Next version of JABA
[jabaws.git] / binaries / src / mafft / core / treeOperation.c
1 #include "mltaln.h"
2
3 #define DEBUG 0
4
5 #define EF_THREEWAY 1.0
6 #define MAXBW 1.0
7 #define MINBW 0.01
8
9 #define MINLEN 0.001
10
11 #if DEBUG
12 Node *stopol_g;
13 #endif
14
15
16 void checkMinusLength( int nseq, double **len )
17 {
18         int i, j;
19         for( i=0; i<nseq-1; i++ ) for( j=0; j<2; j++ ) 
20                 if( len[i][j] < MINLEN ) len[i][j] = MINLEN;
21 }
22
23 void negativeMember2( int *mem, int *query, int locnseq )
24 {
25         int *ptr;
26         char *tmp;
27         int i;
28         int n;
29
30         tmp = AllocateCharVec( locnseq );
31
32         for( i=0; i<locnseq; i++ ) tmp[i] = 0;
33         while( (n=*query++) != -1 ) tmp[n] = 1;
34
35         ptr = mem;
36         for( i=0; i<locnseq; i++ ) 
37         {
38                 if( !tmp[i] ) 
39                 {
40                         *ptr++ = i;
41                 }
42         }
43         *ptr = -1;
44         free( tmp );
45 }
46
47 int *negativeMember( int *query, int locnseq )
48 {
49         int *bk, *value = NULL;
50         char *tmp;
51         int i;
52         int n;
53
54         tmp = AllocateCharVec( locnseq );
55         bk = value = AllocateIntVec( locnseq );
56         if( !value ) ErrorExit( "Cannot allocate value" );
57
58         for( i=0; i<locnseq; i++ ) tmp[i] = 0;
59         while( (n=*query++) != -1 ) tmp[n] = 1;
60
61         for( i=0; i<locnseq; i++ ) 
62         {
63                 if( !tmp[i] )
64                 {
65                         fprintf( stderr, "%3d ", i );
66                         *value++ = i;
67                 }
68         }
69         fprintf( stderr, "\n" );
70         *value = -1;
71         free( tmp );
72         return( bk );
73 }
74
75 int IntExistsInVec( int query, int *vector )
76 {
77         while( *vector != -1 )
78                 if( query == *vector++ ) return( 1 );
79         return( 0 );
80 }
81
82 NodeInCub searchParent( int top, int ***topol, int Start, int End )
83 {
84         int i, j;
85         NodeInCub value;
86         for( i=Start; i<End; i++ ) 
87         {
88                 for( j=0; j<2; j++ ) 
89                 {
90                         if( IntExistsInVec( top, topol[i][j] ) )
91                         {
92                                 value.step = i; 
93                                 value.LorR = j; 
94                                 return( value );
95                         }
96                 }
97         }
98         fprintf( stderr, "ERROR!!!\n" );
99         ErrorExit( "Error in searchParent" );
100         value.step=0; // by D.Mathog, katoh
101         value.LorR=0; // by D.Mathog, katoh
102         return( value );
103 }
104
105 void stopolInit( int n, Node *stopol )
106 {
107         int i, j;
108         for( i=0; i<n; i++ )
109         {
110                 for( j=0; j<3; j++ ) 
111                 {       
112                         stopol[i].length[j] = 0.0;
113                         stopol[i].children[j] = NULL;
114                         stopol[i].tmpChildren[j] = -1;
115                         stopol[i].top[j] = -1;
116                         stopol[i].members[j] = NULL;
117                         stopol[i].weightptr[j] = NULL;
118                 }
119         }
120 #if 0
121         while( --numintvec >= 0 )
122         {
123                 free( tmpintvec[numintvec] );
124         }
125         free( tmpintvec );
126         numintvec = 0;
127 #endif
128 }
129
130 void treeCnv( Node *stopol, int locnseq, int ***topol, double **len, double **bw )
131 {
132         int i;
133         NodeInCub parent;
134         int *count;
135         int ccount;
136         int rep;
137         int tmpint;
138         static int **tmpintvec = NULL;
