 0, "binary", 'b',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'P':      /* Read energy parameters from paramfile, instead of using the default parameter set.
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->paramFile_arg), 
+               &(args_info->paramFile_orig), &(args_info->paramFile_given),
+              &(local_args_info.paramFile_given), optarg, 0, 0, ARG_STRING,
+              check_ambiguity, override, 0, 0,
+              "paramFile", 'P',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'T':      /* Rescale energy parameters to a temperature T. Default is 37C.
+        
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->temp_arg), 
+               &(args_info->temp_orig), &(args_info->temp_given),
+              &(local_args_info.temp_given), optarg, 0, 0, ARG_DOUBLE,
+              check_ambiguity, override, 0, 0,
+              "temp", 'T',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'l':      /* Maximal length of an interaction
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->interaction_length_arg), 
+               &(args_info->interaction_length_orig), &(args_info->interaction_length_given),
+              &(local_args_info.interaction_length_given), optarg, 0, "40", ARG_INT,
+              check_ambiguity, override, 0, 0,
+              "interaction-length", 'l',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'c':      /* Cost to add to each nucleotide in a duplex
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->extension_cost_arg), 
+               &(args_info->extension_cost_orig), &(args_info->extension_cost_given),
+              &(local_args_info.extension_cost_given), optarg, 0, "0", ARG_INT,
+              check_ambiguity, override, 0, 0,
+              "extension-cost", 'c',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'p':      /* Compute Tm for probes.  */
+        
+        
+          if (update_arg((void *)&(args_info->probe_mode_flag), 0, &(args_info->probe_mode_given),
+              &(local_args_info.probe_mode_given), optarg, 0, 0, ARG_FLAG,
+              check_ambiguity, override, 1, 0, "probe-mode", 'p',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'Q':      /* Set the probe concentration for the Tm computation
+        
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->probe_concentration_arg), 
+               &(args_info->probe_concentration_orig), &(args_info->probe_concentration_given),
+              &(local_args_info.probe_concentration_given), optarg, 0, "0.1", ARG_DOUBLE,
+              check_ambiguity, override, 0, 0,
+              "probe-concentration", 'Q',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'N':      /* Set the Na+ concentration for the Tm computation
+        
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->na_concentration_arg), 
+               &(args_info->na_concentration_orig), &(args_info->na_concentration_given),
+              &(local_args_info.na_concentration_given), optarg, 0, "1.0", ARG_DOUBLE,
+              check_ambiguity, override, 0, 0,
+              "na-concentration", 'N',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'M':      /* Set the Mg2+ concentration for the Tm computation
+        
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->mg_concentration_arg), 
+               &(args_info->mg_concentration_orig), &(args_info->mg_concentration_given),
+              &(local_args_info.mg_concentration_given), optarg, 0, "1.0", ARG_DOUBLE,
+              check_ambiguity, override, 0, 0,
+              "mg-concentration", 'M',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'K':      /* Set the K+ concentration for the Tm computation
+        
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->k_concentration_arg), 
+               &(args_info->k_concentration_orig), &(args_info->k_concentration_given),
+              &(local_args_info.k_concentration_given), optarg, 0, "1.0", ARG_DOUBLE,
+              check_ambiguity, override, 0, 0,
+              "k-concentration", 'K',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'U':      /* Set the tris+ concentration for the Tm computation
+        
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->tris_concentration_arg), 
+               &(args_info->tris_concentration_orig), &(args_info->tris_concentration_given),
+              &(local_args_info.tris_concentration_given), optarg, 0, "1.0", ARG_DOUBLE,
+              check_ambiguity, override, 0, 0,
+              "tris-concentration", 'U',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'f':      /* Speedup of the target search
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->fast_folding_arg), 
+               &(args_info->fast_folding_orig), &(args_info->fast_folding_given),
+              &(local_args_info.fast_folding_given), optarg, 0, "0", ARG_INT,
+              check_ambiguity, override, 0, 0,
+              "fast-folding", 'f',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'V':      /* Rescale all opening energy by a factor V
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->scale_accessibility_arg), 
+               &(args_info->scale_accessibility_orig), &(args_info->scale_accessibility_given),
+              &(local_args_info.scale_accessibility_given), optarg, 0, "1.0", ARG_DOUBLE,
+              check_ambiguity, override, 0, 0,
+              "scale-accessibility", 'V',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'C':      /* Calculate structures subject to constraints.
