WSTester updated to work plus hopefully all the other changes that need to go into...
[jabaws.git] / binaries / src / ViennaRNA / Progs / RNAinverse_cmdl.c
diff --git a/binaries/src/ViennaRNA/Progs/RNAinverse_cmdl.c b/binaries/src/ViennaRNA/Progs/RNAinverse_cmdl.c
new file mode 100644 (file)
index 0000000..0e92751
--- /dev/null
@@ -0,0 +1,1513 @@
+/*
+  File autogenerated by gengetopt version 2.22.5
+  generated with the following command:
+  gengetopt -i RNAinverse.ggo --file-name=RNAinverse_cmdl --include-getopt --default-optional --func-name=RNAinverse_cmdline_parser --arg-struct-name=RNAinverse_args_info
+
+  The developers of gengetopt consider the fixed text that goes in all
+  gengetopt output files to be in the public domain:
+  we make no copyright claims on it.
+*/
+
+/* If we use autoconf.  */
+#ifdef HAVE_CONFIG_H
+#include "config.h"
+#endif
+
+#include <stdio.h>
+#include <stdlib.h>
+#include <string.h>
+
+#ifndef FIX_UNUSED
+#define FIX_UNUSED(X) (void) (X) /* avoid warnings for unused params */
+#endif
+
+
+#include "RNAinverse_cmdl.h"
+
+const char *RNAinverse_args_info_purpose = "Find RNA sequences with given secondary structure";
+
+const char *RNAinverse_args_info_usage = "Usage: RNAinverse [OPTIONS]...";
+
+const char *RNAinverse_args_info_description = "The program searches for sequences folding into a predefined structure, thereby \ninverting the folding algorithm. Target structures (in bracket notation) and \nstarting sequences for the search are read alternately from stdin.\nCharacters in the start sequence other than \"AUGC\" (or the alphabet specified \nwith -a) will be treated as wild cards and replaced by a random character. Any \nlower case characters in the start sequence will be kept fixed during the \nsearch. If necessary, the sequence will be elongated to the length of the \nstructure. Thus a string of \"N\"s as well as a blank line specify a random \nstart sequence.\nFor each search the best sequence found and its Hamming distance to the start \nsequence are printed to stdout. If the the search was unsuccessful, a structure \ndistance to the target is appended.\nThe -Fp and -R options can modify the output format, see commandline options \nbelow.\nThe program will continue to read new structures and sequences until a line \nconsisting of the single character \"@\" or an end of file condition is \nencountered.\n";
+
+const char *RNAinverse_args_info_detailed_help[] = {
+  "  -h, --help                 Print help and exit",
+  "      --detailed-help        Print help, including all details and hidden \n                               options, and exit",
+  "      --full-help            Print help, including hidden options, and exit",
+  "  -V, --version              Print version and exit",
+  "\nGeneral Options:",
+  "  Below are command line options which alter the general behavior of this \n  program\n",
+  "  -R, --repeat[=INT]         Search repeatedly for the same structure.\n                               If an argument is supplied to this option it \n                               must follow the option flag immediately. E.g.: \n                               -R5\n                                 (default=`100')",
+  "  If repeats is negative search until --repeats exact solutions are found, no \n  output is done for unsuccessful searches. Be aware, that the program will not \n  terminate if the target structure can not be found.\n  If no value is supplied with this option, the default value is used.\n\n",
+  "  -a, --alphabet=ALPHABET    Find sequences using only nucleotides from a given \n                               alphabet.\n\n",
+  "  -v, --verbose              In conjunction with a negative value supplied to \n                               -R, print the last subsequence and substructure \n                               for each unsuccessful search.\n\n                                 (default=off)",
+  "\nAlgorithms:",
+  "  Select additional algorithms which should be included in the calculations.\n\n",
+  "  -F, --function=mp          Use minimum energy (-Fm), partition function \n                               folding (-Fp) or both (-Fmp).\n                                 (default=`m')",
+  "  In partition function mode, the probability of the target structure \n  exp(-E(S)/kT)/Q is maximized. This probability is written in brackets after \n  the found sequence and Hamming distance. In most cases you'll want to use the \n  -f option in conjunction with -Fp, see below.\n\n",
+  "  -f, --final=FLOAT          In combination with -Fp stop search when sequence \n                               is found with E(s)-F is smaller than final, \n                               where F=-kT*ln(Q).\n\n",
+  "\nModel Details:",
+  "  -T, --temp=DOUBLE          Rescale energy parameters to a temperature of temp \n                               C. Default is 37C.\n\n",
+  "  -4, --noTetra              Do not include special tabulated stabilizing \n                               energies for tri-, tetra- and hexaloop hairpins. \n                               Mostly for testing.\n\n                                 (default=off)",
+  "  -d, --dangles=INT          How to treat \"dangling end\" energies for bases \n                               adjacent to helices in free ends and multi-loops\n                                 (default=`2')",
+  "  \n  With -d1 only unpaired bases can participate in at most one dangling end, \n  this is unsupported for the partition function folding.\n\n  With -d2 this check is ignored, dangling energies will be added for the bases \n  adjacent to a helix on both sides in any case; this is the default for \n  partition function folding (-p).\n  The option -d0 ignores dangling ends altogether (mostly for debugging).\n  With -d3 mfe folding will allow coaxial stacking of adjacent helices in \n  multi-loops. At the moment the implementation will not allow coaxial stacking \n  of the two interior pairs in a loop of degree 3 and works only for mfe \n  folding.\n\n  Note that by default (as well as with -d1 and -d3) pf and mfe folding treat \n  dangling ends differently. Use -d2 in addition to -Fp to ensure that both \n  algorithms use the same energy model.\n\n",
+  "      --noGU                 Do not allow GU pairs\n\n                                 (default=off)",
+  "      --noClosingGU          Do not allow GU pairs at the end of helices\n\n                                 (default=off)",
+  "  -P, --paramFile=paramfile  Read energy parameters from paramfile, instead of \n                               using the default parameter set.\n",
+  "  A sample parameter file should accompany your distribution.\n  See the RNAlib documentation for details on the file format.\n\n",
+  "      --nsp=STRING           Allow other pairs in addition to the usual \n                               AU,GC,and GU pairs.\n",