139         static int numintvec = 0;
140
141         count = AllocateIntVec(  2 * locnseq ); /* oome */
142         if( !count ) ErrorExit( "Cannot allocate count.\n" );
143
144         checkMinusLength( locnseq, len ); /* uwagaki */
145
146         stopolInit( locnseq * 2, stopol );
147         for( i=0; i<locnseq * 2; i++ ) count[i] = 0;
148
149         for( i=locnseq; i<locnseq*2; i++ ) 
150         {
151                 rep = i - locnseq;
152                 parent = searchParent( rep, topol, 0, locnseq-1 ); 
153 #if DEBUG
154                 fprintf( stderr, "Parent of node No.%d ( Seq No.%d )  = %d - %d\n", i, i-locnseq, parent.step, parent.LorR );
155 #endif
156
157                 ccount = count[parent.step];
158                 stopol[parent.step].length[ccount] = len[parent.step][parent.LorR];
159                 stopol[parent.step].weightptr[ccount] = &(bw[parent.step][parent.LorR]);
160                 stopol[parent.step].children[ccount] = &stopol[i];
161                 stopol[parent.step].tmpChildren[ccount] = i;
162                 stopol[parent.step].members[ccount] = topol[parent.step][parent.LorR];
163                 count[parent.step]++;
164
165                 ccount = count[i];
166                 stopol[i].length[ccount] = len[parent.step][parent.LorR];
167                 stopol[i].weightptr[ccount] = &(bw[parent.step][parent.LorR]);
168                 stopol[i].children[ccount] = &stopol[parent.step];
169                 stopol[i].tmpChildren[ccount] = parent.step;
170                 stopol[i].members[ccount] = topol[parent.step][parent.LorR];
171                 count[i]++;
172         }
173         for( i=0; i<locnseq-2; i++ ) 
174         {
175                 rep = MIN( topol[i][0][0], topol[i][1][0] );
176                 parent = searchParent( rep, topol, i+1, locnseq-1 ); 
177                 ccount = count[parent.step];
178                 stopol[parent.step].length[ccount] = len[parent.step][parent.LorR];
179                 stopol[parent.step].weightptr[ccount] = &(bw[parent.step][parent.LorR]);
180                 stopol[parent.step].children[ccount] = &stopol[i];
181                 stopol[parent.step].tmpChildren[ccount] = i;
182                 stopol[parent.step].members[ccount] = topol[parent.step][parent.LorR];
183                 count[parent.step]++;
184
185                 ccount = count[i];
186                 stopol[i].length[ccount] = len[parent.step][parent.LorR];
187                 stopol[i].weightptr[ccount] = &(bw[parent.step][parent.LorR]);
188                 stopol[i].children[ccount] = &stopol[parent.step];
189                 stopol[i].tmpChildren[ccount] = parent.step;
190 #if 0
191                 stopol[i].members[ccount] = negativeMember( topol[parent.step][parent.LorR], locnseq );
192 #else
193 //              fprintf( stderr, "allocating numintvec = %d\n",  numintvec );
194                 tmpintvec = (int **)realloc( (void *)tmpintvec, (numintvec+1) * sizeof( int * ) );
195                 tmpintvec[numintvec] = (int *)calloc( locnseq, sizeof( int ) );
196                 negativeMember2( tmpintvec[numintvec], topol[parent.step][parent.LorR], locnseq );
197                 stopol[i].members[ccount] = tmpintvec[numintvec];
198                 numintvec++;
199 #endif
200                 count[i]++;
201 #if DEBUG
202                 fprintf( stderr, "Parent of node No.%d = %d - %d\n", i, parent.step, parent.LorR );
203 #endif
204         }
205 /*
206                         Unrooted tree.
207                         locnseq-2 no children no nakade, 
208                         locnseq-3 wo sashiteinai mono wo sagashite,
209                         locnseq-3 no children ni kuwae,
210                         locnseq-2 wo sashiteita node no chilren wo
211                         locnseq-3 ni kaeru.