+.  */
+        
+        
+          if (update_arg((void *)&(args_info->constraint_flag), 0, &(args_info->constraint_given),
+              &(local_args_info.constraint_given), optarg, 0, 0, ARG_FLAG,
+              check_ambiguity, override, 1, 0, "constraint", 'C',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'A':      /* Tells RNAplex to compute interactions based on alignments
+.  */
+        
+        
+          if (update_arg((void *)&(args_info->alignment_mode_flag), 0, &(args_info->alignment_mode_given),
+              &(local_args_info.alignment_mode_given), optarg, 0, 0, ARG_FLAG,
+              check_ambiguity, override, 1, 0, "alignment-mode", 'A',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'k':      /* If set, RNAplex will convert all opening energy file in a directory set by the -a option into binary opening energy files
+.  */
+        
+        
+          if (update_arg((void *)&(args_info->convert_to_bin_flag), 0, &(args_info->convert_to_bin_given),
+              &(local_args_info.convert_to_bin_given), optarg, 0, 0, ARG_FLAG,
+              check_ambiguity, override, 1, 0, "convert-to-bin", 'k',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'z':      /* Distance between target 3' ends of two consecutive duplexes
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->duplex_distance_arg), 
+               &(args_info->duplex_distance_orig), &(args_info->duplex_distance_given),
+              &(local_args_info.duplex_distance_given), optarg, 0, "0", ARG_INT,
+              check_ambiguity, override, 0, 0,
+              "duplex-distance", 'z',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'e':      /* Minimal energy for a duplex to be returned
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->energy_threshold_arg), 
+               &(args_info->energy_threshold_orig), &(args_info->energy_threshold_given),
+              &(local_args_info.energy_threshold_given), optarg, 0, "-100000", ARG_DOUBLE,
+              check_ambiguity, override, 0, 0,
+              "energy-threshold", 'e',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'I':      /* Draw an alignment annotated interaction from RNAplex
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->produce_ps_arg), 
+               &(args_info->produce_ps_orig), &(args_info->produce_ps_given),
+              &(local_args_info.produce_ps_given), optarg, 0, 0, ARG_STRING,
+              check_ambiguity, override, 0, 0,
+              "produce-ps", 'I',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'L':      /* Tells how large the region around the target site should be for redrawing the alignment interaction
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->WindowLength_arg), 
+               &(args_info->WindowLength_orig), &(args_info->WindowLength_given),
+              &(local_args_info.WindowLength_given), optarg, 0, "1", ARG_INT,
+              check_ambiguity, override, 0, 0,
+              "WindowLength", 'L',
+              additional_error))
+            goto failure;
+        
+          break;
+
+        case 0:        /* Long option with no short option */
+          if (strcmp (long_options[option_index].name, "detailed-help") == 0) {
+            RNAplex_cmdline_parser_print_detailed_help ();
+            RNAplex_cmdline_parser_free (&local_args_info);
+            exit (EXIT_SUCCESS);
+          }
+
+          if (strcmp (long_options[option_index].name, "version") == 0) {
+            RNAplex_cmdline_parser_print_version ();
+            RNAplex_cmdline_parser_free (&local_args_info);
+            exit (EXIT_SUCCESS);
+          }
+
+        case '?':      /* Invalid option.  */
+          /* `getopt_long' already printed an error message.  */
+          goto failure;
+
+        default:       /* bug: option not considered.  */
+          fprintf (stderr, "%s: option unknown: %c%s\n", RNAPLEX_CMDLINE_PARSER_PACKAGE, c, (additional_error ? additional_error : ""));
+          abort ();
+        } /* switch */
+    } /* while */
+
+
+
+
+  RNAplex_cmdline_parser_release (&local_args_info);
+
+  if ( error )
+    return (EXIT_FAILURE);
+
+  return 0;
+
+failure:
+  
+  RNAplex_cmdline_parser_release (&local_args_info);
+  return (EXIT_FAILURE);
+}