+  "  Its argument is a comma separated list of additionally allowed pairs. If the \n  first character is a \"-\" then AB will imply that AB and BA are allowed \n  pairs.\n  e.g. RNAfold -nsp -GA  will allow GA and AG pairs. Nonstandard pairs are \n  given 0 stacking energy.\n\n",
+  "  -e, --energyModel=INT      Rarely used option to fold sequences from the \n                               artificial ABCD... alphabet, where A pairs B, \n                               C-D etc.  Use the energy parameters for GC (-e \n                               1) or AU (-e 2) pairs.\n\n",
+  "\nIf in doubt our program is right, nature is at fault.\nComments should be sent to rna@tbi.univie.ac.at.\n",
+    0
+};
+static void
+init_full_help_array(void)
+{
+  RNAinverse_args_info_full_help[0] = RNAinverse_args_info_detailed_help[0];
+  RNAinverse_args_info_full_help[1] = RNAinverse_args_info_detailed_help[1];
+  RNAinverse_args_info_full_help[2] = RNAinverse_args_info_detailed_help[2];
+  RNAinverse_args_info_full_help[3] = RNAinverse_args_info_detailed_help[3];
+  RNAinverse_args_info_full_help[4] = RNAinverse_args_info_detailed_help[4];
+  RNAinverse_args_info_full_help[5] = RNAinverse_args_info_detailed_help[5];
+  RNAinverse_args_info_full_help[6] = RNAinverse_args_info_detailed_help[6];
+  RNAinverse_args_info_full_help[7] = RNAinverse_args_info_detailed_help[8];
+  RNAinverse_args_info_full_help[8] = RNAinverse_args_info_detailed_help[9];
+  RNAinverse_args_info_full_help[9] = RNAinverse_args_info_detailed_help[10];
+  RNAinverse_args_info_full_help[10] = RNAinverse_args_info_detailed_help[11];
+  RNAinverse_args_info_full_help[11] = RNAinverse_args_info_detailed_help[12];
+  RNAinverse_args_info_full_help[12] = RNAinverse_args_info_detailed_help[14];
+  RNAinverse_args_info_full_help[13] = RNAinverse_args_info_detailed_help[15];
+  RNAinverse_args_info_full_help[14] = RNAinverse_args_info_detailed_help[16];
+  RNAinverse_args_info_full_help[15] = RNAinverse_args_info_detailed_help[17];
+  RNAinverse_args_info_full_help[16] = RNAinverse_args_info_detailed_help[18];
+  RNAinverse_args_info_full_help[17] = RNAinverse_args_info_detailed_help[20];
+  RNAinverse_args_info_full_help[18] = RNAinverse_args_info_detailed_help[21];
+  RNAinverse_args_info_full_help[19] = RNAinverse_args_info_detailed_help[22];
+  RNAinverse_args_info_full_help[20] = RNAinverse_args_info_detailed_help[24];
+  RNAinverse_args_info_full_help[21] = RNAinverse_args_info_detailed_help[26];
+  RNAinverse_args_info_full_help[22] = RNAinverse_args_info_detailed_help[27];
+  RNAinverse_args_info_full_help[23] = 0; 
+  
+}
+
+const char *RNAinverse_args_info_full_help[24];
+
+static void
+init_help_array(void)
+{
+  RNAinverse_args_info_help[0] = RNAinverse_args_info_detailed_help[0];
+  RNAinverse_args_info_help[1] = RNAinverse_args_info_detailed_help[1];
+  RNAinverse_args_info_help[2] = RNAinverse_args_info_detailed_help[2];
+  RNAinverse_args_info_help[3] = RNAinverse_args_info_detailed_help[3];
+  RNAinverse_args_info_help[4] = RNAinverse_args_info_detailed_help[4];
+  RNAinverse_args_info_help[5] = RNAinverse_args_info_detailed_help[5];
+  RNAinverse_args_info_help[6] = RNAinverse_args_info_detailed_help[6];
+  RNAinverse_args_info_help[7] = RNAinverse_args_info_detailed_help[8];
+  RNAinverse_args_info_help[8] = RNAinverse_args_info_detailed_help[9];
+  RNAinverse_args_info_help[9] = RNAinverse_args_info_detailed_help[10];
+  RNAinverse_args_info_help[10] = RNAinverse_args_info_detailed_help[11];
+  RNAinverse_args_info_help[11] = RNAinverse_args_info_detailed_help[12];
+  RNAinverse_args_info_help[12] = RNAinverse_args_info_detailed_help[14];
+  RNAinverse_args_info_help[13] = RNAinverse_args_info_detailed_help[15];
+  RNAinverse_args_info_help[14] = RNAinverse_args_info_detailed_help[16];
+  RNAinverse_args_info_help[15] = RNAinverse_args_info_detailed_help[17];
+  RNAinverse_args_info_help[16] = RNAinverse_args_info_detailed_help[18];
+  RNAinverse_args_info_help[17] = RNAinverse_args_info_detailed_help[20];
+  RNAinverse_args_info_help[18] = RNAinverse_args_info_detailed_help[21];
+  RNAinverse_args_info_help[19] = RNAinverse_args_info_detailed_help[22];
+  RNAinverse_args_info_help[20] = RNAinverse_args_info_detailed_help[27];
+  RNAinverse_args_info_help[21] = 0; 
+  
+}
+
+const char *RNAinverse_args_info_help[22];
+
+typedef enum {ARG_NO
+  , ARG_FLAG
+  , ARG_STRING
+  , ARG_INT
+  , ARG_FLOAT
+  , ARG_DOUBLE
+} RNAinverse_cmdline_parser_arg_type;
+
+static
+void clear_given (struct RNAinverse_args_info *args_info);
+static
+void clear_args (struct RNAinverse_args_info *args_info);
+
+static int
+RNAinverse_cmdline_parser_internal (int argc, char **argv, struct RNAinverse_args_info *args_info,
+                        struct RNAinverse_cmdline_parser_params *params, const char *additional_error);
+
+
+static char *
+gengetopt_strdup (const char *s);
+
+static
+void clear_given (struct RNAinverse_args_info *args_info)
+{
+  args_info->help_given = 0 ;
+  args_info->detailed_help_given = 0 ;
+  args_info->full_help_given = 0 ;
+  args_info->version_given = 0 ;
+  args_info->repeat_given = 0 ;
+  args_info->alphabet_given = 0 ;
+  args_info->verbose_given = 0 ;
+  args_info->function_given = 0 ;
+  args_info->final_given = 0 ;
+  args_info->temp_given = 0 ;
+  args_info->noTetra_given = 0 ;
+  args_info->dangles_given = 0 ;
+  args_info->noGU_given = 0 ;
+  args_info->noClosingGU_given = 0 ;
+  args_info->paramFile_given = 0 ;
+  args_info->nsp_given = 0 ;
+  args_info->energyModel_given = 0 ;
+}
+
+static
+void clear_args (struct RNAinverse_args_info *args_info)
+{
+  FIX_UNUSED (args_info);
+  args_info->repeat_arg = 100;
+  args_info->repeat_orig = NULL;
+  args_info->alphabet_arg = NULL;
+  args_info->alphabet_orig = NULL;
+  args_info->verbose_flag = 0;
+  args_info->function_arg = gengetopt_strdup ("m");
+  args_info->function_orig = NULL;
+  args_info->final_orig = NULL;
+  args_info->temp_orig = NULL;
+  args_info->noTetra_flag = 0;
+  args_info->dangles_arg = 2;
+  args_info->dangles_orig = NULL;
+  args_info->noGU_flag = 0;
+  args_info->noClosingGU_flag = 0;
+  args_info->paramFile_arg = NULL;
+  args_info->paramFile_orig = NULL;
+  args_info->nsp_arg = NULL;
+  args_info->nsp_orig = NULL;
+  args_info->energyModel_orig = NULL;
+  
+}
+
+static
+void init_args_info(struct RNAinverse_args_info *args_info)
+{
+  init_full_help_array(); 
+  init_help_array(); 
+  args_info->help_help = RNAinverse_args_info_detailed_help[0] ;
+  args_info->detailed_help_help = RNAinverse_args_info_detailed_help[1] ;
+  args_info->full_help_help = RNAinverse_args_info_detailed_help[2] ;
+  args_info->version_help = RNAinverse_args_info_detailed_help[3] ;
+  args_info->repeat_help = RNAinverse_args_info_detailed_help[6] ;
+  args_info->alphabet_help = RNAinverse_args_info_detailed_help[8] ;