212 */
213 #if DEBUG
214         fprintf( stderr, "BEFORE MODIFY\n" );
215         for( i=0; i<locnseq*2; i++ )  
216         {
217                 for( j=0; j<3; j++ ) 
218                 {
219                         fprintf( stderr, "stopol[%d].tmpChildren[%d] = %d, children[%d] = %d \n", i, j, stopol[i].tmpChildren[j], j, stopol[i].children[j] - stopol );
220                 }
221         }
222 #endif
223
224         if     ( stopol[locnseq-2].children[0] == &stopol[locnseq-3] ) i = 1;
225         else if( stopol[locnseq-2].children[1] == &stopol[locnseq-3] ) i = 0;
226         else ErrorExit( "?\n" );
227
228         stopol[locnseq-3].length[2] = len[locnseq-2][0] + len[locnseq-2][1];
229         stopol[locnseq-3].weightptr[2] = &bw[locnseq-2][0];
230         stopol[locnseq-3].children[2] = stopol[locnseq-2].children[i];
231         stopol[locnseq-3].tmpChildren[2] = stopol[locnseq-2].tmpChildren[i];
232
233         tmpint = (int)( stopol[locnseq-2].children[i] - stopol );
234
235         stopol[tmpint].children[2] = &stopol[locnseq-3];
236         stopol[tmpint].length[2] = len[locnseq-2][0] + len[locnseq-2][1];
237         stopol[tmpint].weightptr[2] = &bw[locnseq-2][0];
238         stopol[tmpint].tmpChildren[2] = locnseq-3;
239
240
241 #if DEBUG
242         for( i=0; i<locnseq*2; i++ )  
243         {
244                 for( j=0; j<3; j++ ) 
245                 {
246                         fprintf( stderr, "stopol[%d].tmpChildren[%d] = %d, children[%d] = %d \n", i, j, stopol[i].tmpChildren[j], j, stopol[i].children[j] - stopol );
247                 }
248         }
249
250         for( i=0; i<locnseq*2; i++ )  
251         {
252                 fprintf( stderr, "-- stopol[%d]\n", i );
253                 for( j=0; j<3; j++ ) 
254                 {
255                         if( !stopol[i].members[j] ) 
256                         {
257                                 fprintf( stderr, "LEAF\n" );
258                                 break;
259                         }
260                         fprintf( stderr, "      group %d are \n", j );
261                         for( k=0; (n=stopol[i].members[j][k]) != -1; k++ ) 
262                         {       
263                                 fprintf( stderr, "%#5d", n );
264                         }
265                         fprintf( stderr, "\n" );
266                 }
267                 fprintf( stderr, "\n" );
268         }
269 #endif
270
271 #if DEBUG
272         stopol_g = stopol;
273 #endif
274         free( count );
275 }
276
277 int isLeaf( Node node )
278 {
279         if( node.children[1] ) return( 0 );
280         else                   return( 1 );
281 }
282
283 double syntheticLength( Node *ob, Node *oppositeNode )
284 {
285         int i, count;
286         int dir_ch[3];
287         int dir_pa = -10; // by katoh
288         double value, tmpvalue0, tmpvalue1;
289         int nanflag = 0;
290
291 #if DEBUG
292         fprintf( stderr, "In syntheticLength\n" );
293         fprintf( stderr, "ob - stopol_g = %d\n", ob - stopol_g );
294         fprintf( stderr, "op - stopol_g = %d\n", oppositeNode - stopol_g );
295 #endif
296
297         if( isLeaf( *ob ) ) 
298         {
299 #if DEBUG
300                 fprintf( stderr, "LEAF\n\n" );
301 #endif
302                 return( ob->length[0] );
303         }
304
305         for( i=0, count=0; i<3; i++ ) 
306         {
307 #if DEBUG
308                 fprintf( stderr, "ob->tmpChildren[%d] = %d\n", i, ob->tmpChildren[i] );
309 #endif
310                 if( oppositeNode != ob->children[i] ) dir_ch[count++] = i;
311                 else dir_pa = i;
312         }
313 #if DEBUG
314                 fprintf( stderr, "\n" );
315 #endif
316         if( count != 2 ) 
317         {
318 #if DEBUG
319                 fprintf( stderr, "Node No.%d has no child like No.%d \n", ob-stopol_g, oppositeNode-stopol_g );
320 #endif
321                 ErrorExit( "Invalid call\n" );
322         }
323
324         tmpvalue0 = syntheticLength( ob->children[dir_ch[0]], ob ); 
325         tmpvalue1 = syntheticLength( ob->children[dir_ch[1]], ob ); 