+  args_info->verbose_help = RNAinverse_args_info_detailed_help[9] ;
+  args_info->function_help = RNAinverse_args_info_detailed_help[12] ;
+  args_info->final_help = RNAinverse_args_info_detailed_help[14] ;
+  args_info->temp_help = RNAinverse_args_info_detailed_help[16] ;
+  args_info->noTetra_help = RNAinverse_args_info_detailed_help[17] ;
+  args_info->dangles_help = RNAinverse_args_info_detailed_help[18] ;
+  args_info->noGU_help = RNAinverse_args_info_detailed_help[20] ;
+  args_info->noClosingGU_help = RNAinverse_args_info_detailed_help[21] ;
+  args_info->paramFile_help = RNAinverse_args_info_detailed_help[22] ;
+  args_info->nsp_help = RNAinverse_args_info_detailed_help[24] ;
+  args_info->energyModel_help = RNAinverse_args_info_detailed_help[26] ;
+  
+}
+
+void
+RNAinverse_cmdline_parser_print_version (void)
+{
+  printf ("%s %s\n",
+     (strlen(RNAINVERSE_CMDLINE_PARSER_PACKAGE_NAME) ? RNAINVERSE_CMDLINE_PARSER_PACKAGE_NAME : RNAINVERSE_CMDLINE_PARSER_PACKAGE),
+     RNAINVERSE_CMDLINE_PARSER_VERSION);
+}
+
+static void print_help_common(void) {
+  RNAinverse_cmdline_parser_print_version ();
+
+  if (strlen(RNAinverse_args_info_purpose) > 0)
+    printf("\n%s\n", RNAinverse_args_info_purpose);
+
+  if (strlen(RNAinverse_args_info_usage) > 0)
+    printf("\n%s\n", RNAinverse_args_info_usage);
+
+  printf("\n");
+
+  if (strlen(RNAinverse_args_info_description) > 0)
+    printf("%s\n\n", RNAinverse_args_info_description);
+}
+
+void
+RNAinverse_cmdline_parser_print_help (void)
+{
+  int i = 0;
+  print_help_common();
+  while (RNAinverse_args_info_help[i])
+    printf("%s\n", RNAinverse_args_info_help[i++]);
+}
+
+void
+RNAinverse_cmdline_parser_print_full_help (void)
+{
+  int i = 0;
+  print_help_common();
+  while (RNAinverse_args_info_full_help[i])
+    printf("%s\n", RNAinverse_args_info_full_help[i++]);
+}
+
+void
+RNAinverse_cmdline_parser_print_detailed_help (void)
+{
+  int i = 0;
+  print_help_common();
+  while (RNAinverse_args_info_detailed_help[i])
+    printf("%s\n", RNAinverse_args_info_detailed_help[i++]);
+}
+
+void
+RNAinverse_cmdline_parser_init (struct RNAinverse_args_info *args_info)
+{
+  clear_given (args_info);
+  clear_args (args_info);
+  init_args_info (args_info);
+}
+
+void
+RNAinverse_cmdline_parser_params_init(struct RNAinverse_cmdline_parser_params *params)
+{
+  if (params)
+    { 
+      params->override = 0;
+      params->initialize = 1;
+      params->check_required = 1;
+      params->check_ambiguity = 0;
+      params->print_errors = 1;
+    }
+}
+
+struct RNAinverse_cmdline_parser_params *
+RNAinverse_cmdline_parser_params_create(void)
+{
+  struct RNAinverse_cmdline_parser_params *params = 
+    (struct RNAinverse_cmdline_parser_params *)malloc(sizeof(struct RNAinverse_cmdline_parser_params));
+  RNAinverse_cmdline_parser_params_init(params);  
+  return params;
+}
+
+static void
+free_string_field (char **s)
+{
+  if (*s)
+    {
+      free (*s);
+      *s = 0;
+    }
+}
+
+
+static void
+RNAinverse_cmdline_parser_release (struct RNAinverse_args_info *args_info)
+{
+
+  free_string_field (&(args_info->repeat_orig));
+  free_string_field (&(args_info->alphabet_arg));
+  free_string_field (&(args_info->alphabet_orig));
+  free_string_field (&(args_info->function_arg));
+  free_string_field (&(args_info->function_orig));
+  free_string_field (&(args_info->final_orig));
+  free_string_field (&(args_info->temp_orig));
+  free_string_field (&(args_info->dangles_orig));
+  free_string_field (&(args_info->paramFile_arg));
+  free_string_field (&(args_info->paramFile_orig));
+  free_string_field (&(args_info->nsp_arg));
+  free_string_field (&(args_info->nsp_orig));
+  free_string_field (&(args_info->energyModel_orig));
+  
+  
+
+  clear_given (args_info);
+}
+
+
+static void
+write_into_file(FILE *outfile, const char *opt, const char *arg, const char *values[])
+{
+  FIX_UNUSED (values);
+  if (arg) {
+    fprintf(outfile, "%s=\"%s\"\n", opt, arg);
+  } else {
+    fprintf(outfile, "%s\n", opt);
+  }
+}
+
+
+int
+RNAinverse_cmdline_parser_dump(FILE *outfile, struct RNAinverse_args_info *args_info)
+{
+  int i = 0;
+
+  if (!outfile)
+    {
+      fprintf (stderr, "%s: cannot dump options to stream\n", RNAINVERSE_CMDLINE_PARSER_PACKAGE);
+      return EXIT_FAILURE;
+    }
+
+  if (args_info->help_given)
+    write_into_file(outfile, "help", 0, 0 );
+  if (args_info->detailed_help_given)
+    write_into_file(outfile, "detailed-help", 0, 0 );
+  if (args_info->full_help_given)
+    write_into_file(outfile, "full-help", 0, 0 );
+  if (args_info->version_given)
+    write_into_file(outfile, "version", 0, 0 );
+  if (args_info->repeat_given)
+    write_into_file(outfile, "repeat", args_info->repeat_orig, 0);
+  if (args_info->alphabet_given)
+    write_into_file(outfile, "alphabet", args_info->alphabet_orig, 0);
+  if (args_info->verbose_given)
+    write_into_file(outfile, "verbose", 0, 0 );
+  if (args_info->function_given)
+    write_into_file(outfile, "function", args_info->function_orig, 0);
+  if (args_info->final_given)
+    write_into_file(outfile, "final", args_info->final_orig, 0);
+  if (args_info->temp_given)
+    write_into_file(outfile, "temp", args_info->temp_orig, 0);
+  if (args_info->noTetra_given)
+    write_into_file(outfile, "noTetra", 0, 0 );
+  if (args_info->dangles_given)
+    write_into_file(outfile, "dangles", args_info->dangles_orig, 0);
+  if (args_info->noGU_given)
+    write_into_file(outfile, "noGU", 0, 0 );
+  if (args_info->noClosingGU_given)
+    write_into_file(outfile, "noClosingGU", 0, 0 );
+  if (args_info->paramFile_given)
+    write_into_file(outfile, "paramFile", args_info->paramFile_orig, 0);
+  if (args_info->nsp_given)
+    write_into_file(outfile, "nsp", args_info->nsp_orig, 0);
+  if (args_info->energyModel_given)
+    write_into_file(outfile, "energyModel", args_info->energyModel_orig, 0);
+  
+
+  i = EXIT_SUCCESS;
+  return i;
+}
+
+int
+RNAinverse_cmdline_parser_file_save(const char *filename, struct RNAinverse_args_info *args_info)
+{
+  FILE *outfile;
+  int i = 0;
+
+  outfile = fopen(filename, "w");
+
+  if (!outfile)
+    {
+      fprintf (stderr, "%s: cannot open file for writing: %s\n", RNAINVERSE_CMDLINE_PARSER_PACKAGE, filename);
+      return EXIT_FAILURE;
+    }
+
+  i = RNAinverse_cmdline_parser_dump(outfile, args_info);
+  fclose (outfile);
+
+  return i;
+}
+
+void
+RNAinverse_cmdline_parser_free (struct RNAinverse_args_info *args_info)
+{
+  RNAinverse_cmdline_parser_release (args_info);
+}
+
+/** @brief replacement of strdup, which is not standard */
+char *
+gengetopt_strdup (const char *s)
+{
+  char *result = 0;
+  if (!s)
+    return result;
+
+  result = (char*)malloc(strlen(s) + 1);
+  if (result == (char*)0)
+    return (char*)0;
+  strcpy(result, s);
+  return result;
+}
+
+int
+RNAinverse_cmdline_parser (int argc, char **argv, struct RNAinverse_args_info *args_info)
+{
+  return RNAinverse_cmdline_parser2 (argc, argv, args_info, 0, 1, 1);
+}
+
+int
+RNAinverse_cmdline_parser_ext (int argc, char **argv, struct RNAinverse_args_info *args_info,
+                   struct RNAinverse_cmdline_parser_params *params)
+{
+  int result;
+  result = RNAinverse_cmdline_parser_internal (argc, argv, args_info, params, 0);
+
+  if (result == EXIT_FAILURE)
+    {
+      RNAinverse_cmdline_parser_free (args_info);
+      exit (EXIT_FAILURE);
+    }
+  
+  return result;
+}
+
+int
+RNAinverse_cmdline_parser2 (int argc, char **argv, struct RNAinverse_args_info *args_info, int override, int initialize, int check_required)
+{
+  int result;
+  struct RNAinverse_cmdline_parser_params params;
+  
+  params.override = override;
+  params.initialize = initialize;
+  params.check_required = check_required;
+  params.check_ambiguity = 0;
+  params.print_errors = 1;
+
+  result = RNAinverse_cmdline_parser_internal (argc, argv, args_info, &params, 0);
+
+  if (result == EXIT_FAILURE)
+    {
+      RNAinverse_cmdline_parser_free (args_info);
+      exit (EXIT_FAILURE);
+    }
+  
+  return result;
+}
+
+int
+RNAinverse_cmdline_parser_required (struct RNAinverse_args_info *args_info, const char *prog_name)
+{
+  FIX_UNUSED (args_info);
+  FIX_UNUSED (prog_name);
+  return EXIT_SUCCESS;
+}
+
+/*
+ * Extracted from the glibc source tree, version 2.3.6
+ *
+ * Licensed under the GPL as per the whole glibc source tree.
+ *
+ * This file was modified so that getopt_long can be called
+ * many times without risking previous memory to be spoiled.
+ *
+ * Modified by Andre Noll and Lorenzo Bettini for use in
+ * GNU gengetopt generated files.
+ *
+ */
+
+/* 
+ * we must include anything we need since this file is not thought to be
+ * inserted in a file already using getopt.h
+ *
+ * Lorenzo
+ */
+
+struct option
+{
+  const char *name;
+  /* has_arg can't be an enum because some compilers complain about
+     type mismatches in all the code that assumes it is an int.  */
+  int has_arg;
+  int *flag;
+  int val;
+};
+
+/* This version of `getopt' appears to the caller like standard Unix `getopt'
+   but it behaves differently for the user, since it allows the user
+   to intersperse the options with the other arguments.
+
+   As `getopt' works, it permutes the elements of ARGV so that,
+   when it is done, all the options precede everything else.  Thus
+   all application programs are extended to handle flexible argument order.
+*/
+/*
+   If the field `flag' is not NULL, it points to a variable that is set
+   to the value given in the field `val' when the option is found, but
+   left unchanged if the option is not found.
+
+   To have a long-named option do something other than set an `int' to
+   a compiled-in constant, such as set a value from `custom_optarg', set the
+   option's `flag' field to zero and its `val' field to a nonzero
+   value (the equivalent single-letter option character, if there is
+   one).  For long options that have a zero `flag' field, `getopt'
+   returns the contents of the `val' field.  */
+
+/* Names for the values of the `has_arg' field of `struct option'.  */
+#ifndef no_argument
+#define no_argument            0
+#endif
+
+#ifndef required_argument
+#define required_argument      1
+#endif
+
+#ifndef optional_argument
+#define optional_argument      2
+#endif
+
+struct custom_getopt_data {
+       /*
+        * These have exactly the same meaning as the corresponding global variables,
+        * except that they are used for the reentrant versions of getopt.
+        */
+       int custom_optind;
+       int custom_opterr;
+       int custom_optopt;
+       char *custom_optarg;
+
+       /* True if the internal members have been initialized.  */
+       int initialized;
+
+       /*
+        * The next char to be scanned in the option-element in which the last option
+        * character we returned was found.  This allows us to pick up the scan where
+        * we left off.  If this is zero, or a null string, it means resume the scan by
+        * advancing to the next ARGV-element.
+        */
+       char *nextchar;
+
+       /*
+        * Describe the part of ARGV that contains non-options that have been skipped.
+        * `first_nonopt' is the index in ARGV of the first of them; `last_nonopt' is
+        * the index after the last of them.
+        */
+       int first_nonopt;
+       int last_nonopt;
+};
+
+/*
+ * the variables optarg, optind, opterr and optopt are renamed with
+ * the custom_ prefix so that they don't interfere with getopt ones.
+ *
+ * Moreover they're static so they are visible only from within the
+ * file where this very file will be included.
+ */
+
+/*
+ * For communication from `custom_getopt' to the caller.  When `custom_getopt' finds an
+ * option that takes an argument, the argument value is returned here.
+ */
+static char *custom_optarg;
+
+/*
+ * Index in ARGV of the next element to be scanned.  This is used for
+ * communication to and from the caller and for communication between
+ * successive calls to `custom_getopt'.
+ *
+ * On entry to `custom_getopt', 1 means this is the first call; initialize.
+ *
+ * When `custom_getopt' returns -1, this is the index of the first of the non-option
+ * elements that the caller should itself scan.
+ *
+ * Otherwise, `custom_optind' communicates from one call to the next how much of ARGV
+ * has been scanned so far.
+ *
+ * 1003.2 says this must be 1 before any call.
+ */
+static int custom_optind = 1;
+
+/*
+ * Callers store zero here to inhibit the error message for unrecognized
+ * options.
+ */
+static int custom_opterr = 1;
+
+/*
+ * Set to an option character which was unrecognized.  This must be initialized
+ * on some systems to avoid linking in the system's own getopt implementation.
+ */
+static int custom_optopt = '?';
+
+/*
+ * Exchange two adjacent subsequences of ARGV.  One subsequence is elements
+ * [first_nonopt,last_nonopt) which contains all the non-options that have been
+ * skipped so far.  The other is elements [last_nonopt,custom_optind), which contains
+ * all the options processed since those non-options were skipped.
+ * `first_nonopt' and `last_nonopt' are relocated so that they describe the new
+ * indices of the non-options in ARGV after they are moved.
+ */
+static void exchange(char **argv, struct custom_getopt_data *d)
+{
+       int bottom = d->first_nonopt;
+       int middle = d->last_nonopt;
+       int top = d->custom_optind;
+       char *tem;
+
+       /*
+        * Exchange the shorter segment with the far end of the longer segment.
+        * That puts the shorter segment into the right place.  It leaves the
+        * longer segment in the right place overall, but it consists of two
+        * parts that need to be swapped next.