326
327 #if DEBUG
328         fprintf( stderr, "tmpvalue0 = %f\n", tmpvalue0 );
329         fprintf( stderr, "tmpvalue1 = %f\n", tmpvalue1 );
330 #endif  
331         if( tmpvalue0 ) tmpvalue0 = 1.0 / tmpvalue0;
332         else nanflag = 1;
333         if( tmpvalue1 ) tmpvalue1 = 1.0 / tmpvalue1;
334         else nanflag = 1;
335
336         if( nanflag ) value = 0.0;
337         else
338         {
339                 value = tmpvalue0 + tmpvalue1;
340                 value = 1.0 / value;
341         }
342         value += ob->length[dir_pa];
343 #if DEBUG
344         fprintf( stderr, "value = %f\n", value  );
345 #endif
346
347         return( value );
348 }
349
350 double calcW( Node *ob, Node *op )
351 {
352         int i, count;
353         int dir_ch[3];
354         int dir_pa = -10; // by katoh
355         double a, b, c, f, s;
356         double value;
357
358         if( isLeaf( *ob ) ) 
359                 return( 1.0 );
360
361         for( i=0, count=0; i<3; i++ ) 
362         {
363                 if( op != ob->children[i] ) dir_ch[count++] = i;
364                 else dir_pa = i;
365         }
366         if( count != 2 ) ErrorExit( "Invalid call of calcW\n" );
367
368 #if DEBUG
369         fprintf( stderr, "In calcW\n" );
370         fprintf( stderr, "ob = %d\n", ob - stopol_g );
371         fprintf( stderr, "op = %d\n", op - stopol_g );
372         fprintf( stderr, "ob->children[c1] = %d\n", ob->children[dir_ch[0]] - stopol_g );
373         fprintf( stderr, "ob->children[c2] = %d\n", ob->children[dir_ch[1]] - stopol_g );
374         fprintf( stderr, "ob->children[pa] = %d\n", ob->children[dir_pa] - stopol_g );
375         fprintf( stderr, "\n" );
376 #endif
377
378         a = syntheticLength( ob->children[dir_ch[0]], ob );
379         b = syntheticLength( ob->children[dir_ch[1]], ob );
380         c = syntheticLength( ob->children[dir_pa], ob );
381
382 #if DEBUG
383         fprintf( stderr, "a = %f\n", a );
384         fprintf( stderr, "b = %f\n", b );
385         fprintf( stderr, "c = %f\n", c );
386 #endif
387
388         if( !c ) return( MAXBW );
389         if ( !a || !b ) return( MINBW );  /* ? */
390
391         f = EF_THREEWAY;
392         s = ( b*c + c*a + a*b );
393
394         value = a*b*(c+a)*(c+b) / ( c*(a+b) * f * s );
395
396         value = sqrt( value );
397
398         return( value );
399 }
400
401 void calcBranchWeight( double **bw, int locnseq, Node *stopol, int ***topol, double **len )
402 {
403         NodeInCub parent;
404         int i;
405         int rep;
406         Node *topNode, *btmNode;
407         double topW, btmW;
408
409         for( i=locnseq; i<locnseq*2; i++ )
410         {
411                 rep = i - locnseq;
412                 parent = searchParent( rep, topol, 0, locnseq-1 );
413                 if( parent.step == locnseq - 2 ) continue;
414
415                 topNode = stopol+parent.step; btmNode = stopol+i;
416 #if DEBUG
417                 fprintf( stderr, "In calcBranchWeight, topNode=%d, btmNode=%d\n", topNode-stopol_g, btmNode-stopol_g );
418 #endif
419                 topW = calcW( topNode, btmNode );
420                 btmW = calcW( btmNode, topNode );
421                 bw[parent.step][parent.LorR] = topW * btmW;
422         }
423         for( i=0; i<locnseq-3; i++ ) 
424         {
425                 rep = MIN( topol[i][0][0], topol[i][1][0] );
426                 parent = searchParent( rep, topol, i+1, locnseq-1 ); 
427                 if( parent.step == locnseq - 2 ) continue;
428                 topNode = stopol+parent.step;
429                 btmNode = stopol+i;
430 #if DEBUG
431                 fprintf( stderr, "In calcBranchWeight, topNode=%d, btmNode=%d\n", topNode-stopol_g, btmNode-stopol_g );
432 #endif
433                 topW = calcW( topNode, btmNode );
434                 btmW = calcW( btmNode, topNode );
435                 bw[parent.step][parent.LorR] = topW * btmW;
436         }
437
438         topNode = stopol[locnseq-3].children[2];
439         btmNode = stopol + i;
440         topW = calcW( topNode, btmNode );