+        */
+       while (top > middle && middle > bottom) {
+               if (top - middle > middle - bottom) {
+                       /* Bottom segment is the short one.  */
+                       int len = middle - bottom;
+                       int i;
+
+                       /* Swap it with the top part of the top segment.  */
+                       for (i = 0; i < len; i++) {
+                               tem = argv[bottom + i];
+                               argv[bottom + i] =
+                                       argv[top - (middle - bottom) + i];
+                               argv[top - (middle - bottom) + i] = tem;
+                       }
+                       /* Exclude the moved bottom segment from further swapping.  */
+                       top -= len;
+               } else {
+                       /* Top segment is the short one.  */
+                       int len = top - middle;
+                       int i;
+
+                       /* Swap it with the bottom part of the bottom segment.  */
+                       for (i = 0; i < len; i++) {
+                               tem = argv[bottom + i];
+                               argv[bottom + i] = argv[middle + i];
+                               argv[middle + i] = tem;
+                       }
+                       /* Exclude the moved top segment from further swapping.  */
+                       bottom += len;
+               }
+       }
+       /* Update records for the slots the non-options now occupy.  */
+       d->first_nonopt += (d->custom_optind - d->last_nonopt);
+       d->last_nonopt = d->custom_optind;
+}
+
+/* Initialize the internal data when the first call is made.  */
+static void custom_getopt_initialize(struct custom_getopt_data *d)
+{
+       /*
+        * Start processing options with ARGV-element 1 (since ARGV-element 0
+        * is the program name); the sequence of previously skipped non-option
+        * ARGV-elements is empty.
+        */
+       d->first_nonopt = d->last_nonopt = d->custom_optind;
+       d->nextchar = NULL;
+       d->initialized = 1;
+}
+
+#define NONOPTION_P (argv[d->custom_optind][0] != '-' || argv[d->custom_optind][1] == '\0')
+
+/* return: zero: continue, nonzero: return given value to user */
+static int shuffle_argv(int argc, char *const *argv,const struct option *longopts,
+       struct custom_getopt_data *d)
+{
+       /*
+        * Give FIRST_NONOPT & LAST_NONOPT rational values if CUSTOM_OPTIND has been
+        * moved back by the user (who may also have changed the arguments).
+        */
+       if (d->last_nonopt > d->custom_optind)
+               d->last_nonopt = d->custom_optind;
+       if (d->first_nonopt > d->custom_optind)
+               d->first_nonopt = d->custom_optind;
+       /*
+        * If we have just processed some options following some
+        * non-options, exchange them so that the options come first.
+        */
+       if (d->first_nonopt != d->last_nonopt &&
+                       d->last_nonopt != d->custom_optind)
+               exchange((char **) argv, d);
+       else if (d->last_nonopt != d->custom_optind)
+               d->first_nonopt = d->custom_optind;
+       /*
+        * Skip any additional non-options and extend the range of
+        * non-options previously skipped.
+        */
+       while (d->custom_optind < argc && NONOPTION_P)
+               d->custom_optind++;
+       d->last_nonopt = d->custom_optind;
+       /*
+        * The special ARGV-element `--' means premature end of options.  Skip
+        * it like a null option, then exchange with previous non-options as if
+        * it were an option, then skip everything else like a non-option.
+        */
+       if (d->custom_optind != argc && !strcmp(argv[d->custom_optind], "--")) {
+               d->custom_optind++;
+               if (d->first_nonopt != d->last_nonopt
+                               && d->last_nonopt != d->custom_optind)
+                       exchange((char **) argv, d);
+               else if (d->first_nonopt == d->last_nonopt)
+                       d->first_nonopt = d->custom_optind;
+               d->last_nonopt = argc;
+               d->custom_optind = argc;
+       }
+       /*
+        * If we have done all the ARGV-elements, stop the scan and back over
+        * any non-options that we skipped and permuted.
+        */
+       if (d->custom_optind == argc) {
+               /*
+                * Set the next-arg-index to point at the non-options that we
+                * previously skipped, so the caller will digest them.
+                */
+               if (d->first_nonopt != d->last_nonopt)
+                       d->custom_optind = d->first_nonopt;
+               return -1;
+       }
+       /*
+        * If we have come to a non-option and did not permute it, either stop
+        * the scan or describe it to the caller and pass it by.
+        */
+       if (NONOPTION_P) {
+               d->custom_optarg = argv[d->custom_optind++];
+               return 1;
+       }
+       /*
+        * We have found another option-ARGV-element. Skip the initial
+        * punctuation.
+        */
+       d->nextchar = (argv[d->custom_optind] + 1 + (longopts != NULL && argv[d->custom_optind][1] == '-'));
+       return 0;
+}
+
+/*
+ * Check whether the ARGV-element is a long option.
+ *
+ * If there's a long option "fubar" and the ARGV-element is "-fu", consider
+ * that an abbreviation of the long option, just like "--fu", and not "-f" with
+ * arg "u".
+ *
+ * This distinction seems to be the most useful approach.
+ *
+ */
+static int check_long_opt(int argc, char *const *argv, const char *optstring,
+               const struct option *longopts, int *longind,
+               int print_errors, struct custom_getopt_data *d)
+{
+       char *nameend;
+       const struct option *p;
+       const struct option *pfound = NULL;
+       int exact = 0;
+       int ambig = 0;
+       int indfound = -1;
+       int option_index;
+
+       for (nameend = d->nextchar; *nameend && *nameend != '='; nameend++)
+               /* Do nothing.  */ ;
+
+       /* Test all long options for either exact match or abbreviated matches */
+       for (p = longopts, option_index = 0; p->name; p++, option_index++)
+               if (!strncmp(p->name, d->nextchar, nameend - d->nextchar)) {
+                       if ((unsigned int) (nameend - d->nextchar)
+                                       == (unsigned int) strlen(p->name)) {
+                               /* Exact match found.  */
+                               pfound = p;
+                               indfound = option_index;
+                               exact = 1;
+                               break;
+                       } else if (pfound == NULL) {
+                               /* First nonexact match found.  */
+                               pfound = p;
+                               indfound = option_index;
+                       } else if (pfound->has_arg != p->has_arg
+                                       || pfound->flag != p->flag
+                                       || pfound->val != p->val)
+                               /* Second or later nonexact match found.  */
+                               ambig = 1;
+               }
+       if (ambig && !exact) {
+               if (print_errors) {
+                       fprintf(stderr,
+                               "%s: option `%s' is ambiguous\n",
+                               argv[0], argv[d->custom_optind]);
+               }
+               d->nextchar += strlen(d->nextchar);
+               d->custom_optind++;
+               d->custom_optopt = 0;
+               return '?';
+       }
+       if (pfound) {
+               option_index = indfound;
+               d->custom_optind++;
+               if (*nameend) {
+                       if (pfound->has_arg != no_argument)
+                               d->custom_optarg = nameend + 1;
+                       else {
+                               if (print_errors) {
+                                       if (argv[d->custom_optind - 1][1] == '-') {
+                                               /* --option */
+                                               fprintf(stderr, "%s: option `--%s' doesn't allow an argument\n",
+                                                       argv[0], pfound->name);
+                                       } else {
+                                               /* +option or -option */
+                                               fprintf(stderr, "%s: option `%c%s' doesn't allow an argument\n",
+                                                       argv[0], argv[d->custom_optind - 1][0], pfound->name);
+                                       }
+
+                               }
+                               d->nextchar += strlen(d->nextchar);
+                               d->custom_optopt = pfound->val;
+                               return '?';
+                       }
+               } else if (pfound->has_arg == required_argument) {
+                       if (d->custom_optind < argc)
+                               d->custom_optarg = argv[d->custom_optind++];
+                       else {
+                               if (print_errors) {
+                                       fprintf(stderr,
+                                               "%s: option `%s' requires an argument\n",
+                                               argv[0],
+                                               argv[d->custom_optind - 1]);
+                               }
+                               d->nextchar += strlen(d->nextchar);
+                               d->custom_optopt = pfound->val;
+                               return optstring[0] == ':' ? ':' : '?';
+                       }
+               }
+               d->nextchar += strlen(d->nextchar);
+               if (longind != NULL)
+                       *longind = option_index;
+               if (pfound->flag) {
+                       *(pfound->flag) = pfound->val;
+                       return 0;
+               }
+               return pfound->val;
+       }
+       /*
+        * Can't find it as a long option.  If this is not getopt_long_only, or
+        * the option starts with '--' or is not a valid short option, then
+        * it's an error.  Otherwise interpret it as a short option.
+        */
+       if (print_errors) {
+               if (argv[d->custom_optind][1] == '-') {
+                       /* --option */
+                       fprintf(stderr,
+                               "%s: unrecognized option `--%s'\n",
+                               argv[0], d->nextchar);
+               } else {
+                       /* +option or -option */
+                       fprintf(stderr,
+                               "%s: unrecognized option `%c%s'\n",
+                               argv[0], argv[d->custom_optind][0],
+                               d->nextchar);
+               }
+       }
+       d->nextchar = (char *) "";
+       d->custom_optind++;
+       d->custom_optopt = 0;
+       return '?';
+}
+
+static int check_short_opt(int argc, char *const *argv, const char *optstring,
+               int print_errors, struct custom_getopt_data *d)
+{
+       char c = *d->nextchar++;
+       const char *temp = strchr(optstring, c);
+
+       /* Increment `custom_optind' when we start to process its last character.  */
+       if (*d->nextchar == '\0')
+               ++d->custom_optind;
+       if (!temp || c == ':') {
+               if (print_errors)
+                       fprintf(stderr, "%s: invalid option -- %c\n", argv[0], c);
+
+               d->custom_optopt = c;
+               return '?';
+       }
+       if (temp[1] == ':') {
+               if (temp[2] == ':') {
+                       /* This is an option that accepts an argument optionally.  */
+                       if (*d->nextchar != '\0') {
+                               d->custom_optarg = d->nextchar;
+                               d->custom_optind++;
+                       } else
+                               d->custom_optarg = NULL;
+                       d->nextchar = NULL;
+               } else {
+                       /* This is an option that requires an argument.  */
+                       if (*d->nextchar != '\0') {
+                               d->custom_optarg = d->nextchar;
+                               /*
+                                * If we end this ARGV-element by taking the
+                                * rest as an arg, we must advance to the next
+                                * element now.
+                                */
+                               d->custom_optind++;
+                       } else if (d->custom_optind == argc) {
+                               if (print_errors) {
+                                       fprintf(stderr,
+                                               "%s: option requires an argument -- %c\n",
+                                               argv[0], c);
+                               }
+                               d->custom_optopt = c;
+                               if (optstring[0] == ':')
+                                       c = ':';
+                               else
+                                       c = '?';
+                       } else
+                               /*
+                                * We already incremented `custom_optind' once;
+                                * increment it again when taking next ARGV-elt
+                                * as argument.
+                                */
+                               d->custom_optarg = argv[d->custom_optind++];
+                       d->nextchar = NULL;
+               }
+       }
+       return c;
+}
+
+/*
+ * Scan elements of ARGV for option characters given in OPTSTRING.
+ *
+ * If an element of ARGV starts with '-', and is not exactly "-" or "--",
+ * then it is an option element.  The characters of this element
+ * (aside from the initial '-') are option characters.  If `getopt'
+ * is called repeatedly, it returns successively each of the option characters
+ * from each of the option elements.
+ *
+ * If `getopt' finds another option character, it returns that character,
+ * updating `custom_optind' and `nextchar' so that the next call to `getopt' can
+ * resume the scan with the following option character or ARGV-element.
+ *
+ * If there are no more option characters, `getopt' returns -1.
+ * Then `custom_optind' is the index in ARGV of the first ARGV-element
+ * that is not an option.  (The ARGV-elements have been permuted
+ * so that those that are not options now come last.)
+ *
+ * OPTSTRING is a string containing the legitimate option characters.
+ * If an option character is seen that is not listed in OPTSTRING,
+ * return '?' after printing an error message.  If you set `custom_opterr' to
+ * zero, the error message is suppressed but we still return '?'.
+ *
+ * If a char in OPTSTRING is followed by a colon, that means it wants an arg,
+ * so the following text in the same ARGV-element, or the text of the following
+ * ARGV-element, is returned in `custom_optarg'.  Two colons mean an option that
+ * wants an optional arg; if there is text in the current ARGV-element,
+ * it is returned in `custom_optarg', otherwise `custom_optarg' is set to zero.
+ *
+ * If OPTSTRING starts with `-' or `+', it requests different methods of
+ * handling the non-option ARGV-elements.
+ * See the comments about RETURN_IN_ORDER and REQUIRE_ORDER, above.
+ *
+ * Long-named options begin with `--' instead of `-'.
+ * Their names may be abbreviated as long as the abbreviation is unique
+ * or is an exact match for some defined option.  If they have an
+ * argument, it follows the option name in the same ARGV-element, separated
+ * from the option name by a `=', or else the in next ARGV-element.
+ * When `getopt' finds a long-named option, it returns 0 if that option's
+ * `flag' field is nonzero, the value of the option's `val' field
+ * if the `flag' field is zero.
+ *
+ * The elements of ARGV aren't really const, because we permute them.
+ * But we pretend they're const in the prototype to be compatible
+ * with other systems.
+ *
+ * LONGOPTS is a vector of `struct option' terminated by an
+ * element containing a name which is zero.
+ *
+ * LONGIND returns the index in LONGOPT of the long-named option found.
+ * It is only valid when a long-named option has been found by the most
+ * recent call.
+ *
+ * Return the option character from OPTS just read.  Return -1 when there are
+ * no more options.  For unrecognized options, or options missing arguments,
+ * `custom_optopt' is set to the option letter, and '?' is returned.
+ *
+ * The OPTS string is a list of characters which are recognized option letters,
+ * optionally followed by colons, specifying that that letter takes an
+ * argument, to be placed in `custom_optarg'.
+ *
+ * If a letter in OPTS is followed by two colons, its argument is optional.
+ * This behavior is specific to the GNU `getopt'.
+ *
+ * The argument `--' causes premature termination of argument scanning,
+ * explicitly telling `getopt' that there are no more options.  If OPTS begins
+ * with `--', then non-option arguments are treated as arguments to the option
+ * '\0'.  This behavior is specific to the GNU `getopt'.
+ */
+
+static int getopt_internal_r(int argc, char *const *argv, const char *optstring,
+               const struct option *longopts, int *longind,
+               struct custom_getopt_data *d)
+{
+       int ret, print_errors = d->custom_opterr;
+
+       if (optstring[0] == ':')
+               print_errors = 0;
+       if (argc < 1)
+               return -1;
+       d->custom_optarg = NULL;
+
+       /* 
+        * This is a big difference with GNU getopt, since optind == 0
+        * means initialization while here 1 means first call.