441         btmW = calcW( btmNode, topNode );
442         bw[locnseq-2][0] = topW * btmW;
443         bw[locnseq-2][1] = 1.0;
444 }
445
446 void branchWeightToPairWeight( int locnseq, int ***topol, double **pw, double **bw )
447 {
448         int i, j, k, n0, n1;
449 #if 0
450         double wFromLeaf[locnseq];
451 #else
452         static double *wFromLeaf = NULL;
453         if( wFromLeaf == NULL )
454                 wFromLeaf = AllocateDoubleVec( locnseq );
455 #endif
456
457 #if DEBUG
458         for( i=0; i<locnseq-1; i++ ) for( j=0; j<2; j++ ) 
459                 fprintf( stderr, "pw[%d][%d] = %f\n", i, j, bw[i][j] );
460 #endif
461
462         for( i=0; i<locnseq; i++ ) wFromLeaf[i] = 1.0;
463         for( i=0; i<locnseq; i++ ) for( j=0; j<locnseq; j++ ) 
464                 pw[i][j] = 0.0;
465         for( i=0; i<locnseq-1; i++ ) 
466         {
467                 for( j=0; (n0=topol[i][0][j])!=-1; j++ ) 
468                         for( k=0; (n1=topol[i][1][k])!=-1; k++ ) 
469                                 pw[MIN( n0, n1 )][MAX( n0, n1 )] 
470                                 = wFromLeaf[n0] * wFromLeaf[n1] * bw[i][0] * bw[i][1];
471                 for( j=0; (n0=topol[i][0][j])!=-1; j++ ) 
472                         wFromLeaf[n0] *= bw[i][0];
473                 for( j=0; (n1=topol[i][1][j])!=-1; j++ ) 
474                         wFromLeaf[n1] *= bw[i][1];
475         }
476 }
477
478 void weightFromABranch_rec( double *result, Node *ob, Node *op )
479 {
480         int i, n, count;
481         int dir_ch[3], dir_pa;
482
483 #if DEBUG
484         fprintf( stderr, "In weightFromABranch_rec, ob = %d\n", ob - stopol_g );
485 #endif
486         if( isLeaf( *ob ) ) return;
487         for( i=0, count=0; i<3; i++ ) 
488         {
489                 if( ob->children[i] != op ) dir_ch[count++] = i;
490                 else dir_pa = i;
491         }
492         if( count != 2 ) 
493         {
494 #if DEBUG
495                 fprintf( stderr, "Node No.%d has no child like No.%d \n", ob-stopol_g, op-stopol_g );
496 #endif
497                 ErrorExit( "Incorrect call of weightFromABranch_rec" );
498         }
499         for( i=0; (n=ob->members[dir_ch[0]][i])!=-1; i++ ) 
500                 result[n] *= *ob->weightptr[dir_ch[0]];
501         weightFromABranch_rec( result, ob->children[dir_ch[0]], ob );
502
503         for( i=0; (n=ob->members[dir_ch[1]][i])!=-1; i++ ) 
504                 result[n] *= *ob->weightptr[dir_ch[1]];
505         weightFromABranch_rec( result, ob->children[dir_ch[1]], ob );
506 }
507
508 void weightFromABranch( int nseq, double *result, Node *stopol, int ***topol, int step, int LorR )
509 {
510         Node *topNode, *btmNode;
511         int i;
512
513         if( step == nseq - 2 )
514         {
515                 topNode = stopol[nseq-2].children[0];
516                 btmNode = stopol + nseq-3;
517 #if DEBUG
518                 fprintf( stderr, "Now step == nseq-3, topNode = %d, btmNode = %d\n", topNode - stopol_g, btmNode-stopol_g );
519 #endif
520         }
521                 
522         else
523         {
524                 for( i=0; i<3; i++ ) 
525                 {
526                         if( stopol[step].members[i][0] == topol[step][LorR][0] )
527                         break;
528                 }
529                 if( i== 3 ) ErrorExit( "Incorrect call of weightFromABranch." );
530                 btmNode = stopol[step].children[i];
531                 topNode = stopol+step;
532         }
533
534         for( i=0; i<nseq; i++ ) result[i] = 1.0;
535         weightFromABranch_rec( result, btmNode, topNode ); 
536         weightFromABranch_rec( result, topNode, btmNode ); 
537 #if 0
538         for( i=0; i<nseq; i++ )
539                 fprintf( stdout, "w[%d] = %f\n", i, result[i] );
540 #endif
541 //      fprintf( stderr, "new weight!\n" );
542 //      for( i=0; i<nseq; i++ )
543 //              result[i] *= result[i];
544
545
546 }
547 void assignstrweight_rec( double *strweight, Node *ob, Node *op, char *kozoari, double *seqweight )
548 {
549         int i, n, count, lastkozo;
550         int dir_ch[3], dir_pa;