+        */
+       if (d->custom_optind == 0 || !d->initialized) {
+               if (d->custom_optind == 0)
+                       d->custom_optind = 1;   /* Don't scan ARGV[0], the program name.  */
+               custom_getopt_initialize(d);
+       }
+       if (d->nextchar == NULL || *d->nextchar == '\0') {
+               ret = shuffle_argv(argc, argv, longopts, d);
+               if (ret)
+                       return ret;
+       }
+       if (longopts && (argv[d->custom_optind][1] == '-' ))
+               return check_long_opt(argc, argv, optstring, longopts,
+                       longind, print_errors, d);
+       return check_short_opt(argc, argv, optstring, print_errors, d);
+}
+
+static int custom_getopt_internal(int argc, char *const *argv, const char *optstring,
+       const struct option *longopts, int *longind)
+{
+       int result;
+       /* Keep a global copy of all internal members of d */
+       static struct custom_getopt_data d;
+
+       d.custom_optind = custom_optind;
+       d.custom_opterr = custom_opterr;
+       result = getopt_internal_r(argc, argv, optstring, longopts,
+               longind, &d);
+       custom_optind = d.custom_optind;
+       custom_optarg = d.custom_optarg;
+       custom_optopt = d.custom_optopt;
+       return result;
+}
+
+static int custom_getopt_long (int argc, char *const *argv, const char *options,
+       const struct option *long_options, int *opt_index)
+{
+       return custom_getopt_internal(argc, argv, options, long_options,
+               opt_index);
+}
+
+
+static char *package_name = 0;
+
+/**
+ * @brief updates an option
+ * @param field the generic pointer to the field to update
+ * @param orig_field the pointer to the orig field
+ * @param field_given the pointer to the number of occurrence of this option
+ * @param prev_given the pointer to the number of occurrence already seen
+ * @param value the argument for this option (if null no arg was specified)
+ * @param possible_values the possible values for this option (if specified)
+ * @param default_value the default value (in case the option only accepts fixed values)
+ * @param arg_type the type of this option
+ * @param check_ambiguity @see RNAinverse_cmdline_parser_params.check_ambiguity
+ * @param override @see RNAinverse_cmdline_parser_params.override
+ * @param no_free whether to free a possible previous value
+ * @param multiple_option whether this is a multiple option
+ * @param long_opt the corresponding long option
+ * @param short_opt the corresponding short option (or '-' if none)
+ * @param additional_error possible further error specification
+ */
+static
+int update_arg(void *field, char **orig_field,
+               unsigned int *field_given, unsigned int *prev_given, 
+               char *value, const char *possible_values[],
+               const char *default_value,
+               RNAinverse_cmdline_parser_arg_type arg_type,
+               int check_ambiguity, int override,
+               int no_free, int multiple_option,
+               const char *long_opt, char short_opt,
+               const char *additional_error)
+{
+  char *stop_char = 0;
+  const char *val = value;
+  int found;
+  char **string_field;
+  FIX_UNUSED (field);
+
+  stop_char = 0;
+  found = 0;
+
+  if (!multiple_option && prev_given && (*prev_given || (check_ambiguity && *field_given)))
+    {
+      if (short_opt != '-')
+        fprintf (stderr, "%s: `--%s' (`-%c') option given more than once%s\n", 
+               package_name, long_opt, short_opt,
+               (additional_error ? additional_error : ""));
+      else
+        fprintf (stderr, "%s: `--%s' option given more than once%s\n", 
+               package_name, long_opt,
+               (additional_error ? additional_error : ""));
+      return 1; /* failure */
+    }
+
+  FIX_UNUSED (default_value);
+    
+  if (field_given && *field_given && ! override)
+    return 0;
+  if (prev_given)
+    (*prev_given)++;
+  if (field_given)
+    (*field_given)++;
+  if (possible_values)
+    val = possible_values[found];
+
+  switch(arg_type) {
+  case ARG_FLAG:
+    *((int *)field) = !*((int *)field);
+    break;
+  case ARG_INT:
+    if (val) *((int *)field) = strtol (val, &stop_char, 0);
+    break;
+  case ARG_FLOAT:
+    if (val) *((float *)field) = (float)strtod (val, &stop_char);
+    break;
+  case ARG_DOUBLE:
+    if (val) *((double *)field) = strtod (val, &stop_char);
+    break;
+  case ARG_STRING:
+    if (val) {
+      string_field = (char **)field;
+      if (!no_free && *string_field)
+        free (*string_field); /* free previous string */
+      *string_field = gengetopt_strdup (val);
+    }
+    break;
+  default:
+    break;
+  };
+
+  /* check numeric conversion */
+  switch(arg_type) {
+  case ARG_INT:
+  case ARG_FLOAT:
+  case ARG_DOUBLE:
+    if (val && !(stop_char && *stop_char == '\0')) {
+      fprintf(stderr, "%s: invalid numeric value: %s\n", package_name, val);
+      return 1; /* failure */
+    }
+    break;
+  default:
+    ;
+  };
+
+  /* store the original value */
+  switch(arg_type) {
+  case ARG_NO:
+  case ARG_FLAG:
+    break;
+  default:
+    if (value && orig_field) {
+      if (no_free) {
+        *orig_field = value;
+      } else {
+        if (*orig_field)
+          free (*orig_field); /* free previous string */
+        *orig_field = gengetopt_strdup (value);
+      }
+    }
+  };
+
+  return 0; /* OK */
+}
+
+
+int
+RNAinverse_cmdline_parser_internal (
+  int argc, char **argv, struct RNAinverse_args_info *args_info,
+                        struct RNAinverse_cmdline_parser_params *params, const char *additional_error)
+{
+  int c;       /* Character of the parsed option.  */
+
+  int error = 0;
+  struct RNAinverse_args_info local_args_info;
+  
+  int override;
+  int initialize;
+  int check_required;
+  int check_ambiguity;
+
+  char *optarg;
+  int optind;
+  int opterr;
+  int optopt;
+  
+  package_name = argv[0];
+  
+  override = params->override;
+  initialize = params->initialize;
+  check_required = params->check_required;
+  check_ambiguity = params->check_ambiguity;
+
+  if (initialize)
+    RNAinverse_cmdline_parser_init (args_info);
+
+  RNAinverse_cmdline_parser_init (&local_args_info);
+
+  optarg = 0;
+  optind = 0;
+  opterr = params->print_errors;
+  optopt = '?';
+
+  while (1)
+    {
+      int option_index = 0;
+
+      static struct option long_options[] = {
+        { "help",      0, NULL, 'h' },
+        { "detailed-help",     0, NULL, 0 },
+        { "full-help", 0, NULL, 0 },
+        { "version",   0, NULL, 'V' },
+        { "repeat",    2, NULL, 'R' },
+        { "alphabet",  1, NULL, 'a' },
+        { "verbose",   0, NULL, 'v' },
+        { "function",  1, NULL, 'F' },
+        { "final",     1, NULL, 'f' },
+        { "temp",      1, NULL, 'T' },
+        { "noTetra",   0, NULL, '4' },
+        { "dangles",   1, NULL, 'd' },
+        { "noGU",      0, NULL, 0 },
+        { "noClosingGU",       0, NULL, 0 },
+        { "paramFile", 1, NULL, 'P' },
+        { "nsp",       1, NULL, 0 },
+        { "energyModel",       1, NULL, 'e' },
+        { 0,  0, 0, 0 }
+      };
+
+      custom_optarg = optarg;
+      custom_optind = optind;
+      custom_opterr = opterr;
+      custom_optopt = optopt;
+
+      c = custom_getopt_long (argc, argv, "hVR::a:vF:f:T:4d:P:e:", long_options, &option_index);
+
+      optarg = custom_optarg;
+      optind = custom_optind;
+      opterr = custom_opterr;
+      optopt = custom_optopt;
+
+      if (c == -1) break;      /* Exit from `while (1)' loop.  */
+
+      switch (c)
+        {
+        case 'h':      /* Print help and exit.  */
+          RNAinverse_cmdline_parser_print_help ();
+          RNAinverse_cmdline_parser_free (&local_args_info);
+          exit (EXIT_SUCCESS);
+
+        case 'V':      /* Print version and exit.  */
+          RNAinverse_cmdline_parser_print_version ();
+          RNAinverse_cmdline_parser_free (&local_args_info);
+          exit (EXIT_SUCCESS);
+
+        case 'R':      /* Search repeatedly for the same structure.
+        If an argument is supplied to this option it must follow the option flag immediately. E.g.: -R5
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->repeat_arg), 
+               &(args_info->repeat_orig), &(args_info->repeat_given),
+              &(local_args_info.repeat_given), optarg, 0, "100", ARG_INT,
+              check_ambiguity, override, 0, 0,
+              "repeat", 'R',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'a':      /* Find sequences using only nucleotides from a given alphabet.
+        
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->alphabet_arg), 
+               &(args_info->alphabet_orig), &(args_info->alphabet_given),
+              &(local_args_info.alphabet_given), optarg, 0, 0, ARG_STRING,
+              check_ambiguity, override, 0, 0,
+              "alphabet", 'a',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'v':      /* In conjunction with a negative value supplied to -R, print the last subsequence and substructure for each unsuccessful search.
+        
+.  */
+        
+        
+          if (update_arg((void *)&(args_info->verbose_flag), 0, &(args_info->verbose_given),
+              &(local_args_info.verbose_given), optarg, 0, 0, ARG_FLAG,
+              check_ambiguity, override, 1, 0, "verbose", 'v',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'F':      /* Use minimum energy (-Fm), partition function folding (-Fp) or both (-Fmp).
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->function_arg), 
+               &(args_info->function_orig), &(args_info->function_given),
+              &(local_args_info.function_given), optarg, 0, "m", ARG_STRING,
+              check_ambiguity, override, 0, 0,
+              "function", 'F',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'f':      /* In combination with -Fp stop search when sequence is found with E(s)-F is smaller than final, where F=-kT*ln(Q).
+        
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->final_arg), 
+               &(args_info->final_orig), &(args_info->final_given),
+              &(local_args_info.final_given), optarg, 0, 0, ARG_FLOAT,
+              check_ambiguity, override, 0, 0,
+              "final", 'f',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'T':      /* Rescale energy parameters to a temperature of temp C. Default is 37C.
+        
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->temp_arg), 
+               &(args_info->temp_orig), &(args_info->temp_given),
+              &(local_args_info.temp_given), optarg, 0, 0, ARG_DOUBLE,
+              check_ambiguity, override, 0, 0,
+              "temp", 'T',
+              additional_error))
+            goto failure;
+        
+          break;
+        case '4':      /* Do not include special tabulated stabilizing energies for tri-, tetra- and hexaloop hairpins. Mostly for testing.
+        
+.  */
+        
+        
+          if (update_arg((void *)&(args_info->noTetra_flag), 0, &(args_info->noTetra_given),
+              &(local_args_info.noTetra_given), optarg, 0, 0, ARG_FLAG,
+              check_ambiguity, override, 1, 0, "noTetra", '4',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'd':      /* How to treat \"dangling end\" energies for bases adjacent to helices in free ends and multi-loops
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->dangles_arg), 
+               &(args_info->dangles_orig), &(args_info->dangles_given),
+              &(local_args_info.dangles_given), optarg, 0, "2", ARG_INT,
+              check_ambiguity, override, 0, 0,
+              "dangles", 'd',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'P':      /* Read energy parameters from paramfile, instead of using the default parameter set.
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->paramFile_arg), 
+               &(args_info->paramFile_orig), &(args_info->paramFile_given),
+              &(local_args_info.paramFile_given), optarg, 0, 0, ARG_STRING,
+              check_ambiguity, override, 0, 0,
+              "paramFile", 'P',
+              additional_error))
+            goto failure;
+        
+          break;
+        case 'e':      /* Rarely used option to fold sequences from the artificial ABCD... alphabet, where A pairs B, C-D etc.  Use the energy parameters for GC (-e 1) or AU (-e 2) pairs.
+        
+.  */
+        
+        
+          if (update_arg( (void *)&(args_info->energyModel_arg), 
+               &(args_info->energyModel_orig), &(args_info->energyModel_given),
+              &(local_args_info.energyModel_given), optarg, 0, 0, ARG_INT,
+              check_ambiguity, override, 0, 0,
+              "energyModel", 'e',
+              additional_error))
+            goto failure;
+        
+          break;
+
+        case 0:        /* Long option with no short option */
+          if (strcmp (long_options[option_index].name, "detailed-help") == 0) {
+            RNAinverse_cmdline_parser_print_detailed_help ();
+            RNAinverse_cmdline_parser_free (&local_args_info);
+            exit (EXIT_SUCCESS);
+          }
+
+          if (strcmp (long_options[option_index].name, "full-help") == 0) {
+            RNAinverse_cmdline_parser_print_full_help ();
+            RNAinverse_cmdline_parser_free (&local_args_info);
+            exit (EXIT_SUCCESS);
+          }
+
+          /* Do not allow GU pairs
+          
+.  */
+          if (strcmp (long_options[option_index].name, "noGU") == 0)
+          {
+          
+          
+            if (update_arg((void *)&(args_info->noGU_flag), 0, &(args_info->noGU_given),
+                &(local_args_info.noGU_given), optarg, 0, 0, ARG_FLAG,
+                check_ambiguity, override, 1, 0, "noGU", '-',
+                additional_error))
+              goto failure;
+          
+          }
+          /* Do not allow GU pairs at the end of helices
+          
+.  */
+          else if (strcmp (long_options[option_index].name, "noClosingGU") == 0)
+          {
+          
+          
+            if (update_arg((void *)&(args_info->noClosingGU_flag), 0, &(args_info->noClosingGU_given),
+                &(local_args_info.noClosingGU_given), optarg, 0, 0, ARG_FLAG,
+                check_ambiguity, override, 1, 0, "noClosingGU", '-',
+                additional_error))
+              goto failure;
+          
+          }
+          /* Allow other pairs in addition to the usual AU,GC,and GU pairs.
+.  */
+          else if (strcmp (long_options[option_index].name, "nsp") == 0)
+          {
+          
+          
+            if (update_arg( (void *)&(args_info->nsp_arg), 
+                 &(args_info->nsp_orig), &(args_info->nsp_given),
+                &(local_args_info.nsp_given), optarg, 0, 0, ARG_STRING,
+                check_ambiguity, override, 0, 0,
+                "nsp", '-',
+                additional_error))
+              goto failure;
+          
+          }
+          
+          break;
+        case '?':      /* Invalid option.  */
+          /* `getopt_long' already printed an error message.  */
+          goto failure;
+
+        default:       /* bug: option not considered.  */
+          fprintf (stderr, "%s: option unknown: %c%s\n", RNAINVERSE_CMDLINE_PARSER_PACKAGE, c, (additional_error ? additional_error : ""));
+          abort ();
+        } /* switch */
+    } /* while */
+
+
+
+
+  RNAinverse_cmdline_parser_release (&local_args_info);
+
+  if ( error )
+    return (EXIT_FAILURE);
+
+  return 0;
+
+failure:
+  
+  RNAinverse_cmdline_parser_release (&local_args_info);
+  return (EXIT_FAILURE);
+}