551         double sumweight;
552
553 #if DEBUG
554         fprintf( stderr, "In weightFromABranch_rec, ob = %d\n", ob - stopol_g );
555 #endif
556         if( isLeaf( *ob ) )
557         {
558 //              fprintf( stderr, "Leaf!\n" );
559                 return;
560         }
561         for( i=0, count=0; i<3; i++ ) 
562         {
563                 if( ob->children[i] != op ) dir_ch[count++] = i;
564                 else dir_pa = i;
565         }
566         if( count != 2 ) 
567         {
568 #if DEBUG
569                 fprintf( stderr, "Node No.%d has no child like No.%d \n", ob-stopol_g, op-stopol_g );
570 #endif
571                 ErrorExit( "Incorrect call of weightFromABranch_rec" );
572         }
573
574
575 //      fprintf( stderr, "\n" );
576         sumweight = 0.0;
577         count = 0;
578         lastkozo = -1;
579         for( i=0; (n=ob->members[dir_ch[0]][i])!=-1; i++ ) 
580         {
581 //              fprintf( stderr, "member1! n=%d\n", n );
582                 sumweight += seqweight[n];
583                 if( kozoari[n] ) 
584                 {
585                         count++;
586                         lastkozo = n;
587                 }
588         }
589         for( i=0; (n=ob->members[dir_ch[1]][i])!=-1; i++ ) 
590         {
591 //              fprintf( stderr, "member2! n=%d\n", n );
592                 sumweight += seqweight[n];
593                 if( kozoari[n] ) 
594                 {
595                         count++;
596                         lastkozo = n;
597                 }
598         }
599
600 //      fprintf( stderr, "count = %d\n", count );
601
602         if( count == 1 )
603                 strweight[lastkozo] = sumweight;
604         else if( count > 1 )
605         {
606                 assignstrweight_rec( strweight, ob->children[dir_ch[0]], ob, kozoari, seqweight );
607                 assignstrweight_rec( strweight, ob->children[dir_ch[1]], ob, kozoari, seqweight );
608         }
609 }
610
611 void assignstrweight( int nseq, double *strweight, Node *stopol, int ***topol, int step, int LorR, char *kozoari, double *seqweight )
612 {
613         Node *topNode, *btmNode;
614         int i;
615
616         if( step == nseq - 2 )
617         {
618                 topNode = stopol[nseq-2].children[0];
619                 btmNode = stopol + nseq-3;
620 #if DEBUG
621                 fprintf( stderr, "Now step == nseq-3, topNode = %d, btmNode = %d\n", topNode - stopol_g, btmNode-stopol_g );
622 #endif
623         }
624                 
625         else
626         {
627                 for( i=0; i<3; i++ ) 
628                 {
629                         if( stopol[step].members[i][0] == topol[step][LorR][0] )
630                         break;
631                 }
632                 if( i== 3 ) ErrorExit( "Incorrect call of weightFromABranch." );
633                 btmNode = stopol[step].children[i];
634                 topNode = stopol+step;
635         }
636
637         for( i=0; i<nseq; i++ ) strweight[i] = 0.0;
638         for( i=0; i<nseq; i++ ) if( kozoari[i] ) strweight[i] = seqweight[i];
639 //      fprintf( stderr, "calling _rec (1)\n" );
640         assignstrweight_rec( strweight, btmNode, topNode, kozoari, seqweight ); 
641 //      fprintf( stderr, "calling _rec (2)\n" );
642         assignstrweight_rec( strweight, topNode, btmNode, kozoari, seqweight ); 
643
644 #if 1 // nazeka kokowo tobasuto seido ga sagaru ?????
645         fprintf( stderr, "STEP %d\n", step );
646         for( i=0; topol[step][0][i]>-1; i++ )
647                 fprintf( stderr, "%3d ", topol[step][0][i] );
648         fprintf( stderr, "\n" );
649         for( i=0; topol[step][1][i]>-1; i++ )
650                 fprintf( stderr, "%3d ", topol[step][1][i] );
651         fprintf( stderr, "\n" );
652         for( i=0; i<nseq; i++ )
653                 fprintf( stderr, "seqweight[%d] = %f\n", i, seqweight[i] );
654         for( i=0; i<nseq; i++ )
655                 fprintf( stderr, "strweight[%d] = %f\n", i, strweight[i] );
656         fprintf( stderr, "\n" );
657 #endif
658 }